Association between intestinal microbiome and inflammatory bowel disease: Insights from bibliometric analysis

Peng-fei, XU; Lv, Tengteng; Dong, Shenghui; Cui, Zhihao; Luo, Xiangfeng; Jia, Baolei; Jeon, Che Ok; Zhang, Jie

doi:10.1016/j.csbj.2022.04.006

Cited by 24 publications

(13 citation statements)

References 83 publications

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“…Cluster analysis is a statistical method for dividing the subjects of a particular field into several groups, which can reflect the research focus in the field ( van Eck and Waltman, 2010 ; Xu et al, 2022 ). Our clustering analysis of keywords identified five focus areas of the research in gastrointestinal microbiome and neuroscience utilizing VOSviewer.…”

Section: Discussionmentioning

confidence: 99%

“…This approach, which has been used in a variety of domestic and international fields, offers a diverse perspective that traditional literature reviews and systematic reviews cannot ( Chen et al, 2014 ; Cesarano et al, 2021 ; Ma S. et al, 2021 ; Pan et al, 2021 ; Pasin and Pasin, 2021 ; Shi et al, 2021 ; Wu et al, 2021a ; Fu et al, 2022 ). Bibliometric analysis has been widely used in the field of microbial science, such as microbiome and COVID-19 ( Xavier-Santos et al, 2022 ), gut microbiota and host immune response ( Ni et al, 2022 ), gut microbiota and atherosclerosis ( Wang Y. et al, 2022 ), microbiome-gut-brain axis ( Wang H. et al, 2022 ), gut microbiota and heart failure ( Mu et al, 2022 ), gut microbiome and cancer ( Zyoud et al, 2022 ), the intestinal microbiome and inflammatory bowel disease ( Xu et al, 2022 ), gut microbiota and Parkinson’s disease ( Cabanillas-Lazo et al, 2022 ), and gut microbiota and depression ( Zhu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

et al. 2022

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BackgroundScholars have long understood that gastrointestinal microorganisms are intimately related to human disorders. The literature on research involving the gut microbiome and neuroscience is emerging. This study exposed the connections between gut microbiota and neuroscience methodically and intuitively using bibliometrics and visualization. This study’s objectives were to summarize the knowledge structure and identify emerging trends and potential hotspots in this field.Materials and methodsOn October 18, 2022, a literature search was conducted utilizing the Web of Science Core Collection (WoSCC) database for studies on gut microbiota and neuroscience studies from 2002 to 2022 (August 20, 2022). VOSviewer and CiteSpace V software was used to conduct the bibliometrics and visualization analysis.ResultsFrom 2002 to 2022 (August 20, 2022), 2,275 publications in the WoSCC database satisfied the criteria. The annual volume of publications has rapidly emerged in recent years (2016–2022). The most productive nation (n = 732, 32.18%) and the hub of inter-country cooperation (links: 38) were the United States. University College Cork had the most research papers published in this area, followed by McMaster University and Harvard Medical School. Cryan JF, Dinan TG, and Clarke G were key researchers with considerable academic influence. The journals with the most publications are “Neurogastroenterology and Motility” and “Brain Behavior and Immunity.” The most cited article and co-cited reference was Cryan JF’s 2012 article on the impact of gut microbiota on the brain and behavior. The current research hotspot includes gastrointestinal microbiome, inflammation, gut-brain axis, Parkinson’s disease (PD), and Alzheimer’s disease (AD). The research focus would be on the “gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition” and “the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases.” Burst detection analysis showed that schizophrenia, pathology, and psychiatric disorder may continue to be the research frontiers.ConclusionResearch on “gastrointestinal microbiome, inflammation: a link between obesity, insulin resistance, and cognition” and “the role of two important theories of the gut-brain axis and microbial-gut-brain axis in diseases” will continue to be the hotspot. Schizophrenia and psychiatric disorder will be the key research diseases in the field of gut microbiota and neuroscience, and pathology is the key research content, which is worthy of scholars’ attention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

et al. 2022

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“…The systematic and holistic literature review will help better understand the current research situation and select research directions. Bibliometrics is an efficient method for analyzing the development trend, research progress, hotspots, discipline knowledge structure and its dynamic evolution relationship in a field by quantitatively analyzing literature materials through mathematical and statistical methods (7,8). So far, bibliometric analyses have not been seen in the field of GM in RA.…”

Section: Introductionmentioning

confidence: 99%

Relationship between gut microbiota and rheumatoid arthritis: A bibliometric analysis

Dong

Yao²,

Deng³

et al. 2023

Front. Immunol.

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IntroductionRheumatoid arthritis (RA) is a multifactorial autoimmune disease. Recently, growing evidence demonstrates that gut microbiota (GM) plays an important role in RA. But so far, no bibliometric studies pertaining to GM in RA have ever been published. This study attempts to depict the knowledge framework in this field from a holistic and systematic perspective based on the bibliometric analysis.MethodsLiterature related to the involvement of GM in RA was searched and picked from the Web of Science Core Collection (WOSCC) database. The annual output, cooperation, hotspots, research status and development trend of this field were analyzed by bibliometric software (VOSviewer and Bibliometricx).Results255 original research articles and 204 reviews were included in the analysis. The articles in this field that can be retrieved in WOSCC were first published in 2004 and increased year by year since then. 2013 is a growth explosion point. China and the United States are the countries with the most contributions, and Harvard University is the affiliation with the most output. Frontiers in Immunology (total citations = 603) is the journal with the most publications and the fastest growth rate. eLife is the journal with the most citations (total citations = 1248). Scher, Jose U. and Taneja, Veena are the most productive and cited authors. The research in this field is mainly distributed in the evidence, mechanism and practical application of GM participating in RA through the analysis of keywords and documents. There is sufficient evidence to prove the close relationship between GM and RA, which lays the foundation for this field. This extended two colorful and tender branches of mechanism research and application exploration, which have made some achievements but still have broad exploration space. Recently, the keywords ”metabolites“, ”metabolomics“, ”acid“, ”b cells“, ”balance“, ”treg cells“, ”probiotic supplementation“ appeared most frequently, which tells us that research on the mechanism of GM participating in RA and exploration of its application are the hotspots in recent years.DiscussionTaken together, these results provide a data-based and objective introduction to the GM participating in RA, giving readers a valuable reference to help guide future research.

