Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Cardoso, José Maria; Duarte, Sofia Alexandra Ferreira; Ribeiro, Ana Clara; Mascarenhas, Paulo; Noronha, Susana; Alves, Ricardo

doi:10.3390/app12146958

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…IL-1β is an important cytokine for the differentiation of Th-17 cells with multiple signaling effects, including RORγt expression [55]. IL-1β is a proinflammatory cytokine that plays a significant role in the immune response and inflammatory processes [56]. IL-1β triggers the production of other cytokines, including IL-6 and IL-23 [57].…”

Section: Discussionmentioning

confidence: 99%

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Najar,

Rahmani,

Faour

et al. 2024

Cells

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As a form of immunomodulatory therapeutics, mesenchymal stromal/stem cells (MSCs) from umbilical cord (UC) tissue were assessed for their dynamic interplay with the Th-17 immune response pathway. UC-MSCs were able to modulate lymphocyte response by promoting a Th-17-like profile. Such modulation depended on the cell ratio of the cocultures as well as the presence of an inflammatory setting underlying their plasticity. UC-MSCs significantly increased the expression of IL-17A and RORγt but differentially modulated T cell expression of IL-23R. In parallel, the secretion profile of the fifteen factors (IL1β, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-22, IL-21, IL-23, IL-25, IL-31, IL-33, INF-γ, sCD40, and TNF-α) involved in the Th-17 immune response pathway was substantially altered during these cocultures. The modulation of these factors demonstrates the capacity of UC-MSCs to sense and actively respond to tissue challenges. Protein network and functional enrichment analysis indicated that several biological processes, molecular functions, and cellular components linked to distinct Th-17 signaling interactions are involved in several trophic, inflammatory, and immune network responses. These immunological changes and interactions with the Th-17 pathway are likely critical to tissue healing and may help to identify molecular targets that will improve therapeutic strategies involving UC-MSCs.

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Section: Discussionmentioning

confidence: 99%

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Najar,

Rahmani,

Faour

et al. 2024

Cells

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“…An example of this is periimplantitis, a growing problem that requires better approaches in terms of prevention and treatment. Cardoso et al [1] carried out a systematic review via a meta-analysis with the aim of evaluating the association between IL-1A, IL-1B and IL-1RN polymorphisms and periimplantitis. The results showed that patients who have the polymorphic allele at position +3954 of the IL-1B gene have on average almost twice the risk of developing peri-implantitis.…”

Section: New Techniques Materials and Technologies In Dentistrymentioning

confidence: 99%

Special Issue on New Techniques, Materials and Technologies in Dentistry

Alves,

Mendes,

Azul

2023

Applied Sciences

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“…Current research avenues are directed towards supplementary, non-invasive techniques, where early detection of pathological biological activities is possible. Furthermore, innovations in implant dentistry have been documented in the quest to reduce morbidity, biological complications, and surgical times [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

Moaven

Giacaman

Beltrán

et al. 2022

IJERPH

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The need to predict, diagnose and treat peri-implant diseases has never been greater. We present a systematic review of the literature on the changes in the expression of biomarkers in peri-implant crevicular fluid (PICF) before and after treatment of peri-implantitis. Bacterial composition, clinical and radiographic parameters, and systemic biomarkers before and after treatment are reported as secondary outcomes. A total of 17 studies were included. Treatment groups were non-surgical treatment or surgical treatment, either alone or with adjunctive therapy. Our findings show that non-surgical treatment alone does not influence biomarker levels or clinical outcomes. Both adjunctive photodynamic therapy and local minocycline application resulted in a reduction of interleukin (IL)-1β and IL-10 twelve months after treatment. Non-surgical treatments with adjunctive use of lasers or antimicrobials were more effective at improving the clinical outcomes in the short-term only. Access flap debridement led to matrix metalloproteinase (MMP)-8 and tumour necrosis factor-α reduction twelve months post-surgery. Surgical debridement with adjunctive antimicrobials achieved a decrease in MMP-8 at three months. Adjunctive use of Emdogain™ (EMD) was associated with a reduction in 40 PICF proteins compared to access flap surgery alone. Surgical interventions were more effective at reducing probing pocket depth and bleeding on probing both in the short- and long-term. Surgical treatment in combination with EMD was found to be more effective in resolving inflammation up to twelve months.

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Association between IL-1A, IL-1B and IL-1RN Polymorphisms and Peri-Implantitis: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 39 publications

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Umbilical Cord Mesenchymal Stromal/Stem Cells and Their Interplay with Th-17 Cell Response Pathway

Special Issue on New Techniques, Materials and Technologies in Dentistry

Biomarker Expression of Peri-Implantitis Lesions before and after Treatment: A Systematic Review

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