Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Zhang, Xiaomei; Yuan, Ning; Sun, Jianbin; Zhao, Xin; Du, Jing; Min, Nan; Zhang, Qiaoling; Ji, Linong

doi:10.1007/s12011-021-02887-9

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…However, this phenomenon was less apparent in men, which might be attributed to the lower incidence of AITD in men compared to women [38]. The relationship between snPBI, sPBI, and TgAb might follow a nearly U-shaped curve, consistent with the ndings of Zhang's study [39]. Notably, iodine in the serum is taken up by the thyroid gland, with a signi cant portion being absorbed by Tg.…”

Section: Discussionsupporting

confidence: 66%

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Song,

Xu,

Wang

et al. 2024

Preprint

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Objective Iodine deficiency results in elevated thyroglobulin (Tg) concentrations, with high iodine Tg being more immunogenic than low iodine Tg. The study investigated the correlation between serum iodine concentration and thyroglobulin autoantibody (TgAb) levels across diverse iodine nutritional statuses as determined by urine iodine concentration (UIC). Methods Demographic information was collected from 1,482 participants through a questionnaire. Blood and spot urine were collected to measure thyroid-stimulating hormone (TSH), TgAb, thyroid anti-peroxidase antibody (TPOAb), serum iodine (SIC), serum non-protein-bound iodine (snPBI), urine iodine (UIC), creatinine (UCr). Results The median UIC and SIC were 146.5 µg/L and 74.9 µg/L, respectively. A linear relationship was observed between SIC, snPBI, and serum-protein-bound iodine (sPBI) (P < 0.001). The 90% reference intervals for SIC, snPBI, and sPBI were 50.7-120.7 µg/L, 21.9–52.9 µg/L, and 19.7–77.9 µg/L, respectively. The prevalence of elevated TgAb levels was significantly higher in women than in men (P < 0.001). Both low and high levels of snPBI and sPBI were associated with an increased risk of elevated TgAb levels. In women, the risk of positive TgAb in the group below the reference value of snPBI (OR = 2.079, 95%CI: 1.166, 3.705) and sPBI (OR = 2.578, 95%CI: 1.419, 4.684) was higher. In men, the risk of positive TgAb in the group below the reference value of StI was higher (OR = 3.395, 95%CI: 1.286, 8.962). Conclusion Iodine might exert an influence on TgAb levels through its binding to proteins, primarily Tg, thereby altering the iodine content of Tg. The interplay of gender factors further enhanced the risk of TgAb emergence.

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Section: Discussionsupporting

confidence: 66%

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Song,

Xu,

Wang

et al. 2024

Preprint

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“…Of these, 53 were identified as potentially relevant after screening of titles and abstracts (with 89% agreement between reviewers) and 26 were identified as relevant following reading of the full texts (with 80% agreement between reviewers). These publications reported on 24 cohorts containing 42,503 participants ( Figure 1 , Supplementary Table S2 ) [ 11 , 12 , 13 , 14 , 16 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“… Urinary iodine concentration ( a – c ), iodine to creatinine ratio and birth weight (grams) ( d – f ), dichotomous ( a , d ), linear ( b , e ), and nonlinear ( c , f ) meta-analyses. CI: Confidence interval; Δ: Change in outcome [ 11 , 12 , 13 , 14 , 16 , 28 , 29 , 31 , 33 , 34 , 36 , 37 , 39 , 40 , 41 , 42 , 44 ]. …”

