Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Moazeni‐Roodi, Abdolkarim; Hashemi, Mohammad; Ghavami, Saeid

doi:10.31557/apjcp.2020.21.9.2507

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…Ghavami et al [ 39 ] evaluated one genetic polymorphism located in the IL-27 gene, A964G , in patients with acute lymphoblastic leukemia (ALL) and demonstrated a higher risk to develop ALL for patients presenting the AG heterozygous genotype and G allele, a greater relapse rate and a worse therapeutic response for these patients. Similar results were obtained by Pu et al in patients with renal cancer and in patients with colorectal cancer, Moazeni-Roodi et al in a meta-analysis including patients with gastrointestinal cancer, colorectal cancer and breast cancer, Jahantigh et al in preeclamptic women [ 35 , 71 , 72 , 73 ].…”

Section: Discussionsupporting

confidence: 83%

Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level

Barac

Iancu

Văcăraș

et al. 2021

JCM

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(1) Background: interleukin 23 (IL-23) and interleukin 27 (IL-27) modulate the activity of T helper 17 cells (Th17) with critical roles in autoimmune diseases and multiple sclerosis (MS). The genes responsible for cytokine generation are highly influenced by the presence of single nucleotide polymorphisms (SNP) in main regions such as regulatory sequences or in promoter regions, contributing to disease susceptibility and evolution. The present study analyzed the associations of IL-23 and IL-27 SNPs with susceptibility to multiple sclerosis. (2) Methods: We performed a case-control study including 252 subjects: 157 patients diagnosed with MS and 95 controls. We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to determine the genotypes for IL-27 T4730С (rs 181206), IL-27 A964G (rs 153109), and IL-23 receptor gene (IL-23R) G1142A (rs 11209026). (3) Results: The IL27-T4730С gene polymorphism was significantly associated with an increased odds of MS under the dominant genetic model (TC + CC variant genotypes, adjusted odds ratio OR = 4.06, 95% CI: 2.14–7.83, p-value = 0.000007, Q-value = 0.000063). Individuals carrying the IL-27 A924G variant (AG + GG) genotype presented higher odds of MS compared to non-carriers under the dominant model (adjusted OR = 1.93, 95% CI: 1.05–3.51, p-value = 0.0324, Q-value = 0.05832) and the allelic genetic model (unadjusted p-value = 0.015, OR = 1.58, 95% CI: 1.09–2.28), while IL-23-R381Q SNP conferred a decreased odds of MS under a codominant model of inheritance (adjusted OR = 0.26, 95% CI: 0.08–0.92, p-value = 0.0276, Q-value = 0.058) and an allelic model (unadjusted p-value = 0.008, OR = 0.23, 95% CI: 0.07–0.75). In an additive model with adjustment for age group (≤40 years vs. >40 years), sex and smoking, patients carrying the G-C (A964G, T4730C) haplotype had a 3.18 increased risk (95% CI: 1.74–5.81, p < 0.001) to develop multiple sclerosis. (4) Conclusions: The results of the current study showed a significant relationship of IL-27-A964G and IL-27-T4730C polymorphisms with increased risk of MS, and also the protective role of the IL-23-R381Q polymorphism. Moreover, the haplotype-based analysis proposed the mutant G-C (A924G, T4730C) as a significant risk haplotype for the development of MS.

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Section: Discussionsupporting

confidence: 83%

Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level

Barac

Iancu

Văcăraș

et al. 2021

JCM

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“…Most of these studies have shown that the IL-27 rs153109 polymorphism significantly increases the risk of developing cancer. 34 However, no association was found between serum IL-27 levels and IL-27 polymorphisms. In a study conducted by Yu Jin Tong in patients with osteosarcoma, no significant relationship was observed be-tween rs181206 and rs153109 polymorphisms and IL-27 serum levels.…”

