Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Labarca, Gonzalo; Drake, Lauren; Horta, Gloria; Jantz, Michael A.; Mehta, Hiren J.; Fernández-Bussy, Sebastián; Folch, Erik; Majid, Adnan; Picco, M.F.

doi:10.1186/s12890-019-0963-y

Cited by 30 publications

(27 citation statements)

References 39 publications

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“…Douglas et al [37] in their study found abnormal PFT in 32% of patients with UC, while Sethy et al [38] and Tzanakis et al [39] found abnormal PFT in 17 and 27% of patients with UC, respectively. Labarca et al [40] in their systemic review and meta-analysis found a relative risk (RR) of 2.02 for a new diagnosis of IBD in the COPD patients. This may be due to negative impact on colonic mucosae resulting in increased proinflammatory cytokines and angiogeneis factor.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Occult Pulmonary Involvement in Ulcerative Colitis

Gupta

Kothari

et al. 2020

Inflamm Intest Dis

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Introduction: Nearly 50% of patients with inflammatory bowel disease (IBD) experience at least one extraintestinal manifestation. Bronchopulmonary involvement is rare in IBD. Pulmonary function test (PFT) abnormality in cases of ulcerative colitis (UC) has been reported to be 17-55%. Occult pulmonary disease may be diagnosed using variables of the PFT. Hence, we aim to evaluate the frequency and type of pulmonary dysfunction in patients with UC in remission. Methods: Eighty-three patients of UC in remission and 48 controls underwent the PFT including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), and midexpiratory flow (MEF 25-75%) rate with a spirometer. The patients were divided based on the age of onset of UC into A1 (<16 years), A2 (16-40 years), and A3 (>40 years) and based on the extent of disease into E1 (proctitis), E2 (left-sided colitis), and E3 (extensive colitis). Results: Patients with UC had significantly abnormal PFT compared with controls (51 [61.5%] vss. 8 [16.67%]; p = 0.000). Patients with UC commonly had a restrictive pattern (33 [64.47%]) of PFT followed by small airway disease (11 [21.56%]) and obstructive pattern (7 [13.72%]). Pulmonary involvement in cases of UC was more in E3 followed by E2 and E1. Pulmonary involvement was more in the late age of onset of disease. BMI was positively and significantly correlated with FEV1 and FVC. Hemoglobin had a positive and significant correlation with FEV1 while a negative correlation with FEV1/FVC and MEF 25-75%. All predictors except for age were found to contribute in higher risk (OR > 1) for PFT abnormality. Conclusion: Patients with UC have chronic pulmonary inflammation leading to different patterns of lung involvement in the form of restrictive, obstructive airway, and small airway disease. Patients with UC commonly have a restrictive pattern of pulmonary involvement. Impairment of the PFT is related to the disease extent and the age of onset of disease. Assessment of the PFT using a spirometer is a noninvasive, simple, cost-effective, and reliable method for early detection of occult pulmonary involvement in patients of UC.

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Section: Discussionmentioning

confidence: 99%

Assessment of Occult Pulmonary Involvement in Ulcerative Colitis

Gupta

Kothari

et al. 2020

Inflamm Intest Dis

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“…South Korea has one of the highest incidence rates of IBD among all Asian countries [23,24,25,26]. Recent large-scale and scientifically robust studies regarding the aforementioned association, conducted in Asia, report findings comparable to regions with a high incidence of IBD such as Europe and Canada [7,16,27]. It is imperative to be up to date about the gastrointestinal symptoms suggestive of IBD in COPD patients.…”

Section: Biochemistry Of the Associationmentioning

confidence: 99%

“…Airway diseases are one of the most commonly studied manifestations of IBD [5]. Concurrently, the risk of new-onset IBD is found to be higher in populations with obstructive pulmonary diseases such as obstructive pulmonary disease (COPD), asthma, and bronchiectasis compared to the general population without these conditions [6,7,8]. This newly documented evidence of IBD incidence among patients with pulmonary diseases and the higher than the estimated prevalence of pulmonary conditions among IBD patients support the hypothesis of a two-way association [5].…”

