Association between <i>FTO</i> gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

Kroll, Caroline; França, Paulo Henrique Condeixa de; Mastroeni, Marco Fábio

doi:10.1002/ajhb.23164

Cited by 5 publications

(5 citation statements)

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“…An in-depth description of the PREDI Study has been published previously (28)(29)(30)(31) . Briefly, all women over 18 years of age who gave birth to a full-term singleton (between 37 and 42 weeks of gestation) admitted to a public maternity hospital in Joinville (Brazil) from 14 January to 16 February 2012 were invited to participate.…”

Section: Study Design and Populationmentioning

confidence: 99%

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll¹,

Farias²,

Kac³

et al. 2020

Br J Nutr

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Excess body weight confers a high risk to human health. Body weight variation between subjects can be partially explained by genetic differences. The aim of this study was to investigate the association of genetic variants in the ADIPOQ (rs2241766) and LEP (rs7799039) genes with body weight trajectories in children from birth to six years of age. This was a prospective cohort (PREDI Study). Socioeconomic, biological and anthropometric data were collected at four time points: at birth in the maternity unit; 1-2 years old, 4-5 years old, and 6 years old at the participant’s home. Genotyping was performed by PCR-RFLP. Poisson regression and linear mixed-effect regression models were used to address the association of ADIPOQ and LEP genotypes with BMI. Excessive body weight at pre-pregnancy (β=0.339, p=0.01) and excessive gestational weight gain (β=0.51, p<0.001) were associated with children’s BMI trajectory from birth to six years. The ADIPOQ-rs2241766 TG or GG genotype was associated with a higher risk of excess body weight in the first six years of life (both sexes: RR=1.25, 95%CI: 1.01-1.56; female: RR=1.67, 95%CI: 1.20-2.31). BMI increased over the years according to the presence of the TG or GG genotype (β=0.01, 95%CI: 0.01-0.02), particularly in females (β=0.02, 95%CI: 0.01-0.04). The ADIPOQ-rs2241766 TG and GG genotypes increased the risk of excess body weight in children from birth to six years of age and had a positive effect on body weight trajectories in girls. The LEP-rs7799039 genetic variant was not associated with body weight trajectory in children.

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Section: Study Design and Populationmentioning

confidence: 99%

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Kroll¹,

Farias²,

Kac³

et al. 2020

Br J Nutr

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“…The A allele for the rs9939609 polymorphism in the FTO gene was previously associated with higher BMI before and after pregnancy [ 38 , 39 ] but not with excessive GWG [ 15 ] in Brazilian women. Studies from the USA [ 12 , 13 ] and Spain [ 14 ] found a higher risk of having higher GWG among A-allele carriers, contradicting the results from Turkey [ 40 ] and Mexico [ 41 ], both without association.…”

Section: Discussionmentioning

confidence: 99%

FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial

et al. 2022

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Excessive gestational weight gain (GWG) is associated with increased risk of maternal and neonatal complications. We investigated obesity-related polymorphisms in the FTO gene (rs9939609, rs17817449) and ADRB2 (rs1042713, rs1042714) as candidate risk factors concerning excessive GWG in pregnant women with pregestational diabetes. This nutrigenetic trial, conducted in Brazil, randomly assigned 70 pregnant women to one of the groups: traditional diet (n = 41) or DASH diet (n = 29). Excessive GWG was the total weight gain above the upper limit of the recommendation, according to the Institute of Medicine guidelines. Genotyping was performed using real-time PCR. Time-to-event analysis was performed to investigate risk factors for progression to excessive GWG. Regardless the type of diet, AT carriers of rs9939609 (FTO) and AA carriers of rs1042713 (ADRB2) had higher risk of earlier exceeding GWG compared to TT (aHR 2.44; CI 95% 1.03–5.78; p = 0.04) and GG (aHR 3.91; CI 95% 1.12–13.70; p = 0.03) genotypes, respectively, as the AG carriers for FTO haplotype rs9939609:rs17817449 compared to TT carriers (aHR 1.79; CI 95% 1.04–3.06; p = 0.02).

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“…In a study on 406 Brazilian adult women, it was reported that there was a higher frequency of excessive GWG in those with the TT genotype (51%) compared to those with other genotypes; however, this finding did not have statistical significance, and Caucasian women did not report any associations. Only this genetic variant was associated with pBMI and the period after delivery [ 27 ] until 2–4 years postpartum. This phenomenon could begin to occur at young ages via the LEPR SNV, which could modify some metabolic indicators [ 50 ].…”

Section: Relevant Sectionsmentioning

confidence: 99%

“…The association between specific genetic variants and excessive GWG has been evaluated in 6974 women. The most recent studies came from the United States of America [17,[21][22][23][24], Brazil [25][26][27][28], Romania [29,30], Turkey [31,32], Ukraine [33,34], Canada [35], Germany [36], China [37], and Poland [38]. These studies were performed on pregnant adult women (aged [22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Relevant Sections 21 What Is the Role Of Genomic Sciences In...mentioning

confidence: 99%

“…The most recent studies came from the United States of America [17,[21][22][23][24], Brazil [25][26][27][28], Romania [29,30], Turkey [31,32], Ukraine [33,34], Canada [35], Germany [36], China [37], and Poland [38]. These studies were performed on pregnant adult women (aged [22][23][24][25][26][27][28][29][30][31][32][33][34][35]. As can be observed, only three countries from America, five from Europe, and one from Asia analyzed the probable association between genetic variants and gestational weight gain.…”

Section: Relevant Sections 21 What Is the Role Of Genomic Sciences In...mentioning

confidence: 99%

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Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

Sámano,

Martínez-Rojano,

Chico-Barba

et al. 2024

IJMS

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Excessive or insufficient gestational weight gain (GWG) leads to diverse adverse maternal and neonatal outcomes. There is evidence that pregestational body mass index (pBMI) plays a role in GWG, but no genetic cause has been identified. In this review, we aim to analyze genotype variants associated with GWG. Results: We identified seven genotype variants that may be involved in GWG regulation that were analyzed in studies carried out in Brazil, Romania, the USA, Turkey, Ukraine, and Canada. Some genetic variants were only associated with GWG in certain races or depending on the pBMI. In women who were obese or overweight before gestation, some genetic variants were associated with GWG. Environmental and genetic factors together showed a greater association with GWG than genetic factors alone; for example, type of diet was observed to have a significant influence. Conclusions: We found little scientific evidence of an association between genotype variants in countries with a high prevalence of women of reproductive age who are overweight and obese, such as in Latin America. GWG may be more dependent on environmental factors than genetic variants. We suggest a deeper study of genetic variants, cytokines, and their possible association with GWG, always with the respective control of potential cofounding factors, such as pBMI, diet, and race.

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Association between FTO gene polymorphism and excess body weight in women from before to after pregnancy: A cohort study

Abstract: The FTO-rs9939609 polymorphism was associated with increased weight and BMI in mothers before and after pregnancy. However, we found no significant effect of the polymorphism on excess body weight of women during the reproductive trajectory.

Cited by 5 publications

References 58 publications

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

Adiponectin and leptin gene variants and their effects on body weight trajectories in children from birth to 6 years of age: the PREDI Study

FTO and ADRB2 Genetic Polymorphisms Are Risk Factors for Earlier Excessive Gestational Weight Gain in Pregnant Women with Pregestational Diabetes Mellitus: Results of a Randomized Nutrigenetic Trial

Gestational Weight Gain: Is the Role of Genetic Variants a Determinant? A Review

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