Association between immunoglobulin levels and known genetic markers in an Iraqi population

Al-Agidi, S.K.; Shukri, S. M.

doi:10.1080/03014468200006081

Cited by 5 publications

(3 citation statements)

References 4 publications

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“…There is no published information on the normal values of these "immunoproteins" in healthy adult Omanis and very little data on the Gulf Arabs in general. [1][2][3][4][5] Reports from elsewhere would indicate that there may be significant differences depending on race and environment. 6,7 We have studied 100 healthy adult Omanis (50 males/50 females) in order to obtain local reference values to be used when evaluating patients.…”

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confidence: 99%

Immunoglobulins, Immunoglobulin G Subclasses and Complement in Adult Omanis

White

Al-Riyami²,

Kuchipudi³

et al. 1997

Ann Saudi Med

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Immunoglobulins and complement were quantitated in 100 healthy adult Omanis in order to establish a reference range based on local data. Mean values were IgA 2.38 g/L, IgM 1.14 g/L, IgE 241 kiu/L, C3 7.44 mol/L and C4 1.57 mol/L, values similar to those found in the West. However, the mean level of IgG was almost 50% higher than that found in North America and Europe, that is, 14.63 g/L compared with 10-11 g/L. The values for IgG, IgA, IgM and IgE are similar to those reported for Iraq, but IgG levels were much lower than those found in Iran (25.52 g/L), although IgA, IgM and IgE were comparable. Comparison of Omani data with that for Saudi Arabia showed significantly more IgG in Oman (14.63 versus 11.68 g/L) and significantly less IgM (1.14 versus 1.66 g/L). IgA and IgE levels were similar. As reported elsewhere, females had significantly more IgM than males (1.32 versus 0.97 g/L). The levels of IgG subclasses in Oman are 9.44, 4.01, 1.06 and 0.62 g/L for IgG1-4 respectively. The percentage of the various subclasses are very similar to those reported elsewhere, that is, 62%, 27%, 7% and 4% for IgG1-4. However, in Iraq, a higher percentage (and level) of IgG3 (16%) and the lower IgG2 (18%) compared to Oman may reflect differing immune responses resulting from exposure to different microorganisms. It is essential to use local reference data when evaluating patients.

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confidence: 99%

Immunoglobulins, Immunoglobulin G Subclasses and Complement in Adult Omanis

White

Al-Riyami²,

Kuchipudi³

et al. 1997

Ann Saudi Med

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“…Non-secretion of ABH antigens has been associated with many non-communicable diseases and disorders [8][9][10][11][12][13][14][15][16][17]. Similarly, sickle cell anaemia individuals are known to have several complications including chronic pain, intermittent painful episodes, musculoskeletal problems, stroke, pulmonary hypertension and septicaemia [3,25].…”

Section: Discussionmentioning

confidence: 99%

“…Individuals can be homozygous (SeSe) or heterozygous (Sese) secretors or non-secretors (sese). Non-secretion of ABH antigens has been associated with a number of non-communicable diseases and disorders such as autoimmune diseases [8,9], blood clotting and thrombotic diseases [10,11], immunological disorders [12], myocardial infarction [13,14], rheumatic heart disease [15,16], duodenal ulcers [17]. Apart from one study [18] which investigated frequency distribution of secretors and non-secretors in HbAA and HbSS individuals in Zaria, Northwestern Nigeria, we are not aware of any other investigation that has related secretor status with haemoglobin variants.…”

Section: Introductionmentioning

confidence: 99%

Association between Non-secretion of ABH Antigens and Sickle Cell Anaemia

Igbeneghu

Olisekodiaka

Fawole

et al. 2019

JALSI

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Aim: To determine whether non-secretion of ABH blood group antigens was associated with Sickle Cell Anaemia. Materials and Methods: Haemaglutination inhibition test was carried out on saliva samples from 300 individuals; 100 of whom had haemoglobin (Hb) genotype AA, 100 HbAS, 50 HbAC and 50 HbSS. ABO blood grouping was carried out by standard methods and Haemoglobin genotype test was performed by cellulose acetate electrophoresis technique. Results: Eighteen percent (18%) of HbAA, 23% of HbAS, 18% of HbAC and 42% of HbSS individuals were non-secretors of ABH antigens (p = 0.007). Non-secretion of ABH substances was more associated with HbSS persons than HbAA (p = 0.002), HbAS (p = 0.016) and HbAC (p = 0.009) individuals. Conclusion: Non-secretion of ABH blood group substances is associated with Sickle Cell Anaemia.

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