Association Between Marginal Jawbone Loss and Onset of Rheumatoid Arthritis and Relationship to Plasma Levels of RANKL

Abstract

Marginal jawbone loss preceded the clinical onset of RA symptoms, but this was observed only in nonsmokers. Moreover, marginal jawbone loss was significantly greater in RANKL-positive presymptomatic subjects compared with RANKL-negative presymptomatic subjects and was highest in presymptomatic subjects positive for both ACPA and RANKL.

Effect of avocado/soybean unsaponifiables on periodontal repair in rats with arthritis and induced periodontitis

“…Clinical studies have shown that, compared to patients with PD without arthritis, patients with rheumatoid arthritis have more severe PD with worse values in periodontal parameters. 14,15,17 It is important to note that, compared to the ART group, the greater amount of bone volume found in the ART/ASU group corroborates the previous findings showing that ASU promotes an improvement in periodontal repair, although not at the same level as that found in healthy animals in an earlier study. 10 It is important to note that the mainly statistical differences between the groups occurred at the early periods of evaluation, which may be related with the progressive periodontal repair observed after the ligature removal in this model.…”

“…The association of PD and ART has been investigated in cross-sectional studies, and ART has been considered a risk indicator for the presence of PD. 14,15 The difficulty of considering ART as a risk factor for periodontal disease is the fact that ART patients are usually under therapy with host response modulators, which modify PD progression. 25,26 However, experimental models that induce ART have been shown to increase bone loss in models of experimental periodontitis.…”

“…12 It has been proposed that the PD treatment with host response modulators has a more expressive effect in patients who present some systemic condition that changes the progression of tissue destruction or the response to periodontal therapy. 2,13 For example, compared to healthy individuals, patients with ART have more severe PD, with higher levels of periodontal inflammation, more dental loss, higher frequency of sites with advanced insertion loss and deeper periodontal pockets; 14,15 thus, patients with ART and PD can benefit from anti-arthritic therapy with ASU, because this drug has a mechanism for blocking inflammatory processes associated with the stimulation of connective tissue proliferation. 5,6 Due to this effect, this study aims to evaluate the effect of ASU administration on periodontal repair in animals with induced arthritis and periodontitis.…”

Individuals at risk of seropositive rheumatoid arthritis: the evolving story

“…Moreover, severe periodontitis, defined as marginal jawbone loss, was significantly associated with the developed RA in a cohort of presymptomatic individuals (Fig. ), particularly in those who are ACPA positive and have increased concentrations of RANKL . Together, these data support the notion that periodontitis can be a source of citrullinated antigens and that periodontitis is a risk factor for the development of RA.…”

Editorial: Marginal Jawbone Loss Is Associated With the Onset of Rheumatoid Arthritis and Is Related to the Plasma Level of RANKL

“…In this issue of Arthritis & Rheumatology , Kindstedt et al present data suggesting that periodontitis precedes the onset of RA . In this case–control study nested in a population‐based survey of cohorts in the Medical Biobank of Northern Sweden, radiographs were retrieved from dental offices before the occurrence of symptoms of RA in 45 presymptomatic subjects and 45 controls matched for age, sex, and smoking status who were selected at random.…”