Association between inflammation in acute phase and early onset pneumonia in patients with out‐of‐hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation

Shiba, Daiki; Hifumi, Toru; Watanabe, Yu; Shimizu, Masato; Isokawa, Shutaro; Toya, Nozomi; Iwasaki, Tadaaki; Otani, Norio; Ishimatsu, Shinichi

doi:10.1002/ams2.610

Cited by 5 publications

(4 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Shiba et al examined the EOP (hospitalization period of >48 h and within 7 days of admission) in OHCA patients treated with ECPR, and 20 of 55 (36.4%) patients developed EOP. 15 This was much higher than the result of the present study, i.e., 12.6%. However, they excluded patients who died within the first 48 h of admission; therefore, based on the hazard of death on the first 2 days in the present study, approximately half of the OHCA patients with ECPR were supposed to be excluded in this analysis.…”

Section: Discussioncontrasting

confidence: 70%

“…The clinical criteria were met when the patients showed at least one of three clinical features (i.e., fever ≥ 38.0 °C, leukocytosis [>12,000 cells/μL], and purulent tracheobronchial secretions). 15 , 16 The radiologic criteria were met by the presence of a new or progressive and persistent infiltrate characteristic of bacterial pneumonia or the presence of a new consolidation on chest X-ray imaging. The microbiologic criteria were met by a positive respiratory culture that did not contain normal bacterial flora.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Frequency, clinical characteristics, and outcomes of pneumonia in patients with out-of-hospital cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation

Iida,

Ichihara,

Hifumi

et al. 2023

Resuscitation Plus

Self Cite

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Frequency, clinical characteristics, and outcomes of pneumonia in patients with out-of-hospital cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation

Iida,

Ichihara,

Hifumi

et al. 2023

Resuscitation Plus

Self Cite

View full text Add to dashboard Cite

“…As a component of the body's reactions to infectious inflammation, changes in metabolism are pathological, leading to irreversible damage to cellular structures and disruption of individual organs and systems [4]. In this case, biochemical markers of inflammation and functional status of organs, in particular the liver, often precede morphological changes in tissues and organs, so they can be considered as early criteria for the development of the pathological process in various diseases [5].…”

Section: Introduction Pneumonia Remains the Leading Cause Of Infant Mortality And Morbiditymentioning

confidence: 99%

Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Dudnyk

Pasik

2021

J Educ Health Sport

View full text Add to dashboard Cite

Markers of infectious-inflammatory process were studied by determining the levels of pro-inflammatory cytokines - interleukin (IL) 1 and IL-6 and proteins of the acute phase of inflammation - C-reactive protein (CRP) and fibrinogen in the serum of children with community-acquired pneumonia. It was found that the course of community-acquired pneumonia is accompanied by an increase in serum concentrations of IL-1 and IL-6 in children in parallel with the disease severity. The synthesis of pro-inflammatory cytokines stimulates the production of acute CRP, but reduces the concentration of fibrinogen in the serum of sick children. The revealed connections between the content of the studied cytokines at the systemic level and multidirectional changes in the indicators of the acute phase of inflammation indicate a violation of the liver, where proteins are synthesized in the study. It is shown that with increasing severity of pneumonia, the enzyme activity of aminotransferases - alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum of children increases with a simultaneous decrease in the de Ritis coefficient, indicating "hepatic" genesis. High levels of aminotransferase is closely correlated with the activity of the infectious-inflammatory process, as indicated by the positive correlation between the level of IL-1 and ALT (r = 0.047) and AST (r = 0.111). At the same time, there is a negative correlation between the levels of IL-1, CRP and the activity of aminotransferases in blood serum.

