Association between IL-6 polymorphisms and sepsis

Abstract

The aim of the present study was to determine whether IL-6 polymorphisms correlate with sepsis. According to the inclusion criteria, the association of IL-6 polymorphisms with sepsis was searched in databases and analysed using comprehensive meta-analysis software. A total of 16 studies were included in this meta-analysis. There was no significant association between the IL-6-174G/C polymorphism and sepsis risk in the total population (C vs. G: OR = 1.04, 95% CI = 0.79–1.38; CC vs. GG: OR = 0.86, 95% CI = 0.53–1.41; CG vs. GG: OR = 0.99, 95% CI = 0.79–1.24; dominant model: OR = 0.97, 95% CI = 0.74–1.29; recessive model: OR = 0.92, 95% CI = 0.61–1.39). When patients were stratified according to ethnicity, a statistically significant association was observed in Asians and Africans. As for the -572G/C polymorphism, the results showed that the IL-6-572C/G polymorphism was not associated with sepsis susceptibility (G vs. C: OR = 0.98, 95% CI = 0.79–1.22; GG vs. CC: OR = 1.46, 95% CI = 0.53–4.03; GC vs. CC: OR = 0.82, 95% CI = 0.54–1.27; dominant model: OR = 0.88, 95% CI = 0.55–1.41; recessive model: OR = 1.55, 95% CI = 0.82–2.92). The data indicated that the IL-6-174G/C polymorphism may contribute to sepsis risk, especially in Africans and Asians. No significant association was observed between the IL-6-572G/C polymorphism and sepsis risk.

Effects of Neutrophil-to-Lymphocyte Ratio Combined With Interleukin-6 in Predicting 28-Day Mortality in Patients With Sepsis

“…Whereas, NLR only reflects the change in the quantity of immune cells instead of functional change. As a crucial member of inflammatory cytokines, interleukin-6 (IL-6) can be produced by multiple immune cells and plays a pivotal role in host responses to infections by regulating immune function ( 20 – 22 ). Accordingly, combining NLR with IL-6 might potentially enhance the ability to predict the death risk of patients with sepsis.…”

MiR-539-5p inhibits the inflammatory injury in septic H9c2 cells by regulating IRAK3

“…IL-1 inhibits myocardial contractility by stimulating nitric oxide synthetase (NOS) [29]. IL-6, another proinflammatory cytokine, is also involved in the pathogenesis of sepsis and is considered to be a better predictor of sepsis than TNF-α [30]. Previous studies have shown that miRNAs exhibit important effects on LPS-induced sepsis.…”

Respiratory Burst and TNF-α Receptor Expression of Neutrophils after Sepsis and Severe Injury-Induced Inflammation in Children

“…In consequence, this results in tissue and organ impairment, and clinically the development of syndromes such as disseminated intravascular coagulation (DIC), adult respiratory distress syndrome (ARDS), or MODS [ 20 ]. It is worth mentioning that the following factors play an important role in SIRS pathogenesis: microorganism virulence, injury extensiveness, comorbidities in the patient, or gene polymorphism responsible for production of cytokines and other effectors of the immune response [ 10 , 21 , 22 ].…”

“…In a new approach to the SIRS concept, one of the main factors determining the development of the systemic inflammatory reaction and its further course is, among others, an individual susceptibility to develop sepsis affected by gene polymorphism, concerning, e.g., Toll-like receptors, cytokines (TNF-α, TNF-β, IL-1), or clotting factors [ 21 , 29 , 30 , 31 , 32 ]. These studies are aimed at revealing a relationship between a genotype determined by the examined gene polymorphism and severity and the further course of SIRS.…”