Association between inflammatory potential of diet and mortality among women in the Swedish Mammography Cohort

Shivappa, Nitin; Harris, Holly R.; Wolk, Alicja; Hébert, James R.

doi:10.1007/s00394-015-1005-z

Cited by 53 publications

(64 citation statements)

References 90 publications

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“…In line with our findings, in a cohort of US women, the DII was associated with all-cause, cancer, and CVD mortality (30). In another cohort including Swedish women, the DII was associated with all-cause and digestive tract cancer mortality (31). To our knowledge, no other prospective study has previously tested for the association between the DII and mortality, and none had tested this relation in men.…”

Section: Discussionsupporting

confidence: 71%

“…Although several studies have been published regarding the associations between the DII and incidence of chronic diseases (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29), only 2 studies, restricted to women, have investigated the relation between the pro-and anti-inflammatory potential of the diet measured with the DII and mortality (30,31), and none has studied how this association is modulated by antioxidant supplementation.…”

Section: Introductionmentioning

confidence: 99%

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Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial

Graffouillère

Deschasaux

Mariotti

et al. 2016

The American Journal of Clinical Nutrition

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Background: Chronic inflammation is a central mechanism involved in cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases, 4 leading causes of mortality. Diet is a major source of pro-and anti-inflammatory bioactive compounds. The Dietary Inflammatory Index (DII) was designed to estimate the overall inflammatory potential of the diet. Objective: Our aim was to study the prospective association between the DII and mortality, as well as assess whether antioxidant supplementation could modulate this association. Design: The Supplémentation en Vitamines et Minéraux Antioxydants study was a randomized, double-blind, placebocontrolled trial in which participants received low-dose antioxidants or a placebo from 1994 to 2002. In this observational prospective analysis, 8089 participants (mean 6 SD age at baseline: 49.0 6 6.3 y) were followed between 1994 and 2007 (median: 12.4 y). The DII was calculated from repeated 24-h dietary records; higher scores correspond to more proinflammatory diets. A total of 207 deaths occurred during follow-up, including 123 due to cancer and 41 due to cardiovascular events. Multivariate Cox proportional hazards models were computed. Results: Sex-specific tertiles of the DII were positively associated with cardiovascular + cancer mortality (HR for tertile 3 compared with tertile 1 = 1.53; 95% CI: 1.01, 2.32; P-trend = 0.05) and specific cancer mortality (HR for tertile 3 compared with tertile 1 = 1.83; 95% CI: 1.12, 2.99; P-trend = 0.02). The corresponding P value was 0.07 for all-cause mortality. The DII was statistically significantly associated with increased all-cause mortality in the placebo group (HR for tertile 3 compared with tertile 1 = 2.10; 95% CI: 1.15, 3.84; P-trend = 0.02) but not in the antioxidantsupplemented group (P-trend = 0.8; P-interaction = 0.098). Conclusion: These results suggest that a proinflammatory diet is associated with increased all-cause and cancer mortality and antioxidants may counteract some of the proinflammatory effects of the diet. This trial was registered at clinicaltrials.gov as NCT00272428.Am J Clin Nutr 2016;103:878-85.

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Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial

Graffouillère

Deschasaux

Mariotti

et al. 2016

The American Journal of Clinical Nutrition

Self Cite

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“…Table 3 shows five studies studying the association between the DII score and all-cause mortality [37,38,39,40,41]. In all studies except one, a higher risk of all-cause death was found among those participants with the highest pro-inflammatory values of the DII score.…”

Section: Mortality and The DII Scorementioning

confidence: 99%

“…Finally, the Swedish Mammography Cohort including a large sample size ( n = 33,747) found a direct association of the DII score with all-cause mortality as well as with CVD mortality (HR = 1.35; 95% CI: 1.01–1.81) when comparing extreme quintiles [41]. However, no significant association was found for cancer mortality or digestive-cancer mortality.…”

