Association between interleukin 17A gene polymorphisms and risk of coronary artery disease

Xs, Zheng; S, Wang; Ni, Mingkang

doi:10.4238/gmr.15017074

Cited by 5 publications

(7 citation statements)

References 12 publications

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“…Among them, 57 studies were excluded for irrelevance, three were master’s degree theses, two for predicting IL-17A polymorphisms and ischemic stroke. Finally, six studies met the criteria, including 3542 cases and 3212 controls [ 7 , 8 , 9 , 10 , 11 , 17 ]. Among them, five studies described the associations between IL-17A rs2275913 and CAD, and three studies described the associations between IL-17A rs8193037 and CAD, two studies for each described association between rs3819025, rs3748067, rs3819024 and CAD, and one study for each described association between IL-17A rs4711998, rs8193036, and CAD.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, several SNPs in IL-17A have been studied to investigate their relations with CAD risk. rs2275913 has gained the greatest attention in these involved studies, some of which found a significant association between rs2275913 and CAD [ 7 , 8 ], while others denied it [ 9 , 10 , 11 ]. Our meta-analysis did not find any relations between rs2275913 and CAD in overall analysis, but lower risk of CAD was found in GG genotype in small sample size groups when subgroup analysis was conducted.…”

Section: Discussionmentioning

confidence: 99%

“…According to recent data, the AA and GA + AA genotype of rs2275913, CC, and TC + CC of rs3748067 are thought to be probably associated with the risk of CAD by some research [ 7 , 8 ]. However, the results were inconsistent and inconclusive [ 9 , 10 , 11 ]. Thus, in the present study, we included a total of six studies, with 3542 cases and 3212 controls, to get a more precise and comprehensive estimation of the association between these polymorphisms and CAD.…”

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease

Bao

Luo

et al. 2016

IJERPH

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Coronary artery disease (CAD) is a disease which has become a leading cause of death worldwide. The polymorphisms in Interleukin-17 (IL-17A), including rs2275913, rs3819024, rs3819025, rs3748067, rs8193037, rs4711998, and rs8193036, have been found to be probably associated with the risk of CAD. However, the results were inconsistent and inconclusive. The present study performed a meta-analysis to get a more precise and comprehensive estimation of the association between the IL-17A polymorphisms and CAD risk. The Pubmed, Embase, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, and Chinese Biomedical Literature Databases were searched for related studies. A total of six studies, including 3542 cases and 3212 controls, were identified for the meta-analysis. The main findings of the present meta-analysis show that the TT genotype of IL-17A rs3748067 is associated with a significant lower risk of CAD in the homozygous model odds ratio (OR) (OR = 0.37) in Asians. No significant association was found for rs2275913, rs3819024, rs3819025, rs8193037, rs4711998, and rs8193036 with CAD susceptibility in the overall analysis. However, subgroup analysis indicated a significant decreased risk of CAD for the GG genotype and G allele of rs2275913 in a small sample size group, and a higher risk of CAD for the GG genotype and G allele of rs8193037 in a heterozygous model (OR = 1.56), dominant model (OR = 1.54), and allelic model (OR = 1.47) in Asians. In conclusion, the current meta-analysis suggests a significant relationship between rs3748067, rs8193037, and CAD in Asians, while for rs2275913, rs3819024, rs3819025, rs4711998, rs8193036, no such relations were found. Thus, IL-17A rs3748067 and rs8193037 might be recommended as a predictor for susceptibility of CAD for Asians. However, the results of this meta-analysis are hypothesis-generating results which should be interpreted with caution because of the heterogeneity and publication bias among study designs.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease

Bao

Luo

et al. 2016

IJERPH

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“…IL-17A gene, which is located on chromosome 6p12.23 in human genome, encodes the IL-17A cytokine. Recently, several polymorphisms in the IL-17A gene were identified, among them, rs1974226 and rs3748067 polymorphisms in the 3’ untranslated region (3’ UTR) of the IL-17A gene, and rs2275913 polymorphism in the promoter of the IL-17A gene, which were reported to be functional in influencing individual’s susceptibility to a huge numbers of human diseases, such as gastric cancer [ 32 – 35 ], pulmonary tuberculosis [ 36 ], asthma [ 37 – 39 ], osteoarthritis [ 40 ], rheumatoid arthritis [ 41 ], and CAD [ 42 – 44 ]. However, to date, no study has been reported on the association between polymorphisms in the IL-17A gene and IS risk.…”

