Association between IL-6 Gene (−174 &amp; -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk

Wang, Haiying; Zhang, Jinjun; Zheng, Xiangyu; Liu, Jianhua; Li, Yongwei

doi:10.1007/s12253-016-0073-6

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Several studies have demonstrated that SNPs in the -174 promotor region is associated with IL-6 gene transcription, which subsequently influences the expression and secretion of IL-6 (Jerrard-Dunne et al, 2004). For example, a IL-6 SNP in the -572 promoter region is the substitution of cytosine (C) by guanine (G) (Wang et al, 2016). This substitution may influence IL-6 gene transcription and expression level of IL-6, resulting in changes to disease susceptibility (Qi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Zhu¹,

Li²,

Li³

et al. 2017

Genet. Mol. Res.

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ABSTRACT. The aim of the present study is to explore the effect of IL-6 gene polymorphisms on the development of keloid scar (KS) in the Chinese Han population. Genotyping of IL-6 was performed by the polymerase chain reaction (PCR), followed by restriction fragment length polymorphism assays (PCR-RFLP). Serum level of IL-6 was measured using enzyme-linked immunosorbent assay (ELISA). Results indicated that when the IL-6 -572 CC homozygote genotype was used as the reference group, the GG genotype was found to be associated with a significantly increased risk of KS (GG vs CC: OR = 2.097, 95%CI = 1.100-3.995, P = 0.025). When the IL-6 -572 C allele was used as the reference group, the G allele was found to be associated with significantly increased risk of KS (G vs C: OR = 1.317, 95%CI = 1.002-1.730, P = 0.048). Furthermore, we observed a marked 2 X.J. Zhu et al. Genetics and Molecular Research 16 (2): gmr16029110 increase in serum IL-6 levels in KS patients with GG genotypes when compared to KS patients harboring the CC genotype. In conclusion, our results suggest that IL-6 gene polymorphism was associated with keloid scars in the southeastern Chinese Han population.

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Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Zhu¹,

Li²,

Li³

et al. 2017

Genet. Mol. Res.

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“…It was reported that the polymorphisms in rs3783553, rs3783550, rs3783546, rs1609682 and rs3783521 of IL-1α ( 138 , 139 ), rs1524107 and rs2066992 of IL-6 ( 140 ), rs4758680 and rs7977932 of IL-31 ( 141 ), rs28372698 and rs12934561 of IL-32 ( 2 ) may be relevant to increased susceptibility to EC in Chinese women. Moreover, the CC genotype of IL-6 Gene (−174 & -572) might contribute to EC risk ( 142 ).…”

Section: Clinical Application Of Interleukins In Ecmentioning

confidence: 99%

The roles and clinical applications of interleukins in endometrial carcinoma

Zang

Liu

et al. 2022

Front. Oncol.

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As a common malignant tumor of the female reproductive system, endometrial carcinoma (EC) seriously endangers women’s health with an increasing incidence. The oncogenesis and progression of cancer are closely linked with immune microenvironment, of which interleukins are the important components. In order to illustrate the roles and clinical applications of interleukins in EC, literature of interleukins and EC were reviewed. Based on the present studies, interleukins play crucial roles in the oncogenesis and development of EC via regulating the proliferation, migration, invasion, angiogenesis, apoptosis, pyroptosis and autophagy of EC as well as the immune function against EC. And some of the interleukins seems to have prospective clinical applications in EC, such as evaluating the risk of tumorigenesis, discriminating the malignancy from benign disorders or normal condition, indicating cancer aggressiveness, predicting the prognosis of patients and serving as the novel therapy. However, there is still a long way to go before the clinical applications of interleukins in EC come into reality. Nevertheless, it is certain that the exploration of interleukins will definitely be of great benefit to the screening, diagnosis and treatment of EC in the future.

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“…It has also indicated the proinflammatory milieu can directly increase estrogen production, which may facilitate carcinogenesis by disrupting the estrogen‐progesterone balance (Modugno, Ness, Chen, & Weiss, ). A growing number of studies reported that SNPs locus in interleukin (IL) genes, such as IL‐32 (Yu et al, ), IL‐6 (Wang, Zhang, Zheng, Liu, & Li, ), and IL1A (Yu et al, ), are associated with the risk endometrial cancer. Interleukin 1 receptor type 2 (IL‐1R2) is located on the long arm of human chromosome 2 at band 2q12, belongs to the interleukin 1 receptor family (Boraschi & Tagliabue, ).…”

Section: Introductionmentioning

confidence: 99%

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

Zhang

Cai

et al. 2019

Molec Gen & Gen Med

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Background Recently, many studies have identified that genetic factor plays a crucial role in endometrial cancer development. The purpose of this study is to investigate the influence of single nucleotide polymorphisms (SNPs) of IL‐1R2 on endometrial cancer susceptibility. Methods We performed a case‐control study that included 293 patients with endometrial cancer and 579 healthy controls. Six SNPs in the IL‐1R2 gene were genotyped using the Agena MassARRAY platform. Genetic models and haplotype analyses were used to assess the association between SNPs and endometrial cancer risk by computing odds ratios (ORs) and 95% confidence intervals (CIs). Results Overall analysis results found that two SNPs (rs4851527 and rs3218896) and haplotypes TGTC and TACT were significantly associated with endometrial cancer risk. Stratified analysis by age showed that rs2072472 was associated with endometrial cancer risk in age >54 subgroup. Conclusions These findings suggested that IL‐1R2 polymorphisms may contribute to the development of endometrial cancer. Further studies are required to confirm the results.

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Association between IL-6 Gene (−174 & -572 G/C) Polymorphisms and Endometrial Adenocarcinoma Risk

Cited by 4 publications

References 22 publications

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

Association of interleukin-6 gene polymorphisms and circulating levels with keloid scars in a Chinese Han population

The roles and clinical applications of interleukins in endometrial carcinoma

Influence of IL‐1R2 polymorphisms on endometrial cancer susceptibility in the Chinese Han population

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