Association between liver failure and hepatic UDP-glucuronosyltransferase activity in dairy cows with follicular cysts

Tanemura, Kouichi; Ohtaki, Tadatoshi; Kuwahara, Yasushi; Tsumagari, Shigehisa

doi:10.1292/jvms.15-0674

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…UGT2A3, UGT2B35, and UGT1A1 belong to UDP glucuronosyltransferase family (UGTs) (Tanemura et al, 2017 ). UGTs are the main phase II drug metabolic enzymes that can catalyze glucuronic acid from UDP-glucuronic acid (UDPGA) to transfer to exogenous substances, and improve water solubility of the receptor, then expel from the body.…”

Section: Resultsmentioning

confidence: 99%

Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology

Liu

Shi

et al. 2018

Front. Pharmacol.

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Liver fibrosis is a common pathological feature of many chronic liver diseases. Bupleurum marginatum Wall.ex DC (ZYCH) is a promising therapeutic for liver fibrosis. In this study, 25 compounds were isolated from ZYCH, and the effects of ZYCH on DMN-induced liver fibrosis in rats were evaluated. The optimal effect group (H-ZYCH group) was selected for further proteomic analysis, and 282 proteins were altered in comparison to the DMN model group (FC > 1.2 or < 0.83, p < 0.05). Based on GO annotation analysis, clusters of drug metabolism, oxidative stress, biomolecular synthesis and metabolism, positive regulation of cell growth, extracellular matrix deposition, and focal adhesion were significantly regulated. Then networks of the altered proteins and compounds was generated by Cytoscape. Importantly, triterpenoid saponins and lignans had possessed high libdock scores, numerous targets, important network positions, and strong inhibitory activity. These findings may suggest that triterpenoid saponins and lignans are important active compounds of ZYCH in liver fibrosis and targeted by proteins involved in liver fibrosis. The combination of network pharmacology with proteomic analysis may provide a forceful tool for exploring the effect mechanism of TCM and identifying bioactive ingredients and their targets.

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Section: Resultsmentioning

confidence: 99%

Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology

Liu

Shi

et al. 2018

Front. Pharmacol.

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“…Increased levels of circulating ALT may reflect the underlying liver pathology. A recent study that revealed half of FC cows with liver disorders, such as fatty liver and hepatitis ( 47 ). This finding suggests that liver disorders are well-connected to development of FC in dairy cows and that steroid hormone metabolism is delayed, resulting in the formation of FC ( 47 ).…”

Section: Discussionmentioning

confidence: 99%

“…A recent study that revealed half of FC cows with liver disorders, such as fatty liver and hepatitis ( 47 ). This finding suggests that liver disorders are well-connected to development of FC in dairy cows and that steroid hormone metabolism is delayed, resulting in the formation of FC ( 47 ). On the contrary, we observed that FC cows had lower plasma ALT levels, and we postulate that an enhanced hepatic lipid mobilization accounts for this phenomenon ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Early Warning for Ovarian Diseases Based on Plasma Non-esterified Fatty Acid and Calcium Concentrations in Dairy Cows

Yao

Cheng

et al. 2021

Front. Vet. Sci.

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Inactive ovaries (IO) and ovarian (follicular or luteal) cysts (FC or LC) are two common ovarian diseases leading to infertility in dairy cattle. Both disorders are associated with altered metabolites and hormones. There are currently no known effective biomarkers that can be used for early diagnosis of ovarian diseases. The purpose of this study was to identify the plasma biomarkers of ovarian diseases in Holstein dairy cows that facilitate an early diagnosis of the diseases and control its progression. The experiment was performed from 3 weeks postpartum and last for 7 weeks. Seventy-six multiparous Holstein cows (mean age, 4.36 years; weight, 635.63 kg) were divided into healthy control group (HC, n = 22), FC group (n = 18), LC group (n = 18) and IO group (n = 18) by rectal palpation or ultrasonography during the last 2 weeks before trial end. Blood was collected via tail vein for measurement of plasma energy metabolites, liver function indicators, minerals, and hormones at 3 and 8 weeks postpartum. Data were analyzed by Mann-Whitney U, Kruskal-Wallis, Spearman correlation, binary logistic regression analysis and receiver operating characteristic analysis, where applicable. At 8 weeks postpartum, FC cows had a more severe body condition score loss and these had greater levels of non-esterified fatty acids (NEFA) and estradiol, and lesser levels of alanine aminotransferase (ALT), progesterone and insulin-like growth factor 1 (IGF-1) levels than HC cows (P < 0.05). LC cows had a lower milk yield, higher NEFA and progesterone levels, and lower calcium, phosphorus and magnesium levels than HC cows (P < 0.05). IO cows had a lower body condition score, higher NEFA levels, and lower ALT, calcium, phosphorus, magnesium, estradiol, progesterone and IGF-1 levels than HC cows (P < 0.05). At 3 weeks postpartum, cows with ovarian diseases had greater (P < 0.05) concentrations of NEFA, and lesser concentrations of ALT, calcium, phosphorus and IGF-1 than HC cows. Early warning values for ovarian diseases were plasma NEFA concentrations >0.50 mmol/L, or calcium concentrations <2.02 mmol/L. Therefore, plasma NEFA and calcium could be used as early-warning indicators for ovarian diseases in dairy cows.

