Association between
            <i>NOS3</i>
            polymorphisms and osteonecrosis of the femoral head

Zhao, Xiaodong; Yang, Fuqiang; Sun, Lihua; Zhang, Ali

doi:10.1080/21691401.2019.1593995

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…With the progress of molecular technology, the amount of research studies have observed the genetic factors, such as glutamate receptor gene [ 9 ], single nucleotide polymorphisms and transient receptor potential vanilloid 4 gene [ 10 ], and nitric oxide synthase 3 gene [ 11 ], have been accepted to influence the etiology of ONFH. In recent years, an increasing number of studies have manifested that microRNAs have been directly in the regulation of bone development and regeneration in orthopedic diseases, such as osteosarcoma [ 12 ], knee osteoarthritis [ 13 ], and lumbar disc herniation [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Integrated Analysis of miRNA-mRNA Regulatory Networks Associated with Osteonecrosis of the Femoral Head

Yu¹,

Yao

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Osteonecrosis of the femoral head (ONFH) accounts for as many as 18% of total hip arthroplasties. Knowledge of genetic changes and molecular abnormalities could help identify individuals considered to be at a higher risk of developing ONFH. In this study, we sought to identify differentially expressed miRNAs (DEmiRs) and genes (DEGs) associated with ONFH by integrated bioinformatics analyses as well as to construct the miRNA-mRNA regulatory network involving in the pathogenesis of ONFH. We performed differential expression analysis using a gene expression profile GSE123568 and a miRNA expression profile GSE89587 deposited in the Gene Expression Omnibus and identified 47 DEmiRs (24 upregulated miRNAs and 23 downregulated miRNAs) and 529 DEGs (218 upregulated genes and 311 downregulated genes). Gene Ontology enrichment analyses of DEGs suggested that DEGs were significantly enriched in neutrophil activation, cytosol, and ubiquitin-protein transferase activity. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of DEGs revealed that DEGs were significantly enriched in transcriptional misregulation in cancer. DEGs-based miRNA-mRNA regulatory networks were obtained by searching miRNA-mRNA prediction databases, TargetScan, miTarBase, miRMap, miRDB, and miRanda databases. Then, overlapped miRNAs were selected between these putative miRNAs and DEmiRs between ONFH and non-ONFH, and pairs of the DEmiR-DEG regulatory network were finally depicted. There were 12 nodes and 64 interactions for upDEmiR-downDEG regulatory networks and 6 nodes and 16 interactions for downDEmiR-upDEG regulatory networks. Using the STRING database, we established a protein-protein interaction network based on the overlapped DEGs between ONFH and non-ONFH. C5AR1, CDC27, CDC34, KAT2B, CPPED1, TFDP1, and MX2 were identified as the hub genes. The present study characterizes the miRNA profile, gene profile, and miRNA-mRNA regulatory network in ONFH, which may contribute to the interpretation of the pathogenesis of ONFH and the identification of novel biomarkers and therapeutic targets for ONFH.

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Section: Introductionmentioning

confidence: 99%

Integrated Analysis of miRNA-mRNA Regulatory Networks Associated with Osteonecrosis of the Femoral Head

Yu¹,

Yao

Jiang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Notably, for some cases, even small doses of corticosteroid could cause osteonecrosis and genetic predisposition may contribute the result. Genetic polymorphisms in many genes including SERPINE1, VEGF, VDR, CYP3A4, ACP1, and NOS3 are reported to be associated with ONFH [23]. These genes also play an important role in MM susceptibility and drug effects.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens

Geng²,

Sun

et al. 2020

BioMed Research International

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Objectives. To investigate the incidence and risk factors for osteonecrosis of femoral head (ONFH) in multiple myeloma (MM) patients undergoing dexamethasone-based regimens (DBRs). Methods. A retrospective study was conducted in MM patients administered DBRs between December 2012 and April 2015. Demographic, clinical, and laboratory data were extracted to compare between two groups. Incidence of ONFH were calculated and risk factors identified by both univariate and multivariate analysis. Results. The study group comprised 105 patients undergoing DBRs. Seven patients with ONFH after DBRs were classified as the ONFH group, and the other 98 patients without ONFH were included in the non-ONFH group. Incidence of ONFH was 6.7%. Median age of developing ONFH was 51 years (45–64), and the male to female ratio was 6 : 1. A total of 12 femoral heads were involved, including unilateral in 2 patients and bilateral in 5 patients. After the multivariate analysis, four risk factors were confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia. Conclusion. The overall incidence of ONFH in MM patients treated with DBRs is 6.7%, and 4 risk factors are confirmed including male, younger age, cumulative dose of dexamethasone, and hyperlipidemia in our study.

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“…Up to now, the role of genetic polymorphisms in the development of ONFH has been widely reported. For example, Zhao et al found that NOS3 variants were associated with the occurrence of ONFH [8]. A meta-analysis by Song et al showed that eNOS polymorphism was correlated with idiopathic and secondary ONFH in Caucasians and Asians [9].…”

Section: Introductionmentioning

confidence: 99%

An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

Wang

Liu

2022

BMC Med Genomics

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Background Genetic polymorphisms play a crucial role in the development of osteonecrosis of the femoral head (ONFH). This study mainly explored the association of IL-6 variants and ONFH susceptibility among the Chinese Han population. Methods Two variants (rs2069837, and rs13306435) in the IL-6 gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between IL-6 polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The potential function of these two variants was predicted by the HaploReg online database. Results The results of the overall analysis revealed that IL-6 rs2069837 was correlated with decreased risk of ONFH among the Chinese Han population (p < 0.05). In stratified analysis, rs2069837 also reduced the susceptibility to ONFH in older people (> 51 years), males, nonsmokers, and nondrinkers (p < 0.05). However, no associations between rs13306435 and ONFH susceptibility were observed (p > 0.05). Conclusions To sum up, we suggested that rs2069837 G>A polymorphism in the IL-6 gene was significantly associated with a decreased risk of ONFH among the Chinese Hans. These findings underscored the crucial role of IL-6 rs2069837 in the occurrence of ONFH.

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Association between NOS3 polymorphisms and osteonecrosis of the femoral head

Cited by 13 publications

References 35 publications

Integrated Analysis of miRNA-mRNA Regulatory Networks Associated with Osteonecrosis of the Femoral Head

Integrated Analysis of miRNA-mRNA Regulatory Networks Associated with Osteonecrosis of the Femoral Head

Incidence and Risk Factors of Osteonecrosis of Femoral Head in Multiple Myeloma Patients Undergoing Dexamethasone-Based Regimens

An intron SNP rs2069837 in IL-6 is associated with osteonecrosis of the femoral head development

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