Section: Introductionmentioning

confidence: 99%

“…There are many factors in common between IBDs and obstructive pulmonary diseases, including the complex multifactorial basis, the chronic remitting-relapsing course of the disease, and the low-grade systemic inflammation [5]. Both obstructive pulmonary diseases (asthma, COPD, bronchiectasis) and IBDs arise through intricate interactions between genetic and environmental factors [6,7]. The similarities in the pathogenesis of these diseases, genetic susceptibility, and common environmental risk factors suggest that there is a mutual association between IBD and obstructive pulmonary diseases [7].…”

Section: Introductionmentioning

confidence: 99%

“…Both obstructive pulmonary diseases (asthma, COPD, bronchiectasis) and IBDs arise through intricate interactions between genetic and environmental factors [6,7]. The similarities in the pathogenesis of these diseases, genetic susceptibility, and common environmental risk factors suggest that there is a mutual association between IBD and obstructive pulmonary diseases [7]. However, some literature also considers airway diseases merely as extraintestinal manifestations of IBD [5].…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Zergham

Sekhon

Mebasher

et al. 2020

Cureus

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Inflammatory bowel diseases (IBD) is an umbrella term that covers both ulcerative colitis (UC) and Crohn's disease (CD), which are chronic inflammatory conditions of the gastrointestinal system. Airway diseases are one of the most commonly studied manifestations of IBD. It is observed that populations with pre-existing obstructive pulmonary conditions are at higher risk of new-onset IBD. This newly documented evidence of increased incidence of IBD among patients with pulmonary diseases and the higher than the estimated prevalence of pulmonary diseases among IBD sufferers support the hypothesis of a two-way association. This review article focuses on summarizing the current knowledge and available evidence regarding the association between IBD and obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), emphysema, bronchiectasis, and asthma.We utilized PubMed as the primary search source and database and included the free full-text articles available on it, published over the past five years. We reviewed literature from multiple regions of the world, such as the US, UK, China, and Canada and compiled this traditional review article utilizing the information collected from 4,966,459 patients. Specifications such as age and gender were not mentioned in all articles. This review will serve to strengthen the existing research database concerning the relationship between IBD and obstructive pulmonary diseases. It will help to highlight the significance of the two-way association between IBD and obstructive pulmonary disease and the importance of treating these two conditions simultaneously. It will also raise awareness about the importance of timely detection of IBD and associated airway complications, leading to decreased disease burden and the treatment cost.

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Cryptotanshinone alleviates radiation‐induced lung fibrosis via modulation of gut microbiota and bile acid metabolism

Shen²,

Xin

et al. 2023

Phytotherapy Research

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Cryptotanshinone (CPT), a major biological active ingredient extracted from root of Salvia miltiorrhiza (Danshen), has shown several pharmacological activities. However, the effect of CPT on radiation‐induced lung fibrosis (RILF) is unknown. In this study, we explored the protective effects of CPT on RILF from gut‐lung axis angle, specifically focusing on the bile acid (BA)‐gut microbiota axis. We found that CPT could inhibit the process of epithelial mesenchymal transformation (EMT) and suppress inflammation to reduce the deposition of extracellular matrix in lung fibrosis in mice induced by radiation. In addition, 16S rDNA gene sequencing and BAs‐targeted metabolomics analysis demonstrated that CPT could improve the dysbiosis of gut microbiota and BA metabolites in RILF mice. CPT significantly enriched the proportion of the beneficial genera Enterorhabdus and Akkermansia, and depleted that of Erysipelatoclostridium, which were correlated with increased intestinal levels of several farnesoid X receptor (FXR) natural agonists, such as deoxycholic acid and lithocholic acid, activating the FXR pathway. Taken together, these results suggested that CPT can regulate radiation‐induced disruption of gut microbiota and BAs metabolism of mice, and reduce the radiation‐induced lung inflammation and fibrosis. Thus, CPT may be a promising drug candidate for treating RILF.

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Association between inflammatory bowel disease and chronic obstructive pulmonary disease: a systematic review and meta-analysis

Cited by 30 publications

References 39 publications

Assessment of Occult Pulmonary Involvement in Ulcerative Colitis

Assessment of Occult Pulmonary Involvement in Ulcerative Colitis

Inflammatory Bowel Disease and Obstructive Pulmonary Disease: A Two-way Association?

Cryptotanshinone alleviates radiation‐induced lung fibrosis via modulation of gut microbiota and bile acid metabolism

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