Section: Introductionmentioning

confidence: 99%

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

Huang

Wang

et al. 2017

Oncotarget

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The aim of our study was to investigate the association of interleukin-17A (IL-17A) polymorphisms with IL-17A serum levels and risk of ischemic stroke (IS) in a Chinese population. 392 IS patients and 443 controls were included in this study. The polymorphisms of IL-17A gene were determined by Snapshot SNP genotyping assay and DNA sequencing. Serum IL-17A levels were measured by enzyme-linked immunosorbent assay (ELISA). We found that the G allele, GA and GG genotypes, and GA/GG vs. AA model of rs2275913 polymorphism were associated with increased risk of IS even after adjusted by clinical characters such as age, gender and diabetes (G vs. A: OR=1.27, 95% CI, 1.05∼1.54, P=0.014; GA vs. AA: OR=1.72, 95% CI, 1.05∼2.81, P=0.032; GG vs. AA: OR=1.99, 95% CI, 1.08∼3.67, P=0.028; GA/GG vs. AA: OR=1.78, 95% CI, 1.11∼2.86, P=0.017). Serum IL-17A levels were increased in IS patients compared with controls (P<0.01). Individuals carrying rs2275913 GA or GG genotype present higher serum IL-17A levels compared with the rs2275913AA genotype in the IS group (P<0.01). In conclusion, this is the first study reporting the rs2275913 polymorphism as a risk factor for IS, which may be partly explained by influencing the levels of IL-17A cytokine.

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“…Previous studies have indicated that several inflammatory factors contribute to the development of CAD, such as C-reactive protein, tumor necrosis factor, interleukin-6 (IL-6), IL-17A, and transforming growth factor (Zernecke et al, 2008;Yang et al, 2015;Zheng et al, 2016). An association has also been reported between IL-18 and atherosclerotic plaque rupture (de Nooijer et al, 2004), which, in turn, is believed to influence the occurrence of CAD (Opstad et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population

Chen²,

Gao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Coronary artery disease (CAD) has a high mortality rate in several countries. Interleukin (IL)-18 has been previously correlated with atherosclerotic plaque rupture. In this case-control study, the relationship between -607A/C and -372C/G promoter polymorphisms in IL-18 and risk of CAD development was investigated. A total of 326 CAD patients were consecutively recruited from the First Hospital of Yulin between March 2013 and May 2015. The IL-18 -607A/C and -372C/G polymorphisms were genotyped by polymerase chain reactionrestriction fragment length polymorphism. Patients with CAD had a higher body mass index, a history of hypertension or diabetes (all P < 0.001), cigarette smoking habit (P = 0.002); as well as higher plasma total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels (all P < 0.001) and lower high-density lipoprotein cholesterol (P < 0.001) levels compared to the control subjects. Unconditional logistic regression analysis revealed significant correlation between the CC genotype of IL-18 -607A/C and CAD development, compared to the AA genotype [adjusted odds ratio (OR) = 2.42; 95% confidence interval (CI) = 1.52-3.89; P < 0.001]. The recessive model showed a significant association between the CC genotype of IL-18 -607A/C and an increased risk of CAD, compared to the AA+AC genotype (OR = 2.51, 95%CI = 1.65-3.85). However, IL-18 -372C/G did not contribute to the risk of glioma development in the co-dominant, dominant, and recessive models. Therefore, the IL-18 -607C/A polymorphism was significantly correlated with the risk of CAD development.

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Association between interleukin 17A gene polymorphisms and risk of coronary artery disease

Cited by 5 publications

References 12 publications

Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease

Meta-Analysis for the Association between Polymorphisms in Interleukin-17A and Risk of Coronary Artery Disease

The association of IL-17A polymorphisms with IL-17A serum levels and risk of ischemic stroke

Effect of polymorphisms in interleukin-18 gene on the susceptibility to coronary artery disease in a Chinese population

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