Association between ICAM-1 level and diabetic retinopathy: a review and meta-analysis

Yao, Yang; Du, Junhui; Li, Rong; Zhao, Lei; Luo, Na; Zhai, Jing; Long, Lihui

doi:10.1136/postgradmedj-2018-136102

Cited by 28 publications

(14 citation statements)

References 30 publications

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“…Intercellular adhesion molecule-1 (ICAM-1) is a member of the immunoglobulin supergene family with the ability of cellular adhesion molecules mediating the attachment of lymphocytes. Diabetes retinopathy patients in a meta-analysis research showed that ICAM-1 expression was related to the severity of diabetes retinopathy and generally exists in patients [34]. Our results are also consistent with the pathology of diabetes retinopathy, showing a decrease of tight junction-related protein expression and increased ICAM-1 in the high glucose-and 4-HNE-induced retinopathy.…”

Section: Discussionsupporting

confidence: 87%

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

et al. 2020

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The incidence of diabetes mellitus is increasing due to the eating and living habits of modern people. As the disease progresses, the long-term effects of diabetes can cause microvascular disease, causing dysfunction in different parts of the body, which, in turn, leads to different complications, such as diabetic neuropathy, diabetic nephropathy, and diabetic retinopathy (DR). DR is the main cause of vision loss and blindness in diabetic patients. Persistent hyperglycemia may cause damage to the retina, induce the accumulation of inflammatory factors, and destroy the blood–retinal barrier function. Fucoxanthin (Fx) is a marine carotenoid extracted from seaweed. It accounts for more than 10% of the total carotenoids in nature. Fx is mainly found in brown algae and has strong antioxidant properties, due to its unique biologically active structure. This carotenoid also has the effects of reducing lipid peroxidation, reducing DNA damage, and preventing cardiovascular diseases as well as anti-inflammatory and anti-tumor effects. However, there is no relevant research on the protective effect of Fx in DR. Therefore, in this study, we explore the protective effect of Fx on the retina. Human retinal epithelial cells (ARPE-19) are used to investigate the protective effect of Fx on high glucose stress- (glucose 75 mM) and high lipid peroxidation stress (4-hydroxynonenal, 4-HNE (30 μM))-induced DR. The cell viability test shows that Fx recovered the cell damage, and Western blotting shows that Fx reduced the inflammation response and maintained the integrity of the blood–retinal barrier by reducing its apoptosis and cell adhesion factor protein expression. Using an antioxidant enzyme assay kit, we find that the protective effect of Fx may be related to the strong antioxidant properties of Fx, which increases catalase and reduces oxidative stress to produce a protective effect on the retina.

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Section: Discussionsupporting

confidence: 87%

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

et al. 2020

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“…ICAM-1 is mainly expressed by EC and leukocytes, following cytokine stimulation. Leukocytes are involved in the pathogenesis of many retinal diseases, among which DR [24], and their adhesion is regulated by ICAM-1 and MCP-1 [23,24]. ICAM-1 is also involved in angiogenesis, as VEGF can enhance its expression [24].…”

Section: Discussionmentioning

confidence: 99%

“…Leukocytes are involved in the pathogenesis of many retinal diseases, among which DR [24], and their adhesion is regulated by ICAM-1 and MCP-1 [23,24]. ICAM-1 is also involved in angiogenesis, as VEGF can enhance its expression [24]. Increased MMP2 and MMP9 expression, and the concomitant reduction of TIMP1, as found in our cell models, are consistent with our previous findings showing dysregulation of the MMPs/TIMP1 system in HRPs due to high glucose damage [17], as well as increased MMP2 in the same cells exposed to extracellular vesicles released in diabetic-like conditions [18].…”

