Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Abbood, Sattar Jabbar Abbood; Anvari, Enayat; Fateh, Abolfazl

doi:10.1186/s40246-023-00468-6

Cited by 16 publications

(11 citation statements)

References 30 publications

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“…Our data is the first to unravel the association between polymorphisms in IL-10 gene promoter and COVID-19 in an Egyptian population, which gives insight into the genetic diversity of immune responses towards SARS-COV2. We provided complementary evidence to the role of TNFa-308 polymorphism in a different Egyptian population [ 20 ] and were consistent with findings in Iranian population [ 50 ]. In conclusion, this study sheds light on the genetic determinants influencireatment response, and clinical outcomes in SARS-CoV-2 infection.…”

Section: Discussionsupporting

confidence: 88%

Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes

Eldesouki,

Kishk,

Abd El-Fadeal

et al. 2024

BMC Med Genomics

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Background Variation in host immune responses to SARS-CoV-2 is regulated by multiple genes involved in innate viral response and cytokine storm emergence like IL-10 and TNFa gene polymorphisms. We hypothesize that IL-10; -592 C > A and − 1082 A > G and TNFa-308 G > A are associated with the risk of SARS-COV2 infections and clinical outcome. Methods Genotyping, laboratory and radiological investigations were done to 110 COVID-19 patients and 110 healthy subjects, in Ismailia, Egypt. Results A significant association between the − 592 A allele, A containing genotypes under all models (p < 0.0001), and TNFa A allele with risk to infection was observed but not with the G allele of the − 1082. The − 592 /-1082 CG and the − 592 /-1082/ -308 CGG haplotypes showed higher odds in COVID-19 patients. Severe lung affection was negatively associated with − 592, while positive association was observed with − 1082. Higher D-dimer levels were strongly associated with the − 1082 GG genotype. Survival outcomes were strongly associated with the GA genotype of TNFa. -308 as well as AGG and AAA haplotypes. Conclusion IL-10 and TNFa polymorphisms should be considered for clinical and epidemiological evaluation of COVID-19 patients.

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Section: Discussionsupporting

confidence: 88%

Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes

Eldesouki,

Kishk,

Abd El-Fadeal

et al. 2024

BMC Med Genomics

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“…Concerning this issue, a previous study reported that polymorphisms in the IL10 gene are linked to the severity of the infected patients. This study found that IL10 gene polymorphisms rs1800871, rs1800872 and rs1800896 were linked to COVID-19 mortality in different SARS-CoV-2 variants in the Iranian population [41].…”

Section: Discussionmentioning

confidence: 66%

COVID-19: Focusing on the Link between Inflammation, Vitamin D, MAPK Pathway and Oxidative Stress Genetics

et al. 2023

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An uncontrolled inflammatory response during SARS-CoV-2 infection has been highlighted in several studies. This seems to be due to pro-inflammatory cytokines whose production could be regulated by vitamin D, ROS production or mitogen-activated protein kinase (MAPK). Several genetic studies are present in the literature concerning genetic influences on COVID-19 characteristics, but there are few data on oxidative stress, vitamin D, MAPK and inflammation-related factors, considering gender and age. Therefore, the aim of this study was to evaluate the role of single nucleotide polymorphisms in these pathways, clarifying their impact in affecting COVID-19-related clinical features. Genetic polymorphisms were evaluated through real-time PCR. We prospectively enrolled 160 individuals: 139 patients were positive for SARS-CoV-2 detection. We detected different genetic variants able to affect the symptoms and oxygenation. Furthermore, two sub-analyses were performed considering gender and age, showing a different impact of polymorphisms according to these characteristics. This is the first study highlighting a possible contribution of genetic variants of these pathways in affecting COVID-19 clinical features. This may be relevant in order to clarify the COVID-19 etiopathogenesis and to understand the possible genetic contribution for further SARS infections.

