Association between Irritable Bowel Syndrome and Allergic Diseases: To Make a Case for Aeroallergen

Wang, De Yun; Siah, Kewin Tien Ho

doi:10.1159/000503629

Cited by 21 publications

(21 citation statements)

References 103 publications

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“…IBS can overlap with non-celiac gluten sensitivity, with controlled studies showing an improvement of patients after the dietary exclusion of wheat [37]. Interestingly, children with atopic disease are at greater risk of developing IBS than non-atopic children [185]. A subset of patients with IBS have positive colonoscopic food allergen provocation with localized mucosal wheal and flare reactions [186] and the improvement of symptoms with cromoglycates [187], suggesting a potential role of food allergens in the pathogenesis of IBS.…”

Section: Role Of Food Allergens In Other Common Pediatric Gastrointesmentioning

confidence: 99%

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

2020

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Non-immunoglobulin E-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) include food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP), which present with symptoms of variable severity, affecting the gastrointestinal tract in response to specific dietary antigens. The diagnosis of non-IgE-GI-FA is made clinically, and relies on a constellation of typical symptoms that improve upon removal of the culprit food. When possible, food reintroduction should be attempted, with the documentation of symptoms relapse to establish a conclusive diagnosis. Management includes dietary avoidance, nutritional counselling, and supportive measures in the case of accidental exposure. The prognosis is generally favorable, with the majority of cases resolved before school age. Serial follow-up to establish whether the acquisition of tolerance has occurred is therefore essential in order to avoid unnecessary food restriction and potential consequent nutritional deficiencies. The purpose of this review is to delineate the distinctive clinical features of non-IgE-mediated food allergies presenting with gastrointestinal symptomatology, to summarize our current understanding of the pathogenesis driving these diseases, to discuss recent findings, and to address currents gaps in the knowledge, to guide future management opportunities.

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Section: Role Of Food Allergens In Other Common Pediatric Gastrointesmentioning

confidence: 99%

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

2020

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“…The relationship between food allergies and recurrent abdominal pain, IBS in particular, has also been widely explored. 92 Some studies have shown an improvement in the severity and the frequency of pain in pediatric patients under fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) exclusive-regime. 93 In addition, the role of food on their symptoms is often expressed by IBS patients, whether they are adults or children.…”

Section: Irritable Bowel Syndromementioning

confidence: 99%

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

Lenglart

Caula

Moulding

et al. 2021

J Neurogastroenterol Motil

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Migraine is one of the most frequent causes of primary headache and 9% of children suffer from migraines. Most children will continue to experience migraine attacks as adults, therefore it is imperative that we have a thorough understanding of this major health issue. This article considers the so-called abdominal variants of migraine, which are more commonly seen in children rather than adults: abdominal migraine, cyclic vomiting syndrome, and infantile colic. Other functional abdominal pain disorders such as irritable bowel syndrome and functional dyspepsia have also been linked to migraine in clinical studies. The common pathophysiological root of these diseases seems to be the gut-brain axis mechanism. Abdominal variants of migraine are considered pediatric precursors of migraine whereas the functional abdominal pain disorders related to migraine seem to share a pathophysiological root with no temporarily link as for today. In this review we aim to describe the epidemiological background, the current pathophysiological theories and the relationship of each disease to migraine. This review is the first to compile abdominal variants of migraine and functional abdominal pain disorders associated with migraine and we endeavor to elucidate the broad spectrum of migraine-related episodes in children.

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“…Most, but not all, studies have shown an association between FAPDs and allergic conditions [ 58 ]. FD and functional abdominal pain have been associated with asthma in adolescents [ 58 ].…”

Section: Allergy and Functional Abdominal Pain Disordersmentioning

confidence: 99%

“…Most, but not all, studies have shown an association between FAPDs and allergic conditions [ 58 ]. FD and functional abdominal pain have been associated with asthma in adolescents [ 58 ]. Likewise, asthma and food allergy, allergic rhinitis, and eczema have been associated with FAPDs in adults [ 59 , 60 , 61 , 62 , 63 , 64 ].…”

Section: Allergy and Functional Abdominal Pain Disordersmentioning

confidence: 99%

“…In addition, adults with IBS have an increased risk of seasonal allergies (and consequently pollen-food syndrome), and seasonal allergic rhinitis is associated with greater IBS severity [ 61 ]. Aeroallergens enter the nasal and oral cavities with breathing and may be swallowed, or they may be ingested following food contamination [ 58 ]. In children with FAPDs, local pollen counts are associated with the onset of pain and are as strong a predictor as are affect or sleep disturbances [ 80 ].…”

Section: Allergy and Functional Abdominal Pain Disordersmentioning

confidence: 99%

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Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

2021

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Both functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and most studies report an association between FAPDs and allergic conditions. FAPDs share pathophysiologic processes with allergies, including both immune and psychological processes interacting with the microbiome. No conclusive data are implicating IgE-mediated reactions to foods in FAPDs; however, there may be patients who have IgE reactions localized to the gastrointestinal mucosa without systemic symptoms that are not identified by common tests. In FAPDs, the data appears stronger for aeroallergens than for foods. It also remains possible that food antigens initiate an IgG reaction that promotes mast cell activation. If a food allergen is identified, the management involves eliminating the specific food from the diet. In the absence of systemic allergic symptoms or oral allergy syndrome, it appears unlikely that allergic triggers for FAPDs can be reliably identified by standard testing. Medications used to blunt allergic reactions or symptomatically treat allergic reactions may be useful in FAPDs. The purpose of the current manuscript is to review the current literature regarding the role of allergy in FAPDs from a clinical perspective, including how allergy may fit in the current model of FAPDs.

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Association between Irritable Bowel Syndrome and Allergic Diseases: To Make a Case for Aeroallergen

Cited by 21 publications

References 103 publications

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

Non-IgE-Mediated Gastrointestinal Food Allergies in Children: An Update

Brain to Belly: Abdominal Variants of Migraine and Functional Abdominal Pain Disorders Associated With Migraine

Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

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