Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case–Control Study and Meta-Analysis

Abstract

Background: Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) risk. Many studies have replicated this association, but yielded inconsistent results. Materials and Methods: A case-control study consisting of 461 T2DM patients and 434 health controls was conducted to detect the genetic susceptibility of IGF2BP2 in a northern Han Chinese population. A meta-analysis was to evaluate the association more precisely in Asians. Results: In the case-control study, the carriers of TT genotype at rs4402960 had a higher T2DM risk than the G carriers (TG + GG) (adjusted odd ratio (AOR) = 1.962, 95% confidence interval (95% CI) = 1.065–3.612, p = 0.031]; CC carriers at rs1470579 were more susceptible to T2DM than A carriers (CA + AA) (AOR = 2.014, 95% CI = 1.114–3.642, p = 0.021). The meta-analysis containing 36 studies demonstrated that the two polymorphisms were associated with T2DM under the allele comparison, genetic models of dominant and recessive in Asians (p < 0.05). The rs4402960 polymorphisms were significantly associated with the T2DM risk after stratification by diagnostic criterion, size of sample and average age and BMI of cases, while there’re no consistent results for rs1470579. Conclusions: Our data suggests that IGF2BP2 polymorphisms are associated with T2DM in Asian populations.

Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray

“…Its pathway-related gene IGFBP2 was shown to be linked to impaired β-cell function and T2DM [17] . The hsa_circRNA_100750 is spliced from stromal interaction molecule 1, which was upregulated in glomerular mesangial cells treated with high glucose [18] and aortae from streptomycin-induced mice and diabetic patients [19] .…”

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

“…After adjustment for BMI, gender, sex, alcohol use, and smoking status, this association was more significant (GG vs AA: adjusted OR = 1.88, 95% CI = 1.02-3.46, P = 0.042 and GG vs AA/AG: adjusted OR = 1.92, 95% CI = 1.06-3.47, P = 0.032). 29 Several case-control studies assessed the potential association of IGF2BP2 rs1470579 A > C variants with T2DM susceptibility and therapeutic efficacy in the Chinese population. [3][4][5] Thus, the variants in energy metabolism-related gene may influence the susceptibility of EGJA.…”

Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications

“…Dysregulation of RBPs has been observed in a plethora of diseases including cancer (reviewed in Castello et al, 2013;Gerstberger et al, 2014), neurological (reviewed in Cookson, 2017;Donlin-Asp, Rossoll, & Bassell, 2017), and cardiovascular diseases (reviewed in de Bruin, Rabelink, van Zonneveld, & van der Veer, 2017;Nutter et al, 2016;Verma et al, 2016;Xin, Deng, & Fu, 2014). Several RBPs have been associated with the development of diabetes or with diabetic complications (Ben-Haim, Moshitch-Moshkovitz, & Rechavi, 2015;Chu et al, 2008;Gerken et al, 2007;Lyssenko et al, 2008;Rao et al, 2016;Scott et al, 2007;van Hoek et al, 2008;Wood et al, 2016). RBPs that are implicated in diabetes are summarized in Table 1.…”