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“…There is evidence supporting the role of inflammation in the acute COVID-19 phase [ 4 , 5 ] and also in the post-COVID phase [ 20 ]. Thus, several polymorphisms associated with inflammation have been related to severe COVID-19 illness in previous studies [ 7 , 8 , 9 , 10 ]. Our study did not find an association between four SNPs associated with severe COVID-19, e.g., IL-6 rs1800796 , IL-10 rs1800896 , TNF-α rs1800629 , and IFITM3 rs12252 , and the presence of long-lasting post-COVID symptoms more than one year after infection.…”

Section: Discussionmentioning

confidence: 99%

“…Different polymorphisms can account for the variability in expression of these pro-inflammatory cytokines [ 6 ]. For instance, genotyping of cytokine-related single-nucleotide polymorphisms (SNPs), e.g., IL-6 rs1800796 [ 7 ], IL-10 rs1800896 [ 8 ], TNF-α rs1800629 [ 9 ], and IFITM3 rs12252 [ 10 ], has shown them to underlie the differential viral virulence and severity of COVID-19. Looking at the research, most studies have investigated the potential role of SNPs at the acute phase of SARS-CoV-2 infection, focusing on the risk of developing the severe form of the COVID-19 illness [ 6 , 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, genotyping of cytokine-related single-nucleotide polymorphisms (SNPs), e.g., IL-6 rs1800796 [ 7 ], IL-10 rs1800896 [ 8 ], TNF-α rs1800629 [ 9 ], and IFITM3 rs12252 [ 10 ], has shown them to underlie the differential viral virulence and severity of COVID-19. Looking at the research, most studies have investigated the potential role of SNPs at the acute phase of SARS-CoV-2 infection, focusing on the risk of developing the severe form of the COVID-19 illness [ 6 , 7 , 8 , 9 , 10 ]. Our understanding of the role of these SNPs in symptoms persisting after the acute phase of SARS-CoV-2 infection is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

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Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

Fernández-de-las-Peñas,

Díaz-Gil,

Gil-Crujera

et al. 2024

Viruses

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The aim of this study was to identify the association between four selected inflammatory polymorphisms with the development of long-term post-COVID symptoms in subjects who had been hospitalized due to SARS-CoV-2 infection during the first wave of the pandemic. These polymorphisms were selected as they are associated with severe COVID-19 disease and cytokine storm, so they could be important to prognoses post-COVID. A total of 408 (48.5% female, age: 58.5 ± 14.0 years) previously hospitalized COVID-19 survivors participated. The three potential genotypes of the following four single-nucleotide polymorphisms, IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252, were obtained from non-stimulated saliva samples of the participants. The participants were asked to self-report the presence of any post-COVID symptoms (defined as symptoms that had started no later than one month after SARS-CoV-2 acute infection) and whether the symptoms persisted at the time of the study. At the time of the study (mean: 15.6, SD: 5.6 months after discharge), 89.4% of patients reported at least one post-COVID symptom (mean number of symptoms: 3.0; SD: 1.7). Fatigue (69.3%), pain (40.9%), and memory loss (27.2%) were the most prevalent post-COVID symptoms in the total sample. Overall, no differences in the post-COVID symptoms depending on the IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252 genotypes were seen. The four SNPs assessed, albeit having been previously associated with inflammation and COVID-19 severity, did not cause a predisposition to the development of post-COVID symptoms in the previously hospitalized COVID-19 survivors.

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Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

Cited by 16 publications

References 30 publications

Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes

Association of IL-10–592 C > A /-1082 A > G and the TNFα -308 G > A with susceptibility to COVID-19 and clinical outcomes

COVID-19: Focusing on the Link between Inflammation, Vitamin D, MAPK Pathway and Oxidative Stress Genetics

Inflammatory Polymorphisms (IL-6 rs1800796, IL-10 rs1800896, TNF-α rs1800629, and IFITM3 rs12252) Are Not Associated with Post-COVID Symptoms in Previously Hospitalized COVID-19 Survivors

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