Association Between
            <i>IL-27</i>
            Gene Polymorphisms and Risk of Papillary Thyroid Carcinoma

Nie, Xinwen; Yuan, Fang; Chen, Peng; Pu, Yan; Zhu, Jingqiang; Wang, Yichao; Xiao, Xue; Che, Guanglu; Gao, Linbo; Zhang, Lin

doi:10.2217/bmm-2016-0283

Cited by 14 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies examined the association between DOI:10.31557/APJCP.2020.21.9.2507 IL-27 polymorphisms and the risk of various cancer (Wei et al, 2009;Zhao et al, 2009;Guo et al, 2012;Huang et al, 2012;Pan et al, 2012;Tao et al, 2012;Peng et al, 2013;Munretnam et al, 2014;Tang et al, 2014;Zhang et al, 2014a;Zhang et al, 2014b;Lyu et al, 2015;Pu et al, 2015;Zhang et al, 2015;Zhou et al, 2015;Ge and Xiao, 2016;Wang et al, 2016;Yu et al, 2016;Nie et al, 2017;Ghavami et al, 2018). The findings were controversial, though it is difficult to clarify the inconsistent findings.…”

Section: Discussionmentioning

confidence: 99%

“…It is well-known that IL-27 possesses antitumor activities against a variety of tumor types (Nagai et al, 2010;Di Carlo et al, 2014;Yoshida and Hunter, 2015;Yoshimoto et al, 2015). IL-27 is a polymorphic gene and several studies examined the association between IL-27 gene polymorphisms and risk of various cancers including, non-small-cell lung cancer (NSCLC) (Ge and Xiao, 2016), acute lymphoblastic leukemia (ALL) (Ghavami et al, 2018), nasopharyngeal carcinoma (NPC) (Wei et al, 2009;Pan et al, 2012), colorectal cancer (CRC) (Guo et al, 2012;Huang et al, 2012;Lyu et al, 2015), prostate cancer (PCa) (Munretnam et al, 2014), papillary thyroid carcinoma (PTC) (Zhang et al, 2015;Nie et al, 2017), hepatocellular carcinoma (HCC) (Peng et al, 2013), renal cell carcinoma (RCC) (Pu et al, 2015), osteosarcoma (Tang et al, 2014), esophageal cancer (Tao et al, 2012), cervical cancer (Wang et al, 2016), endometrial cancer (Yu et al, 2016), ovarian cancer (Zhang et al, 2014b), breast cancer (Zhang et al, 2014a), glioma (Zhao et al, 2009), and bladder cancer (Zhou et al, 2015). However, the findings of these studies have been controversial.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Moazeni‐Roodi

Hashemi

Ghavami

2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: Interleukin 27 (IL-27) has potent antitumor activity. Several epidemiological studies have designated that genetic variants of the IL-27 gene may contribute to various cancer susceptibility, but the data were inconclusive. Objective: The current meta-analysis aimed to address the association between IL-27 rs153109, rs17855750, and rs181206 polymorphisms and the risk of cancer. Data Sources: Our team has selected eligible studies up to May 1, 2020, from several electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar databases. Results: Our meta-analysis revealed that the carriers rs153109 A>G polymorphism in the IL-27 gene have higher risks of diseases in the heterozygous (OR=1.26, 95%CI=1.06-1.49, P=0.007, AG vs AA), homozygous (OR=1.18, 95%CI=1.01-1.37, p=0.33, GG vs AA), dominant (OR=1.25, 95%CI=1.07-1.47, P=0.006, AG+GG vs AA), and allele (OR=1.15, 95%CI=1.04-1.27, P=0.008, G vs A) genetic models. Stratified analysis by cancer type indicated that this variant was significantly associated with gastrointestinal cancer, colorectal cancer and breast cancer. The findings did not support an association between rs17855750 T>G, rs181206 T>C polymorphisms of IL-27 and cancer risk. Conclusion: the current study findings suggest that IL-27 rs153109 polymorphism significantly increased the risk of cancer susceptibility. Well-designed replication in a larger independent genetic association study with larger sample sizes in diverse ethnicities is required to verify the findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Moazeni‐Roodi

