Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond

Pușcaș, Alexandra Dana; Morar, I.; Vesa, Ştefan Cristian; Cătană, Andreea; Pușcaș, Cristian; Ilieş, Roxana Flavia; Orasan, Remus-Ioan

doi:10.3390/genes14051123

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Насчитывается более 30 однонуклеотидных полиморфизмов (SNPs), вносящих свой вклад в риск развития псориаза. В частности установлены ассоциации псориаза с полиморфизмами: (SNP) rs2275913 в гене IL-17A, SNP rs3212227 в гене IL-12B, SNP rs1800872 в гене IL- 10 [6,7,8,9]; SNP rs763780 в IL-17F и rs4819554 в гене IL-17RA [10]; SNP в IL36G (rs28947206, rs28947207 и rs28947211) [11]; SNP в IL-23 (rs11209026G> A) [1], IL-12B (rs3212227) и IL-23R (rs2201841); а также SNP -308G>A (rs1800629) и -238G>A (rs361525) гена TNF [12].…”

Section: Introductionunclassified

Polymorphism of cytokine and C-reactive protein genes in patients with psoriasis in the Kemerovo region of Russia

Romanova,

Shabaldin,

Belov

et al. 2023

Immunopathol Allergol Infectol

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Aim. To study the associations of polymorphisms of IL-1b (rs16944), IL-6 (rs1554606), IL-8 (rs2227306), IL-10 (rs1800896), TNFα (rs361525), CRP (rs1205) genes and their intergenic interactions with the risk of psoriasis development in Kemerovo region residents. Materials and Methods. We examined 170 patients (102 men and 78 women) a clinically established diagnosis of vulgar psoriasis. The average age of patients was 46.2+3.9 years, 165 people (97%) had progressive stage psoriasis. The control group (n=155) included 98 healthy men and 57 women matched by age. Genomic DNA isolated from peripheral blood leukocytes by phenol-chloroform extraction according to the standard protocol was used as material. Logistic regression analysis was performed to assess the role of intergenic interactions in the development of psoriasis. Conclusion. In patients of the Kemerovo region, vulgar psoriasis is associated with minor homozygous genotypes of polymorphic variants of TNFα (rs361525), IL-1b (rs16944), CRP (rs1205) genes. The minor homozygous TNFα (rs361525) genotype has a high odds ratio and is determinant in the development of this form of psoriasis among all genes studied. The major allele and IL-10 genotype (rs1800896) is a disease modifier and affects the clinical course, particularly the development of inflammatory plaques and papules on the lower and upper extremities of patients.

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Section: Introductionunclassified

Polymorphism of cytokine and C-reactive protein genes in patients with psoriasis in the Kemerovo region of Russia

Romanova,

Shabaldin,

Belov

et al. 2023

Immunopathol Allergol Infectol

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Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Najar,

Rahmani,

Faour

et al. 2024

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As a form of immunomodulatory therapeutics, mesenchymal stromal/stem cells (MSCs) from umbilical cord (UC) tissue were assessed for their dynamic interplay with the Th-17 immune response pathway. UC-MSCs were able to modulate lymphocyte response by promoting a Th-17-like profile. Such modulation depended on the cell ratio of the cocultures as well as the presence of an inflammatory setting underlying their plasticity. UC-MSCs significantly increased the expression of IL-17A and RORγt but differentially modulated T cell expression of IL-23R. In parallel, the secretion profile of the fifteen factors (IL1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-22, IL-21, IL-23, IL-25, IL-31, IL-33, INF-γ, sCD40, and TNF-α) involved in the Th-17 immune response pathway was substantially altered during these cocultures. The modulation of these factors demonstrates the capacity of UC-MSCs to sense and actively respond to tissue challenges. Protein network and functional enrichment analysis indicated that several biological processes, molecular functions, and cellular components linked to distinct Th-17 signaling interactions are involved in several trophic, inflammatory, and immune network responses. These immunological changes and interactions with the Th-17 pathway are likely critical to tissue healing and may help to identify molecular targets that will improve therapeutic strategies involving UC-MSCs.

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Intercommunicating avenues – cytokine networks in psoriasis Mihaela Surcel1, Adriana Narcisa Munteanu12,

Surcel,

Munteanu,

Constantin

et al. 2024

JCI

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Psoriasis is a systemic autoimmune disease in which skin’s cells, keratinocytes, are hyper-activated and would actively secrete various immune molecules inducing the disease’s immunopathogenesis. We are discussing herein the complex array of cytokine and chemokines that are intertwining and the mechanisms that are involved in Ps development along with our experience regarding the contribution of pro- and anti-inflammatory cytokines/chemokines in this autoimmune disease. We are presenting the cytokine network grouped by their action and regardless their origin, i.e. secreted by immune or non-immune cells. Moreover, we are discussing their molecular relationship that sustains cells’ cross-talk in the development of psoriasis.

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Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond

Cited by 3 publications

References 48 publications

Polymorphism of cytokine and C-reactive protein genes in patients with psoriasis in the Kemerovo region of Russia

Polymorphism of cytokine and C-reactive protein genes in patients with psoriasis in the Kemerovo region of Russia

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Intercommunicating avenues – cytokine networks in psoriasis Mihaela Surcel1, Adriana Narcisa Munteanu12,

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