Section: Figurementioning

confidence: 99%

Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis

et al. 2023

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Background & aims: Iodine is important for thyroid function during pregnancy to support fetal growth, but studies of maternal iodine status and birth outcomes are conflicting. We aimed to quantify the association between iodine status and birth outcomes, including potential threshold effects using nonlinear dose–response curves. Methods: We systematically searched Medline and Embase to 10 October 2022 for relevant cohort studies. We conducted random-effects meta-analyses of urinary iodine concentration (UIC), iodine:creatinine ratio (I:Cr), and iodide intake for associations with birth weight, birth weight centile, small for gestational age (SGA), preterm delivery, and other birth outcomes. Study quality was assessed using the Newcastle-Ottawa scale. Results: Meta-analyses were conducted on 23 cohorts with 42269 participants. Birth weight was similar between UIC ≥ 150 μg/L and <150 μg/L (difference = 30 g, 95% CI −22 to 83, p = 0.3, n = 13, I2 = 89%) with no evidence of linear trend (4 g per 50 μg/L, −3 to 10, p = 0.2, n = 12, I2 = 80%). I:Cr was similar, but with nonlinear trend suggesting I:Cr up to 200 μg/g associated with increasing birthweight (p = 0.02, n = 5). Birthweight was 2.0 centiles (0.3 to 3.7, p = 0.02, n = 4, I2 = 0%) higher with UIC ≥ 150 μg/g, but not for I:Cr. UIC ≥ 150 μg/L was associated with lower risk of SGA (RR = 0.85, 0.75 to 0.96, p = 0.01, n = 13, I2 = 0%), but not with I:Cr. Conclusions: The main risk of bias was adjustment for confounding, with variation in urine sample collection and exposure definition. There were modest-sized associations between some measures of iodine status, birth weight, birth weight centile, and SGA. In pregnancy, we recommend that future studies report standardised measures of birth weight that take account of gestational age, such as birth weight centile and SGA. Whilst associations were modest-sized, we recommend maintaining iodine sufficiency in the population, especially for women of childbearing age on restricted diets low in iodide.

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“…Anions play crucial roles in life health, pharmacy, molecular catalysis, and environmental sciences [ 1 , 2 , 3 , 4 ]. Abnormal levels of small molecules, such as iodide ions (I − ), in biological systems could be critical indicators of certain diseases and pose risks to human physiological functions [ 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

A “Pincer” Type of Acridine–Triazole Fluorescent Dye for Iodine Detection by Both ‘Naked-Eye’ Colorimetric and Fluorometric Modes

Yu,

Jiang,

Mou

et al. 2024

Molecules

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Iodine, primarily in the form of iodide (I−), is the bioavailable form for the thyroid in the human body. Both deficiency and excess intake of iodide can lead to serious health issues, such as thyroid disease. Selecting iodide ions among anions has been a significant challenge for decades due to interference from other anions. In this study, we designed and synthesized a new pincer-type acridine–triazole fluorescent probe (probe 1) with an acridine ring as a spacer and a triazole as a linking arm attached to two naphthol groups. This probe can selectively recognize iodide ions in a mixed solvent of THF/H2O (v/v, 9/1), changing its color from colorless to light yellow, making it suitable for highly sensitive and selective colorimetric and fluorescent detection in water systems. We also synthesized another molecular tweezer-type acridine–triazole fluorescent probe (probe 2) that exhibits uniform detection characteristics for iodide ions in the acetonitrile system. Interestingly, compared to probe 2, probe 1 can be detected by the naked eye due to its circulation effect, providing a simple method for iodine detection. The detection limit of probe 1 is determined to be 10−8 mol·L−1 by spectrometric titration and isothermal titration calorimetry measurements. The binding stoichiometry between probe 1 and iodide ions is calculated to be 1:1 by these methods, and the binding constant is 2 × 105 mol·L−1.

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Association Between Iodine Nutritional Status and Adverse Pregnancy Outcomes in Beijing, China: a Single-Center Cohort Study

Cited by 9 publications

References 24 publications

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Exploring the Correlation Between Varied Serum Iodine Nutritional Levels and Anti-Thyroglobulin Antibodies

Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis

A “Pincer” Type of Acridine–Triazole Fluorescent Dye for Iodine Detection by Both ‘Naked-Eye’ Colorimetric and Fluorometric Modes

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