Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis

Abstract

IntroductionThe results of the earlier published studies on the association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma (HCC) risk are inconclusive. Hence, we performed this meta-analysis to evaluate the relationship between KIF1B (rs17401966) polymorphism and HCC risk.MethodsDatabases including PubMed, Web of Science and the Cochrane Library and bibliographies of relevant papers were screened to identify relevant studies published up to March 25, 2018. Pooled ORs and 95% CIs were calculated to evaluate the association. The subgroup analysis was conducted based on ethnicity, age, region and environment. A total of 19 studies from 11 eligible articles published from 2010 to 2016, with 8,741 cases and 10,812 controls, were included.ResultsThe pooled results indicated that the association between KIF1B (rs17401966) polymorphism and the decreased HCC risk was significant. Subgroup analysis stratified by ethnicity showed the same association in Chinese, but not in non-Chinese population. When stratified by age, both old and young patients showed a decrease in HCC risk. When stratified by region, we detected the same association in Chinese in southern China. Similarly when stratified by environment, we observed the same association in Chinese in inland areas; however, no statistically significant association was observed in those in coastal areas.ConclusionThis meta-analysis suggested that KIF1B (rs17401966) polymorphism could decrease HCC risk in Chinese and in overall population, but not in non-Chinese. This association remained significant in Chinese in southern China and inland areas, but not in those in northern and central China and coastal areas. Further large-scale multicenter studies are warranted to confirm these findings.

The role of kinesin family members in hepatobiliary carcinomas: from bench to bedside

“…By contrast, unlike the carcinogenic role of KIF14, another family member KIF1B has been reported to exert a protective role in HCC pathogenesis [ 55 ]. Relevant research mainly concentrated on the association between the KIF1B single nucleotide polymorphism (SNP) (represented by rs17401966) and susceptibility of HBV-related HCC carcinogenesis [ 56 – 58 ], noting that the polymorphisms of KIF1B (rs17401966) might be tightly connected with a protective effect against HCC, especially in HBV-infected individuals and the Chinese population [ 59 – 61 ]. However, such results have proved controversial [ 62 – 65 ], and large-scale and multi-population cohort research remains desired to further investigate and clarify the situation.…”