show abstract

“…śƍžƍƑƂ ƋƄƅź-žƈżƈƘ ƊſźƄƐƟƃ ƈƊŽźƇƟƁƆƍ Ƈź ƟƇƎſƄƐƟƃƇſ ƁźƉź-ƅſƇƇƙ, ƁƆƟƇƂ ƆſƌźŻƈƅƟƁƆƍ ƆźƘƌƖ ƉźƌƈƅƈŽƟƑƇƂƃ ƏźƊźƄƌſƊ, ƉƊƂƁżƈžƙƑƂ žƈ ƇſƉƈƉƊźżƇƂƏ ƉƈƒƄƈ-žƀſƇƖ ƄƅƟƌƂƇƇƂƏ ƋƌƊƍƄƌƍƊ Ɵ ƉƈƊƍƒſƇƇƙ ƊƈŻƈƌƂ ƈƄƊſƆƂƏ ƈƊŽźƇƟż ƌź ƋƂƋƌſƆ [8]. ũƊƂ ƐƖƈƆƍ ŻƟƈ-ƏƟƆƟƑƇƟ ƆźƊƄſƊƂ ƁźƉźƅſƇƇƙ ƌź ƎƍƇƄƐƟƈƇźƅƖƇƈŽƈ ƋƌźƇƍ ƈƊŽźƇƟż, ƁƈƄƊſƆź ƉſƑƟƇƄƂ, ƇſƊƟžƄƈ żƂƉſ-ƊſžƀźƘƌƖ ƆƈƊƎƈƅƈŽƟƑƇƟ ƁƆƟƇƂ ż ƌƄźƇƂƇźƏ Ɵ ƈƊŽź-ƇźƏ, ƌƈƆƍ ƆƈƀƍƌƖ ƊƈƁŽƅƙžźƌƂƋƙ ƙƄ ƊźƇƇƟ ƄƊƂƌſ-ƊƟƠ ƊƈƁżƂƌƄƍ ƉźƌƈƅƈŽƟƑƇƈŽƈ ƉƊƈƐſƋƍ ƉƊƂ ƊƟƁƇƂƏ ƁźƏżƈƊƘżźƇƇƙƏ [19].…”

Section: ŝƌƌƍɖ ũunclassified

Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Dudnyk¹,

Pasik²

2022

MPU

View full text Add to dashboard Cite

Today, pneumonia remains the leading cause of infant mortality and morbidity worldwide. Pneumonia increases inflammatory processes, accompanied by the activation of inflammatory mediators, and can provoke significant metabolic disorders in the body. Purpose - to determine liver dysfunction in young children with community-acquired pneumonia based on the study of markers of infectious-inflammatory process. Materials and methods. The results of clinical and laboratory examination of 338 children aged 1 month to 3 years with community-acquired pneumonia were analyzed. The children were hospitalized in the Infectious Diseases Boxed Department for Young Children of the Vinnytsia Regional Children’s Clinical Hospital. Verification of the diagnosis was made using the recommendations of the British Thoracic Society. All patients had pneumonia of varying severity, depending on which they were divided into two groups: group I - 129 children who were diagnosed with community-acquired pneumonia of moderate severity; group II - 209 patients with severe pneumonia. Comparison group - 40 healthy children. Results. Markers of infectious-inflammatory process were studied to determine the levels of pro-inflammatory cytokines - interleukin (IL-1, IL-6) and proteins of the acute phase of inflammation - C-reactive protein (CRP) and fibrinogen in the serum of young children with outpatients. Aminotransferase hyperenzymemia is closely correlated with the activity of the infectious-inflammatory process, which indicates a positive correlation between the level of IL-1 and ALT (rxy=+0.047) and AST (rxy=+0.111). At the same time, there is a negative correlation between the levels of IL-1, CRP and the activity of aminotransferases in blood plasma. Conclusions. It was found that the course of community-acquired pneumonia is accompanied by an increase in the serum of children with concentrations of IL-1 and IL-6 in parallel with the severity of the disease. The synthesis of pro-inflammatory cytokines stimulates the production of acute CRP, but reduces the concentration of fibrinogen in the blood of sick children. The identified links between the content of the studied cytokines at the systemic level and multidirectional changes in the acute phase of inflammation indicate a violation of the liver, where proteins are synthesized. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: cytokines, C-reactive protein, fibrinogen, alanine aminotransferase, aspartate aminotransferase, liver, community-acquired pneumonia, children, early age.

show abstract

Association between inflammation in acute phase and early onset pneumonia in patients with out‐of‐hospital cardiac arrest treated with extracorporeal cardiopulmonary resuscitation

Abstract: Histogram of patients diagnosed as early onset pneumonia.

Cited by 5 publications

References 26 publications

Frequency, clinical characteristics, and outcomes of pneumonia in patients with out-of-hospital cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation

Frequency, clinical characteristics, and outcomes of pneumonia in patients with out-of-hospital cardiac arrest undergoing extracorporeal cardiopulmonary resuscitation

Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Contact Info

Product

Resources

About