Association Between Intermittent Hypoxia and Left Ventricular Remodeling in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome

Deng, Ming; Huang, Yiteng; Xu, Jin; Xiao, Ke; Yan, Dong; Cheng, Xiaoshu

doi:10.3389/fphys.2020.608347

Cited by 15 publications

(11 citation statements)

References 48 publications

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“…Using PWD,Chan et al, (2009) also observed a higher right ventricular MPI in children with moderate to severe OSAS (confirmed by PSG) than in those with mild OSAS and those without OSAS. Consistent to prior reports;Deng et al, 2021 also showed that the values of IVS and LVIDs were higher in patients with severe OSAHS than those without OSAHS or those with less severe OSAHS. Furthermore, they also observed that the LVM and LVMI-height were also significantly higher in patients with severe OSAHS.…”

supporting

confidence: 91%

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Impact of nocturnal hypoxia and hypercapnea on global myocardial performance in patients with sleep related breathing disorders

Shabana

Elshal

Elhadidy

et al. 2022

ijhs

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Background: Sleep related breathing disorders (SRBDs) are disorders caused by a decline or interruption in breathing during sleep and can be complicated by cardiovascular complications. Objective: The aim of this study was to evaluate the impact of chronic intermittent hypoxia and nocturnal hypercapnia on global myocardial performance utilizing different modes of echocardiography in patients with SRBDs. Methods: This a case control study was conducted on 142 adult subjects who attended to outpatient clinics and Mansoura university sleep center, Egypt during the period study from august 2016 till august 2018. Results: There were statistically significant higher BMI and NC in patients with OSA, OHS groups versus the control group (p<0.001). Comparing OSA& OHS groups with control group, statistically significant difference regarding each of MPI, GLS, TAPSE (mm) and grade of DD by TDI (p<0.05), GLS, TAPSE (mm) and grade of DD by TDI respectively. Speckle tracking echocardiography showed statistically significant differences all over the 17 segment of the LV and the most affected segments are Inferolateral, Inferior and Inferoseptal and showed that basal segments more affected than mid and apical segments.Conclusion: there is cardiovascular comorbidity associated with chronic intermittent hypoxia and nocturnal hypercapnia in patients with OSA and OHS.

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supporting

confidence: 91%

“…These findings strongly indicate that presence of OSAHS is significantly associated with LV remodeling. Moreover,Deng et al, 2021 also found that severe OSAS patients had slight LVH.…”

mentioning

confidence: 92%

Impact of nocturnal hypoxia and hypercapnea on global myocardial performance in patients with sleep related breathing disorders

Shabana

Elshal

Elhadidy

et al. 2022

ijhs

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“…Our results indicate that free-fed ob/ob mice exposed to acute IH exhibit cardiac changes present with OSA, namely an increase in LV mass, interventricular septum thickness, and LV dilation (Yu et al, 2020;Deng et al, 2021). OSA increases one's risk for both concentric and eccentric cardiac hypertrophy (Cuspidi et al, 2020).…”

Section: Discussionmentioning

confidence: 73%

Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice

et al. 2022

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Background: Intermittent hypoxia (IH), a key characteristic of obstructive sleep apnea, is independently associated with cardiometabolic impairment. While endogenous leptin levels may provide cardioprotective effects against hypoxia, leptin resistance is common among obese individuals presenting with obstructive sleep apnea.Methods: Here, we assessed left ventricle (LV) function using M-mode echocardiography in lean wild-type, calorically-restricted ob/ob, and obese ob/ob mice before and after 6 days of IH to determine how obesity and intermittent hypoxia interact to affect cardiac function independent of leptin signaling.Results: Calorically-restricting ob/ob mice for 4 weeks prior to IH exposure prevented weight gain (−2.1 ± 1.4 g) compared to free-fed ob/ob mice (8.7 ± 1.1 g). Free-fed ob/ob mice exhibited increased LV mass (0.713 ± 0.008 g) relative to wild-type mice (0.685 ± 0.004 g) and increased posterior wall thickness (0.089 ± 0.006 cm) relative to calorically-restricted ob/ob mice (0.072 ± 0.004 cm). Following 6 days of IH, free-fed ob/ob mice exhibited increases in cardiac output (44.81 ± 2.97 pre-IH vs. 57.14 ± 3.09 ml/min post-IH), LV diameter (0.400 ± 0.007 pre-IH vs. 0.428 ± 0.009 cm post-IH) and end diastolic volume (0.160 ± 0.007 pre-IH vs. 0.195 ± 0.012 ml post-IH) that were not detected in wild-type or calorically-restricted ob/ob mice.Conclusion: Caloric restriction can prevent obesity-induced LV hypertrophy and protect against acute IH-induced cardiac remodeling independent of leptin signaling. These findings may have clinical implications for obstructive sleep apnea.

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“…Deng et al 18 from China, concluded that male gender, high body mass index, systolic and diastolic blood pressure and use of antihypertensive drugs were associated with compromised left ventricular function. We generated similar results as our data also showed that comorbid Type-2 DM, Hypertension and high BMI had a statistically significant relationship with left ventricular systolic dysfunction among patients suffering from sleep apnea syndrome.…”

Section: Discussionmentioning

confidence: 99%

Left Ventricular Systolic Dysfunction in Patients of Obstructive Sleep Apnea Syndrome

Sukhera

Mirza²,

Azam³

et al. 2023

PAFMJ

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Objective: To determine the left ventricular systolic dysfunction and the association of various factors with this dysfunction in patients with obstructive sleep apnea syndrome. Study Design: Cross-sectional study. Place and Duration of Study: Pak Emirates Military Hospital, Rawalpindi Pakistan, from Dec 2020 to May 2021. Methodology: We included the patients diagnosed with sleep apnea syndrome by a consultant pulmonologist based on a sleep study. Patients were labelled as having left ventricular systolic dysfunction if the ejection fraction was less than 40% on echocardiography. Results: Eighty patients diagnosed with sleep apnea syndrome were included in the study. The mean age of the study participants was 48.551±9.971 years. Out of 80 patients, 19(23.75%) had left ventricular systolic dysfunction on echocardiography, while 61(76.25%) had no evidence of left ventricular systolic dysfunction. With the application of relevant statistical tests, we found that patients with high body mass index and the presence of comorbid illnesses had a statistically significant relationship (p-value<0.05) with the presence of left ventricular systolic dysfunction among patients with sleep apnea syndrome. Conclusion: Considerable number of patients suffering from obstructive sleep apnea syndrome showed the presence of left ventricular systolic dysfunction on echocardiography. High Body mass index and comorbid illnesses emerged as risk factors for left ventricular systolic dysfunction in our study population.

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Association Between Intermittent Hypoxia and Left Ventricular Remodeling in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome

Cited by 15 publications

References 48 publications

Impact of nocturnal hypoxia and hypercapnea on global myocardial performance in patients with sleep related breathing disorders

Impact of nocturnal hypoxia and hypercapnea on global myocardial performance in patients with sleep related breathing disorders

Caloric restriction prevents obesity- and intermittent hypoxia-induced cardiac remodeling in leptin-deficient ob/ob mice

Left Ventricular Systolic Dysfunction in Patients of Obstructive Sleep Apnea Syndrome

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