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“…Since bibliometrics involves the use of statistics to analyze published information (such as journal articles) and its associated metadata (such as titles, abstracts, and author keywords), it facilitates a greater understanding of what is valued, acknowledged, and utilized in scholarly literature in a particular field ( Broadus, 1987 ; Albert et al, 2020 ). In the field of gastroenterology, several gastrointestinal diseases, including chronic atrophic gastritis ( Zhang et al, 2022c ), inflammatory bowel disease ( Connelly et al, 2016 ; Schöffel et al, 2016 , 2021 ; Azer and Azer, 2018 ; Luo et al, 2018 ; Chen et al, 2019 ; Chong et al, 2020 ; Li K. et al, 2022 ; Shen et al, 2022 ; Xiong et al, 2022 ; Xu et al, 2022 ), celiac disease ( Narotsky et al, 2012 ; Demir and Comba, 2020 ), irritable bowel syndrome (IBS) ( Zyoud et al, 2021 ; Zhang T. et al, 2022b ), and gastrointestinal stromal tumors ( Siddiq et al, 2018 ) have used bibliometrics to draw boundaries around their fields. Based on these parameters, journals, topics, members, and trends of the field have been described.…”

Section: Introductionmentioning

confidence: 99%

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

Zhang

et al. 2023

Front. Neurosci.

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ObjectivesThis study aims to perform a bibliometric analysis of functional dyspepsia (FD), which includes visualizing bibliographic information, in order to identify prevailing study themes, topics of interest, contributing journals, countries, institutions, and authors as well as co-citation patterns.MethodsThe Web of Science™ Core Collection Database was used to retrieve all peer-reviewed scientific publications related to FD research. The validated search terms were entered into the “title” and “author keywords” fields, and the results were sorted by publication year from 2006 to 2022. There were no restrictions on language. On 12 February 2023, a manual export of the complete metadata for each original publication and review article was performed. CiteSpace was used to reveal co-authorship, publication, and co-citation patterns to find prominent authors, organizations, countries, and journals in FD research as well as to identify author keywords with strong citation bursts, which could indicate an emerging research area. VOSviewer was used to build the co-occurrence indicator (co-word) to identify the main author keywords on which previous studies focused and to induce clustered scientific landscape for two consecutive periods to identify intriguing areas for future research.ResultsA search of the database retrieved 2,957 documents. There was a wave-like pattern in the number of publications until 2017, after which there was a spike in publication volume. The USA, China, and Japan provided the majority of contributions. In terms of institution, Mayo Clin, Univ Newcastle, and Katholieke Univ Leuven were found to be the prolific institutions. Additionally, the results indicate that eastern Asian researchers contributed significantly to the global knowledge of literature that led other countries; however, Canada, the USA, Australia, England, and Germany were found to have the highest degree of betweenness centrality. Nicholas J. Talley, Jan Tack, Gerald Holtmann, Michael Camilleri, Ken Haruma, and Paul Moayyedi occupied the top positions based on productivity and centrality indicators. Six thematic clusters emerged (Helicobacter pylori infection; pathophysiological mechanisms of FD; extraintestinal co-morbidities and overlap syndromes associated with FD; herbal medicine in FD; diabetic gastroparesis; and dietary factors in FD). “Acupuncture,” “duodenal eosinophilia,” “gut microbiota,” and others were among the author keywords with rising prevalence.ConclusionIn FD research, eastern Asian countries have established themselves as major contributors with the highest publishing productivity; however, research has primarily been driven by North America, Europe, and Australia, where cooperation is generally more active and highly influential scientific results are produced. Our analysis suggests that increased investments, training of human resources, improved infrastructures, and expanded collaborations are essential to improving the quality of FD research in Asia. The emerging author keyword analysis suggests that eosinophil-mast cell axis, gut microbiota, mental disorders, and acupuncture are the key areas that attract researchers’ attention as future research boulevards. There is a highly skewed distribution of research output across Asia, with most focus on complementary and alternative medicine (CAM) coming from Chinese, Japanese, and South Korean centers. However, CAM remains an underexplored area of research in the context of FD, and it deserves greater research efforts in order to obtain quality scientific evidence. Furthermore, we propose that the research framework of CAM should not be limited to dysmotility; rather, it could be interpreted within a more holistic context that includes the brain-gut-microbiota axis, as well as novel concepts such as duodenitis, increased mucosal permeability, and infiltration and activation of eosinophils and mast cells, among others. Overall, we provided bibliometrics-based overviews of relevant literature to researchers from different backgrounds and healthcare professionals to provide an in-depth overview of major trends in FD research.

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Association between intestinal microbiome and inflammatory bowel disease: Insights from bibliometric analysis

Cited by 24 publications

References 83 publications

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

Mapping trends and hotspot regarding gastrointestinal microbiome and neuroscience: A bibliometric analysis of global research (2002–2022)

Relationship between gut microbiota and rheumatoid arthritis: A bibliometric analysis

Research trends in the field of the gut-brain interaction: Functional dyspepsia in the spotlight – An integrated bibliometric and science mapping approach

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