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“…Крім того, на порядок знизився показник прояву ендометриту, що, на нашу думку, пов'язано з нормалізацією гормонального (естрадіолпрогестеронового) профілю організму корів. Це також підтверджують дослідження іноземних авторів (Ortega et al, 2016;Tanemura et al, 2017;Kengaku et al, 2021). Висновки 1.…”

Section: обговоренняunclassified

Distribution, diagnostics of mycotoxins in feed and prevention of gynecologi-cal pathology in cows

Chekan

2022

SMLNUVMB

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The results of the study of the treatment of cows for gynecological pathology when feeding fodder affected by mycotoxins are given in a comparative aspect. To detect microscopic fungi and mycotoxins in fodder, organoleptic, physico-chemical, toxicological-biological chemical-mycological research methods and clinical methods for researching the condition of the organs of the reproductive system of cows using ultrasound diagnostics were used. The purpose of the research was the approval of methods of treatment of cows for gynecological pathology in conditions of feed contamination with microscopic fungi and their toxins. The tasks of the research were to study the species characteristics of microscopic fungi and their toxins in fodder for cows; establish the prevalence of microscopic fungi and their toxins; to determine the effectiveness of treatment of cows for mycotoxicosis in a comparative aspect with the use of sorbents and an estrogen inhibitor during gynecological dispensation. Black and spotted cows were used for research according to the principle of analogues, 4 groups were formed. The animals of the 1st group were healthy animals (n = 42), the animals of the 2nd experimental group (n = 43) were fed with a product based on eleolite (2.5 kg/t of feed), the cows of the 3rd group (n = 41) injected a means based on an estradiol inhibitor in a dose of 3 ml per animal, the 4th group of animals (n = 42) did not receive treatment during the experimental period. The mycotoxins deosinivalenol and zearalenol were found to be present in 22.02 % to 27.3 % of the examined feeds. At the same time, the presence of fungi of the genera Aspergillus and Fusarium was established from 1.45 % to 4.9 % of the studied samples. The best treatment effect was obtained in the 3rd group of cows. The number of cases of ovarian hypotrophy was 2.1 times lower compared to the 4th and 1.8 times lower in the 2nd group, but 1.3 times higher than the 1st group. Ovarian atrophy in cows of the 3rd group was 2 times lower than in the 2nd group and 5 times lower than in the 4th group. Pathologies such as endometritis and persistent yellow body were diagnosed at the same time and were 4.5 times less in cows of the 3rd group than in the 2nd and 10.1 times less than in the 4th. Taking into account the obtained data, it can be concluded that the use of a remedy based on celeotite reduced the manifestation of gynecological pathology due to mycotoxicosis by 1.65 times, and the use of a remedy based on an estradiol inhibitor by 3.94 times.

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Association between liver failure and hepatic UDP-glucuronosyltransferase activity in dairy cows with follicular cysts

Cited by 5 publications

References 33 publications

Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology

Bupleurum marginatum Wall.ex DC in Liver Fibrosis: Pharmacological Evaluation, Differential Proteomics, and Network Pharmacology

Early Warning for Ovarian Diseases Based on Plasma Non-esterified Fatty Acid and Calcium Concentrations in Dairy Cows

Distribution, diagnostics of mycotoxins in feed and prevention of gynecologi-cal pathology in cows

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