Section: Discussionmentioning

confidence: 99%

Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier

et al. 2020

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Aims: Although diabetic retinopathy has long been considered a microvascular complication, retinal neurodegeneration and inflammation may precede its clinical manifestations. Despite all research efforts, the primary treatment options remain laser photocoagulation and anti-vascular endothelial growth factor (VEGF) intravitreal injections, both aggressive and targeting the late stages of the disease. Medical treatments addressing the early phases of diabetic retinopathy are therefore needed. We aimed at verifying if thiamine and fenofibrate protect the cells of the inner blood-retinal barrier from the metabolic stress induced by diabetic-like conditions. Methods: Human microvascular endothelial cells (HMECs), retinal pericytes (HRPs) and Müller cells (MIO-M1) were cultured in intermittent high glucose (intHG) and/or hypoxia, with addition of fenofibrate or thiamine. Modulation of adhesion molecules and angiogenic factors was addressed. Results: Integrins β1/αVβ3 and ICAM1 were upregulated in HMECs/HRPs cultured in diabetic-like conditions, as well as metalloproteases MMP2/9 in HRP, with a reduction of their inhibitor TIMP1; MMP2 increased also in HMEC, and TIMP1 decreased in MIO-M1. VEGF and HIF-1α were strongly increased in HMEC in intHG+hypoxia, and VEGF also in HRP. Ang-1/2 augmented in HMEC/MIO-M1, and MCP-1 in HRP/MIO-M1 in intHG+hypoxia. Thiamine was able to normalize all such abnormal modulations, while fenofibrate had effects in few cases only. Conclusions: We suggest that endothelial cells and pericytes are more affected than Müller cells by diabetic-like conditions. Fenofibrate shows a controversial behavior, potentially positive on Müller cells and pericytes, but possibly detrimental to endothelium, while thiamine confirms once more to be an effective agent in reducing diabetes-induced retinal damage.

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“…In the pathogenesis of DR hyperglycaemia is the causative factor, causing a series of reactions that include the increase in the production of catabolic products of glycosylation, the activation of the metabolism of the polyol pathway and the altered transduction of cellular signals (Yao et al, 2019). The damage to the pericytes, mesenchymal cells with contractile function that partially surrounds the endothelial cells, results in an imbalance in the mechanisms of regulation of flow controls with consequent hypoxia and accumulation of fluid inside the retinal tissue (Sinclair and Schwartz, 2019) as reported in this recent study.…”

Section: Mechanisms Underlying Diabetic Retinopathymentioning

confidence: 99%

Focus on Diabetic Retinopathy (DR) and MicroRNA “What Association”

Puccio¹,

Caroleo²,

Giampà³

et al. 2021

FMCR

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Diabetes Mellitus (DM) is one of the most common chronic diseases in the world. According to the latest data from the International Diabetes Federation, it is estimated that around 700 million will develop DM by 2045! Glycemic control is crucial in the management of DM and for the prevention of microvascular "nephropathy, retinopathy, neuropathy" and macrovascular complications. Of all the microvascular complications, the one that aroused most interest in our descriptive study was Diabetic Retinopathy (DR), since, if left untreated, it leads to irreversible anatomical and functional damage. DR is the leading cause of blindness in working-age adults across the world. The pathogenesis of DR is multifactorial and the molecular mechanisms are still not fully understood. The treatment of DR essentially involves laser therapy, which is not always decisive due to absence and/or limited availability of successful drug therapies for these blinding disorders. The clinical diagnosis of DM often occurs late and this delay means that the chronic vascular complications associated with the disease are already present at the time of diagnosis. Therefore, this risk can be reduced if an early diagnosis is made. Hence the need to identify new specific biomarkers that can act as diagnostic and prognostic indicators of the disease.According to some studies, putative roles of small endogenous molecules of microRNAs as indicators of DR and associated complications are being considered. They carry out their silencing activity on a wide range of transcripts deriving from the expression of thousands of genes.There is evidence for the aberrant expression of microRNAs implicated in the onset of numerous pathologies. Since most of the genetic variations associated with diabetes are found in regions of the human genome that are not coding for proteins, it is worth studying those microRNAs involved in DR, both as possible therapeutic targets and as specific predictive diagnostic biomarkers. The present study aims to highlight the importance of some microRNAs and indicate those most implicated in the onset of DR, according to the literature, for the purpose of making a previous diagnosis of diabetes, in particular of DR.

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Association between ICAM-1 level and diabetic retinopathy: a review and meta-analysis

Cited by 28 publications

References 30 publications

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

Protective Effects of Fucoxanthin on High Glucose- and 4-Hydroxynonenal (4-HNE)-Induced Injury in Human Retinal Pigment Epithelial Cells

Effects of thiamine and fenofibrate on high glucose and hypoxia-induced damage in cell models of the inner blood-retinal barrier

Focus on Diabetic Retinopathy (DR) and MicroRNA “What Association”

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