Association between inflammatory biomarkers and all-cause, cardiovascular and cancer-related mortality

Singh‐Manoux, Archana; Shipley, Martin J.; Bell, Joshua A.; Canonico, Marianne; Elbaz, Alexis; Kivimäki, Mika

doi:10.1503/cmaj.160313

Cited by 77 publications

(52 citation statements)

References 25 publications

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“…The association between CRP plasma concentration and survival is well established in CV diseases . Elevated plasma CRP is also associated with increased mortality in patients with type II diabetes, cancer and also in the general population . Our results are consistent with previous studies, which reported an increased mortality in patients with elevated plasma CRP and low BMI …”

Section: Discussionsupporting

confidence: 94%

ADMA and NT pro‐BNP are associated with overall mortality in elderly

Rezaei

Weisshaar

Litschauer

et al. 2018

Eur J Clin Investigation

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Background Increased asymmetrical dimethylarginine ( ADMA ) and NT pro‐ BNP concentrations have been associated with mortality in patients with cardiovascular ( CV ) disease and the general population. The use of these prognostic markers in an older population is not established yet. The aim of the present study was to investigate the prognostic value of age, sex, BMI , co‐medication and CV laboratory risk markers in geriatric care patients. Materials and methods In this prospective observational single‐centre cohort study data of long‐term geriatric care patients were collected. Blood samples were collected between 14.09.2009 and 16.12.2009, and mortality was recorded up to 90 months. ADMA , its symmetric isomer SDMA , L‐arginine, NT pro‐ BNP and CRP were determined at study entry. Simple associations of risk factors for survival period were explored by Spearman correlation coefficient. Significant univariate predictors for survival period were used in the Cox proportional hazard model. Results A total of 481 patients were screened, and data from 449 patients were analysed. A total of 381 patients died during the observation period. Full data sets from 344 patients were used for Cox regression analysis. Male sex, older age, lower BMI , use of neuroleptic medicine, peripheral artery disease, and elevated plasma concentrations of ADMA , NT pro‐ BNP , and CRP were significant predictors of mortality. Conclusion The concentration of ADMA and NT pro‐ BNP may be used as an early risk marker for overall mortality in geriatric care. Neuroleptic medicine is associated with increased mortality in this population.

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Section: Discussionsupporting

confidence: 94%

ADMA and NT pro‐BNP are associated with overall mortality in elderly

Rezaei

Weisshaar

Litschauer

et al. 2018

Eur J Clin Investigation

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“…7 The recent Whitehall II study suggests that IL-6 and hsCRP are more important predictors of mortality than alpha-1-acid glycoprotein for cardiovascular, cancer and all-causes-related mortality. 14…”

Section: Introductionmentioning

confidence: 99%

Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort

Maluf

Barreto

Giatti

et al. 2020

J Epidemiol Community Health

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BackgroundHigh-sensitivity C reactive protein (hsCRP) has been proposed as a marker of incident cardiovascular disease and vascular mortality, and may also be a marker of non-vascular mortality. However, most evidence comes from either North American or European cohorts. The present proposal aims to investigate the association of hsCRP with the risk of all-cause mortality in a multiethnic Brazilian population.MethodsBaseline data (2008–2010) of a cohort of 14 238 subjects participating in the Brazilian Longitudinal Study of Adult Health were used. hsCRP was assayed with immunochemistry. The association of baseline covariates with all-cause mortality was calculated by Cox regression for univariate model and adjusted for different confounders after a mean follow-up of 8.0±1.1 years. The final model was adjusted for age, sex, self-rated race/ethnicity, schooling, health behaviours and prevalent chronic disease.ResultsThe risk of death increased steadily by quartiles of hsCRP, from 1.45 (95% CI 1.05 to 2.01) in quartile 2 to 1.95 (95% CI 1.42 to 2.69) in quartile 4, compared with quartile 1. Furthermore, the persistence of a significant graded association after the exclusion of deaths in the first year of follow-up suggests that these results are unlikely to be due to reverse causality. Finally, the HR was unaffected by the exclusion of participants who had self-reported medical history of diabetes, cancer and chronic obstructive pulmonary disease.ConclusionsOur study shows that hsCRP level is associated with mortality in a highly admixed population, independent of a large set of lifestyle and clinical variables.

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“…So far, only a few studies have investigated APPs in cats with cardiac disease 26,29,30 . In humans and dogs, several APPs have been associated with heart failure 31‐38 . The relationship between APPs and CHF in cats, however, is unclear.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy

Liu

Köster

Fosgate

et al. 2020

Veterinary Internal Medicne

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Background: Currently, the pathogenesis of congestive heart failure (CHF) in cats is not fully understood.Objective: To identify novel biomarkers for CHF in cats caused by primary cardiomyopathy, particularly related to cardiovascular-renal axis disorder and systemic inflammatory response.Animals: Twenty-five cats in CHF caused by primary cardiomyopathy, 12 cats with preclinical cardiomyopathy, and 20 healthy controls.Methods: Case control and observational case series. The following serum biomarkers were compared among the 3 cat groups: a cardiorenal profile that included N-terminal pro-brain natriuretic peptide (NT-proBNP), symmetric dimethylarginine (SDMA), and creatinine and an inflammatory profile that included 7 acute-phase proteins (APPs).Survival analyses and longitudinal studies were performed in CHF cats.Results: All cardiorenal biomarkers were positively correlated and higher in CHF cats, and high NT-proBNP and SDMA were associated with poor clinical outcome. Cats with CHF had significantly higher leucine-rich alpha-2-glycoprotein 1, serum amyloid A, and International Small Animal Cardiac Health Council; IVSd, interventricular septum thickness at end diastole; LA, left atrial; LA/Ao, left atrial-to-aortic root ratio; LRG1, leucine-rich alpha-2-glycoprotein 1; LV FS, left ventricular fractional shortening; LVFWd, left ventricular free wall thickness at end diastole; NT-proBNP, N-terminal pro-brain natriuretic peptide; PCT, procalcitonin; PE, point estimate; RCM, restrictive cardiomyopathy; ROC, receiver operating characteristic; SAA, serum amyloid A; SDMA, symmetric dimethylarginine; SEC, spontaneous echocardiographic contrast; SPARCL, spatial proximity analyte reagent capture luminescence; UCM, unclassified cardiomyopathy.

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Association between inflammatory biomarkers and all-cause, cardiovascular and cancer-related mortality

Cited by 77 publications

References 25 publications

ADMA and NT pro‐BNP are associated with overall mortality in elderly

ADMA and NT pro‐BNP are associated with overall mortality in elderly

Association between C reactive protein and all-cause mortality in the ELSA-Brasil cohort

Cardiovascular‐renal axis disorder and acute‐phase proteins in cats with congestive heart failure caused by primary cardiomyopathy

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