Hashemi

Ghavami

2020

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…Currently, there are no studies on the relationship between autoimmune polyglandular syndromes and IL27 polymorphisms, and more studies are needed to explore the relationship between them in the future. Existing studies reported that rs153109 AG and AG/GG genotypes, rs17855750 GT and GT/GG genotypes of IL27 gene significantly increased the risk of PTC, both rs153109 and rs17855750 of IL27 gene contributed to the increased risk of PTC (22). Moreover, there is another study which showed that rs153109 of IL27 gene may be associated with the decreased risk for lymph node metastasis of PTC (39).…”

Section: Discussionmentioning

confidence: 99%

“…AITD patients were recruited from Department of Endocrinology, Jinshan Hospital of Fudan University. The inclusion criteria of all patients have been described previously (12, 22). Both GD and HT were diagnosed according to the international diagnostic criteria (14).…”

Section: Methodsmentioning

confidence: 99%

Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases

Wang

et al. 2019

Endocrine Connections

View full text Add to dashboard Cite

Background Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Methods Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 Graves’ disease (GD) and 327 Hashimoto’s thyroiditis (HT)) and 677 healthy controls in Chinese Han population. Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206. Conclusion Our study, for the first time, showed the significant association of the IL27 gene SNPs with AITD.

show abstract

“…TC led the fifth most common cancer in women in the United States [2], while the estimates of cancer incident cases and deaths were 143.9 thousand and 6500 respectively in China [3]. Although the exact pathophysiologic mechanisms of TC remained elusive, accumulating evidence indicated that the inter-individual genetic factors, especially the single nucleotide polymorphisms (SNPs) in tumor-associated genes took essential part in the genetic susceptibility to TC [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Influence of Interleukin-18 and Interleukin-17 Receptor A gene polymorphisms on the risk of thyroid cancer among Chinese Han population

Yin

Tong

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Thyroid cancer (TC) is a common endocrine pathology with an increasing incidence worldwide. It has been reported that high genetic impact is involved in the pathogenesis of TC, as well as cytokines, especially the interleukins play a crucial role in it. This study was designed to detect the association of IL-18 and IL-17RA polymorphisms with TC risk.Methods This case-control study conducted 365 TC patients and 503 healthy controls from Chinese Han population. Three selected SNPs (IL-18 rs360718, IL-18 rs1946519, and IL-17RA rs4819554) were genotyped to investigate the possible association of the polymorphisms with the risk of TC. Multifactor dimensionality reduction (MDR) was used to analyze the interactions of SNP-SNP.Results IL-17RA rs4819554 was associated with the decreased risk of TC under dominant model (OR = 0.76, 95% CI = 0.56-0.99, p = 0.04). IL-18 rs360718 significantly decreased the risk at age ≤ 44 years (C vs. A, OR = 0.63, 95% CI = 0.41-00.97, p = 0.033; CC vs. AA, OR = 0.12, 95% CI = 0.01-0.91, p = 0.040). On the contrast, among people older than 44 years, IL-18 rs1946519 (C vs. A, OR = 1.77, 95% CI = 1.03-3.06, p = 0.040) shown an increased risk with TC. MDR analysis revealed a positive interaction between the SNPs.Conclusion The present study firstly demonstrated that IL-18 rs360718, rs1946519 and IL-17RA rs4819554 polymorphisms might be related to thyroid cancer. The results were significantly worthy of further validation by larger studies.

show abstract

Association Between IL-27 Gene Polymorphisms and Risk of Papillary Thyroid Carcinoma

Abstract: These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.

Cited by 14 publications

References 43 publications

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases

Influence of Interleukin-18 and Interleukin-17 Receptor A gene polymorphisms on the risk of thyroid cancer among Chinese Han population

Contact Info

Product

Resources

About