Association between lipid profiles and presence of carotid plaque

Abstract

It is indicated that lipids profiles are associated with carotid plaque and Atherosclerosis. However, studies about the relationship between serum lipid profiles and carotid plaque composition in Chinese Population is limited. We conducted a cross-sectional study among 3,214 participants between January 2015 and December 2017 in China, to investigate the association between various lipid profiles and the prevalence of carotid plaque. Logistic regression model was used to investigate the association between plasma lipid profiles and odds of carotid plaque. Analysis of covariance (ANCOVA) was used to compare the mean plasma lipid profiles among different number and composition of carotid artery plaques. HDL-C, Non-HDL-C levels, TC/HDL-C, LDL-C/HDL-C were significantly associated with the presence of carotid plaque; HDL-C, LDL-C, Non-HDL-C levels, TC/HDL-C, LDL-C/HDL-C were significantly associated with the presence of common carotid artery (CCA) plaque. Compare with participants without carotid plaque, increased level of LDL-C/HDL-C was found in those with echolucent/polytype plaque. Similarly, compared with participants without CCA plaque, increased level of LDL-C/HDL-C was found in those with echolucent plaque. In conclusion, we found that serum HDL-C, Non-HDLc level, TC/HDLc, and LDLc/HDLc were all associated with the prevalence of carotid plaque, and LDL-C/HDL-C differed among different group of carotid plaque composition.

Ferulic Acid Ameliorates Atherosclerotic Injury by Modulating Gut Microbiota and Lipid Metabolism

“…The effect of cafferic acid on hepatocellular carcinoma may be related to the modulation of the gut microbiota and metabolites ( Zhang et al, 2017 ). FA itself has been identified to modulate the gut microbiota in previous studies ( Liu et al, 2019 ; Ma et al, 2019 ), which is consistent with our finding here. These studies suggest that FA could possibly influence the gut microbiota through its product, mainly cafferic acid.…”

“…Cardiovascular and cerebrovascular diseases, which mainly develop from atherosclerosis, have become the leading cause of death worldwide, especially in developed countries ( Liu et al, 2019 ). Atherosclerosis is characterized by excessive cholesterol deposition within the intima, especially in the aorta and coronary artery.…”

Prevalence and cardiovascular risk factors of carotid plaque in rural-dwelling adults: a population-based study in Shandong, China

“…In this study, high LDL-C was also found to be related to multiple CPs, which was in line with a previous study [19]. Consistent with other previous studies [28,29], low HDL-C was also associated with CP in the present study, which suggested that HDL-C may be a protective factor for carotid atherosclerosis. It is worth noting that in this study, high total cholesterol was not only associated with the presence of CP, but also with irregular CP.…”

“…Some studies have examined the association between lipid pro les and CP, but got inconsistent results [19,[27][28][29]. High LDL-C was found to be associated with the presence of CP [19,27,29], which was consistent with our ndings. However, an Algeria study failed to prove the association between high LDL-C and CP [28].…”

“…In addition, a four-year follow-up study suggested that hypertension was associated with new intraplaque hemorrhage [25], which was found to co-exist with disruption of the plaque surface [26]. Some studies have examined the association between lipid pro les and CP, but got inconsistent results [19,[27][28][29]. High LDL-C was found to be associated with the presence of CP [19,27,29], which was consistent with our ndings.…”