Association between interleukin-8 gene −251 T/A polymorphism and the risk of peptic ulcer disease: A meta-analysis

Interleukin-8 in gastrointestinal inflammation and malignancy: induction and clinical consequences

“…Individuals with adenosine residues at position −251 (−251A) of the CXCL8 gene are thought to be at increased risk of infection from Clostridium difficile, enteroaggregative Esherichia coli, and H. pylori, and following infection, have elevated inflammatory responses and/or more clinically significant disease. [100][101][102][103][104][105][106][107][108][109] It is currently unknown whether these polymorphisms enhance susceptibility to other GI pathogens. Moreover, −251A polymorphisms are thought to increase susceptibility to the development of gastric cancer and IBD.…”

Volume 34 Number 3

“…Although rare in Australia, EBVassociated BL is endemic in regions of Africa and Papua New Guinea 22 . It arises primarily in young children and its incidence is closely associated with malaria endemic regions, which has been attributed to a loss of functionality in EBV-specific T cells in children with co-exposure to malaria 39,40 . Burkitt lymphoma cells typically display an EBV latency I profile, characterised by the expression of only EBNA1 (Table 1).…”

“…In a study conducted in France of children with known asthma and children with a new diagnosis of asthma, Biscardi et al found that M. pneumoniae and C. pneumoniae were found in both groups of children, but at higher infection rates in those children with newly diagnosed asthma (50% of newly diagnosed patients had M. pneumoniae infection compared with 5.2% of stable asthma patients). Along with the different bacteria, respiratory viruses were tested for within the participants; however, major comparisons were not made and coinfections were not looked at 40 . Further to this, of those children infected with both bacteria and who were experiencing their first attack, 62% had asthma recurrences compared with only 27% who were not infected 40 .…”

“…Along with the different bacteria, respiratory viruses were tested for within the participants; however, major comparisons were not made and coinfections were not looked at 40 . Further to this, of those children infected with both bacteria and who were experiencing their first attack, 62% had asthma recurrences compared with only 27% who were not infected 40 . …”

Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia

“…Продукция карбогидратных антигенов групп крови, антигена Lewis и других молекул адгезии, с кото-рыми взаимодействует H. pylori и другие бактерии, кон-тролируется генами, кодирующими структуру гликозил-трансфераз, что, по-видимому, вносит вклад в предрас-положенность к ЯБ [11]. Среди других генетических фак-торов, предрасполагающих к развитию ЯБ двенадцати-перстной кишки, описаны полиморфизм генов матрикс-ных металлопротеиназ-1, -3, -9 и тканевого ингибитора металлопротеиназ-3, носительство 607С-и -251 T/A-аллелей гена провоспалительного интерлейкина-8, поли-морфизм HLA (HLA-DQB1*0602, DQA1*0301), особенности строения молекул толл-подобных рецепторов-9 и -4, белка теплового шока 70-2 и некоторые другие [12][13][14][15].…”