Section: Discussionmentioning

confidence: 99%

Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis

Koohyanizadeh,

Falahi,

Mortazavi

et al. 2023

Gene Expr

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Background and objectives: Interleukin 27 (IL-27) is a cytokine consisting of two subunits, p28 and EBI3, and is a key mediator in regulating the differentiation of TCD4 + cells while playing a crucial role in immune-related disorders. This study aims to elucidate the possible association between IL-27p28 single nucleotide polymorphisms (SNPs), IL-27 serum levels, and the risk of allergic rhinitis (AR). Materials and methods:Blood samples were collected from 130 patients with AR and 130 healthy individuals, and DNA and serum were separated. The relationship between IL-27p28 SNPs (rs153109 and rs181206) and the risk of AR was evaluated using the polymerase chain reaction-restriction fragment length polymorphism method. The serum levels of IL-27 in the participants were determined using enzyme-linked immunosorbent assay.Results: Our results did not show a significant relationship between IL-27p28 SNPs (rs153109 and rs181206) and the risk of AR or serum IL-27 levels. However, our results showed a significant decrease in the serum level of IL-27 in patients with AR (342 ± 299 pg/mL) compared to healthy subjects (455 ± 274 pg/mL) (p = 0.02). Conclusion:Our results suggest that IL-27p28 SNPs (rs181206 and rs153109) are not associated with susceptibility to AR, but that decreased serum IL-27 levels may be associated with the development of AR.

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“…It is primarily produced by activated antigen-presenting cells and acts on T cells, NK cells, and other immune cells, thus regulating anti-tumor immunity through various mechanisms. A clinical metaanalysis [28] found that the IL-27 gene rs153109 polymorphism increases tumor susceptibility, and IL-27 gene rs153109 A>G polymorphism carriers have a higher risk of disease in heterozygotes, which is signi cantly associated with breast cancer. Lu et al [29] also showed that breast cancer patients had a signi cantly higher serum IL-27 level than healthy controls, and the serum IL-27 level was closely related to the clinical stage of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Natural killer cells are associated with prognosis in triple-negative breast cancer patients

Zhang

et al. 2022

Preprint

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Objective:Immune cells play an important role in anti-tumor activity. We aimed to investigate the expression of CD4+ and CD8+ T cells, natural kill (NK) cells, and interleukin-27 (IL-27) in breast cancer tissues, and to explore their relationship with clinical characteristics and patients’ prognoses.Methods:Immunohistochemistry was used to detect the expression levels of CD4+ and CD8+ T cells, NK cells, and IL-27 in a total of 198 breast cancer patients.Results:It was found that the number of positive NK cells was highest in patients with triple negative breast cancer (TNBC). In the Luminal A breast cancer group: the higher the histological grade, the higher the number of positive cases of CD4+ T cells; the higher the clinical stage, the higher the percentage of positive CD8+ T cells. In the Luminal B breast cancer group: the higher the histological grade, the higher the number of positive cases of CD8+ T cells; the higher the clinical stage, the higher the number of positive cases of CD8+ T cells. In the grouping of HER-2 breast cancer, patients with lymph node metastasis had higher CD8+ T cell positive cases; larger tumor volume had higher IL-27 positive cases. In TNBC grouping: the larger the tumor volume, the higher the positive ratio of CD8+ T cells; the higher the number of NK cell positive cases in patients with lymph node metastasis; the higher the number of IL-27 positive cases in patients with larger tumor volume. The survival curve showed that the OS rate of NK cell-negative patients was significantly higher than that of NK cell-positive patients.Conclusion:This study shows that infiltrating CD4+ and CD8+ T cells and NK cells in breast cancer tissue are associated with poor patient prognosis, and NK cell-positive TNBC patients with poor prognosis.

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Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis

Cited by 5 publications

References 36 publications

Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level

Potential Contribution of IL-27 and IL-23 Gene Polymorphisms to Multiple Sclerosis Susceptibility: An Association Analysis at Genotype and Haplotype Level

Correlation between IL-27p28 Genetic Polymorphisms and Risk of Allergic Rhinitis

Natural killer cells are associated with prognosis in triple-negative breast cancer patients

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