Association between interleukin-17 gene polymorphism and rheumatoid arthritis among Egyptians

Elfasakhany, Fathy M.; El-Damarawi, Magdi A.; Khalil, Ayman El-Sayed

doi:10.1016/j.mgene.2018.03.008

Cited by 15 publications

(11 citation statements)

References 39 publications

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“…In this study, the frequency of the Q allele was found to be 69 (69%) and 78 (78%), while that of the mutated R allele was 31(31%) and 22 (22%) in the patients and control group, respectively. This is in agreement with the frequency published by Hussein et al (2011) as well as Elfasakhany et al (2014).…”

Section: Discussionsupporting

confidence: 94%

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Darwish

Megahed

Attia

et al. 2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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All rights reserved. Introduction holinesterase inhibitor pesticides poisoning is a serious public health problem in Egypt because of their high morbidity and mortality in young adults. The organophosphorus and carbamates are the most popular cholinesterase inhibitor pesticides used as pest control in both the agricultural sector and residential use(Mansour, 2011). Acute exposure to carbamates and organophosphorus are clinically indistinguishable. Both of them inhibit cholinesterase enzyme activity leading to accumulation of acetylcholine which overstimulates nicotinic and muscarinic receptors. However, in carbamates the chemical bond is reversible leading to shorter duration of toxicity(Pope et al., 2005). There are multiple factors that lead to high susceptibility to poisoning by cholinesterase inhibitors pesticides. One of these factors is the interaction between genetic makeup of individuals and environmental exposurethat has been investigated in multiple studies. The role of the PON1 gene polymorphisms was always suspected due to previous animal knockout studies. They showed that high levels of PON1 protect individuals

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Section: Discussionsupporting

confidence: 94%

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Darwish

Megahed

Attia

et al. 2017

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…31 While in Egyptian and Polish populations, IL-17A genotypes were not associated with RA susceptibility. 4,32 Furthermore, in a study conducted among a Tunisian population, IL-17A polymorphisms did not show any significant association with RA prevalence. 33…”

Section: Discussionmentioning

confidence: 89%

Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

et al. 2021

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Objectives: Rheumatoid arthritis is a chronic inflammatory autoimmune disease. This study aimed to determine the association of interleukin-17A-197G/A polymorphism with rheumatoid arthritis in Sudanese patients. Methods: A case–control study was conducted between March and December 2018. Clinical and demographic data of the study participants were collected and analyzed. Polymerase chain reaction restriction fragment length polymorphism molecular technique was done to investigate interleukin-17A-197G/A polymorphisms. All statistical tests were considered statistically significant when p < 0.05. Results: The study population included 266 participants aged between 1 and 85 years, with an average of 40 years, classified into 85 (31.2%) cases (mean age 48.5 ± 11.3 years), and 181 (68.8%) controls (mean age 35.3 ± 15.9 years). The interleukin-17A homozygote AA genotype was more frequent among the control group compared to the case group; 95 (52.5%) and 7 (8.2%), respectively. The homozygote GG and the heterozygote AG genotypes were proportionally not different among the cases and control groups; 13 (54.2%) and 11 (45.8%), and 65 (46.4%) and 75 (53.6%), respectively. According to the distribution of interleukin-17A genotypes, a statistically significant difference was observed among cases with the interleukin-17A AA and AG genotypes, p values 0.001 and 0.004, respectively. For the association interleukin-17A genotypes and family history a negatively significant association was reported (95% confidence interval, –0.219, p value = 0.001). There was also a negatively significant association of interleukin-17A genotypes and anti-cyclic citrullinated peptide (95% confidence interval, −0.141, p value = 0.002). Conclusion: This study is the first study in Sudan established the association between interleukin-17A-197G/A (rs2275913) polymorphisms and susceptibly to rheumatoid arthritis. These findings appeal for further research in Sudan to investigate the exact role of IL-17A in immunopathology and disease severity among Sudanese rheumatoid arthritis

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“…Human PON1 protein comprises 355 amino acids and is encoded by 9 exons [7,8]. PON1 protein concentration and activity are affected by genetic polymorphisms [9]. There are numerous reports from various populations that demonstrate the correlation between PON1 gene polymorphisms and stroke [10,11].…”

Section: Resultsmentioning

confidence: 99%

Importance of Genetic Polymorphisms (Rs662 and Rs854560) of the Paraoxonase-1 Gene as Risk Factor for Acute Ischemic Stroke in Turkish Population

Antonio¹,

Alfredo²,

Luisa³

et al. 2019

Int J Crit Care Emerg Med

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Introduction: Ischemic stroke is account for most of the mortality and morbidity cases around the World. Paraoxonase-1 (PON1) is a significant candidate gene for ischemic stroke because of its function against atherosclerosis. Methods: We studied two common polymorphisms (Q192R [rs662] and L55M [rs854560]) of PON1 gene using PCR-based RFLP assay. Overall, 107 patients diagnosed as acute ischemic stroke and 99 healthy controls were enrolled in the present study. We also carried out a meta-analysis containing 3 case-control studies from Turkey. Results: Allele frequencies of PON1 gene Q192R and L55M polymorphisms didn't demonstrate any significant differences between patients and controls (p > 0.05). However, genotype frequencies were significantly different between patients and controls in terms of Q192R polymorphism (p = 0.030). Statistically significant correlations were observed between systolic and diastolic blood pressures of patients and L55M polymorphism (p = 0.017 and p = 0.039, respectively). Heterozygosity for the both Q192R and L55M polymorphisms demonstrated a statistically significant association with acute ischemic stroke in composite genotype analyses (p = 0.033). The results of meta-analysis showed a significant correlation between acute ischemic stroke and the PON1 gene L55M polymorphism in Turkish population. Conclusion: PON1 gene Q192R and L55M polymorphisms may have effects on acute ischemic stroke susceptibility in Turkish population.

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Association between interleukin-17 gene polymorphism and rheumatoid arthritis among Egyptians

Cited by 15 publications

References 39 publications

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Paraoxonase 1 gene polymorphism and enzymatic activity as a prognostic marker in cases of poisoning by cholinesterase inhibitor pesticides among Egyptians

Association of interleukin-17A rs2275913 polymorphism with rheumatoid arthritis susceptibility in Sudanese population

Importance of Genetic Polymorphisms (Rs662 and Rs854560) of the Paraoxonase-1 Gene as Risk Factor for Acute Ischemic Stroke in Turkish Population

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