Section: Mortality and The DII Scorementioning

confidence: 99%

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Ruiz‐Canela

Bes–Rastrollo

Martínez‐González

2016

IJMS

146

102

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Inflammation is an underlying pathophysiological process in chronic diseases, such as obesity, type 2 diabetes mellitus and cardiovascular disease. In fact, a number of systematic reviews have shown the association between inflammatory biomarkers, such as CRP, IL-1β, IL-6, TNF-α, IL-4, or IL-10, and cardio-metabolic diseases. Diet is one of the main lifestyle-related factors which modulates the inflammatory process. Different individual foods and dietary patterns can have a beneficial health effect associated with their anti-inflammatory properties. The dietary inflammatory index (DII) was recently developed to estimate the inflammatory potential of overall diet. The aim of this review is to examine the findings of recent papers that have investigated the association between the DII, cardio-metabolic risk factors and cardiovascular disease. The relevance of the DII score in the association between inflammation and cardio-metabolic diseases is critically appraised, as well as its role in the context of healthy dietary patterns. We conclude that the DII score seems to be a useful tool to appraise the inflammatory capacity of the diet and to better understand the relationships between diet, inflammation, and cardio-metabolic diseases.

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“…For the updated version, several studies have found associations between DII score and CRP, in adults and seniors [26], and IL-6, tumour necrosis factor-alpha (TNF-α) and another score of combined inflammatory biomarker in postmenopausal women [27]. The DII score has been used in several studies to predict mortality [28,29], survival [30], and diseases, especially cancer [30,31], but also obesity [32], cardiovascular disease [33] and metabolic syndrome [32,34].…”

Section: Introductionmentioning

confidence: 99%

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

et al. 2017

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Background/objectives The dietary inflammatory index (DII) is a tool to measure the diet's inflammatory potential and has been used with adults to predict low-grade inflammation. The present study aims to assess whether this dietary score predicts low-grade inflammation in adolescents.Subjects/methods The sample comprises 329 adolescents (55.9% girls), aged 12-18 years, from LabMed Physical Activity Study. DII score was calculated based on a food-frequency questionnaire and categorized into tertiles. We collected blood samples to determine the follow inflammatory biomarkers: C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). In addition we calculated an overall inflammatory biomarker score. Odds ratios (OR) and 95% confidence intervals (95%CI) were computed from binary logistic regression models.Results DII score, comparing first with third tertile, was positively associated with IL-6 in crude model (OR = 1.88, 95% CI:1.09-3.24, p trend = 0.011) and in fully adjusted (for biological and lifestyle variables) (OR = 3.38, 95%CI:1.24-9.20, p trend = 0.023). Also, DII score was positively associated with C4, when fully adjusted (OR = 3.12, 95%CI:1.21-8.10, p trend = 0.016). DII score was negatively associated with C3 in crude model, comparing first with second but not with third tertile, and no significant associations in fully adjusted model were observed, although a trend was found (OR = 1.71, 95% CI:0.63-4.66, p trend = 0.044). No significant associations were observed between DII score and CRP. However, DII score was positively associated with the overall inflammatory biomarker score, when fully adjusted (OR = 5.61, 95% CI:2.00-15.78, p trend = 0.002).Conclusions DII score can be useful to assess the diet's inflammatory potential and its association with low-grade inflammation in adolescents.

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Association between inflammatory potential of diet and mortality among women in the Swedish Mammography Cohort

Abstract: These results indicate that a pro-inflammatory diet, as indicated by higher DII score, was associated with all-cause and digestive-tract cancer mortality.

Cited by 53 publications

References 90 publications

Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial

Prospective association between the Dietary Inflammatory Index and mortality: modulation by antioxidant supplementation in the SU.VI.MAX randomized controlled trial

The Role of Dietary Inflammatory Index in Cardiovascular Disease, Metabolic Syndrome and Mortality

Dietary inflammatory index and inflammatory biomarkers in adolescents from LabMed physical activity study

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