Association Between Interleukin 6 and C-Reactive Protein Serum Levels and Body Composition Compartments and Components in Breast Cancer Survivors

Abstract

Obesity is highly prevalent in breast cancer (BC) survivors. Adipose tissue promotes inflammation, affecting recurrence, morbidity, and quality of life. This study aimed to determine the relationship of body composition parameters with the levels of C-reactive protein (CRP) and interleukin 6 (IL-6) in female BC survivors. Additionally, we evaluated the association of log-transformed serum concentrations of CRP and IL-6 with the appendicular skeletal lean mass index (ASMI). The results showed that CRP was positively associated with body fat percentage (BFP; β adjusted = .08, 95% CI: .02–.14) in all participants, and with fat mass index (FMI; β = .24, 95% CI: .08–.40) only in premenopausal women. IL-6 was positively associated with FMI (β adjusted = .16, 95% CI: .03–.29), while ASMI decreased as CRP levels increased (β adjusted = −.30, 95% CI: −.53 to −.06). Interventions to improve body composition in BC survivors should also consider the role of inflammatory markers in changes in body composition to avoid sarcopenic obesity (SO) and the risk of BC recurrence.

Neuroinflammaging: A Tight Line Between Normal Aging and Age-Related Neurodegenerative Disorders

“…Several environmental factors can exacerbate the ageinduced neuroinflammatory responses, thus contributing to increased risk for neurodegenerative diseases in predisposed individuals, for instance by inducing epigenetic modifications or accelerating telomere shortening [154]. In this regard, according to genome wide association studies, several environmental agents like exposure to pesticides, metal, pollution, and diet seem to be pathogenically related to neurodegeneration [155,156].…”