Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China

Zhang, Jiayu; Gong, Ting-Ting; Huang, Yan-Hong; Li, Jing; Shu, Liu; Chen, Yanling; Li, Lili; Jiang, Cheng-Zhi; Chen, Zong-Jiao; Wu, Qi‐Jun

doi:10.1016/j.envres.2020.109643

Cited by 12 publications

(10 citation statements)

References 31 publications

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“…In a population based control study, Zhang, et al [45] found at that congenital malformations of cardiac septa were associated with exposure of pregnant women to PM 10 especially in the second trimester of their pregnancy while SO 2 exposures at any point during the pregnancy could lead to similar results. A synthesis of the findings of time series research in major Chinese cities namely Beijing, Shanghai, Chongqing, Shenyang, Wuhan, and Taiyuan further corroborated the existing notion that persistent exposure to minimum and short-term air pollution is associated mortality or morbidity [46].…”

Section: Air Pollution Challenges Facing Chinamentioning

confidence: 96%

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Antwi

Zhou

et al. 2021

Sustainability

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Despite the positive effect of industrialisation on health and quality of life indicators across the globe, it is also responsible for the release of chemical toxins into the environment. Thus, the pursuit of economic development through industrialisation has equally nurtured numerous environmental disasters with accompanying catastrophic health effects. China is one of the countries with high carbon emissions, but new policy changes have resulted in massive gains in controlling environmental damage while enhancing the environment-related quality of life. This paper combines the six-step integrative review strategy with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) strategy to determine appropriate exclusion and inclusion criteria to explore the available stock of literature. We note that overall pollution in China fell by 10% between 2014 and 2019 whereas the average fine particulate matter (PM2.5) concentration of 93 micrograms per cubic meter reduced by 47% by 2019. Beijing exhibited the top 200 most polluted cities in 2019 after recording the lowest PM2.5 ever. All cities that implemented the 2012 Environmental Air Quality Standards reduced the average concentration of PM2.5 and sulfur dioxide by 42–68% by the end of 2018. Improvements in freshwater quality and a decline in water pollution levels were recorded despite increases in economic growth, urbanisation, energy use, trade openness, and agriculture, all of which are major stimulants of pollution. Deterring environmental tariff, tight ecological inspections, closing down of non-compliant producers, heavy investment in environmental control, and the ambitious five year-plan to revitalise renewable energy goals emanating from China’s ecological civilisation masterplan are responsible for these improvements in air and water pollution. China needs to work more aggressively to consolidate the gains already made in order to quicken the actualisation of the ecological civilisation and beautiful China dream.

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Section: Air Pollution Challenges Facing Chinamentioning

confidence: 96%

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Antwi

Zhou

et al. 2021

Sustainability

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“…Spina bifida (International Classification of Diseases, 10th, Clinical Modification code Q05) was diagnosed by clinical and imaging examinations until the end of infancy. The selection of unaffected controls has been reported in full ( 19 , 23 ). Briefly, we divided Liaoning Province into three geographical regions and selected healthy livebirths without any birth defects born in five cities (Shenyang, Dalian, Fuxin, Chaoyang, and Huludao) in three regions as the source of controls based on the birth population proportion, which can well-cover the province's different degrees of air pollution and economic development.…”

Section: Methodsmentioning

confidence: 99%

“…The data collection process of the registry has been described in detail ( 19 , 21 , 24 ). In brief, a three-level (county, province, and central) surveillance network as well as corresponding expert groups were set up to deal with daily data collection.…”

Section: Methodsmentioning

confidence: 99%

“…The study population included all livebirths, stillbirths, and induced abortions enrolled within the Maternal and Child Health Certificate Registry of Liaoning Province between 1 January 2010 and 31 December 2015. A detailed description of the registry is available in our previous studies (18)(19)(20). In short, this birth registry throughout the whole province was set up in 1988 and monitored nearly 6,000 cases of birth defects per year during the study period.…”

Section: Study Populationmentioning

confidence: 99%

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Maternal PM10 Exposure Increases Risk for Spina Bifida: A Population-Based Case-Control Study

Huang

et al. 2021

Front. Public Health

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Limited studies have focused on the impact of ambient air pollution on spina bifida. A population-based case-control study was conducted in Liaoning Province, China to assess the associations between maternal PM10 exposures in various exposure windows and spina bifida risk. Data on spina bifida cases born between 2010 and 2015 were available from the Maternal and Child Health Certificate Registry of Liaoning Province. Controls were a random sample of healthy livebirths without any birth defects delivered in the selected five cities during 2010–2015. Ambient air monitoring data for PM10 were obtained from 75 monitoring stations in Liaoning Province. The multivariable logistic regression models were established to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI). We further performed sensitivity analyses by using three propensity score methods. A total of 749 spina bifida cases and 7,950 controls were included. After adjusting for potential confounders, spina bifida was associated with a 10 μg/m3 increment in PM10 during the first trimester of pregnancy (adjusted OR = 1.06, 95% CI: 1.00–1.12) and the 3 months before pregnancy (adjusted OR = 1.12, 95% CI: 1.06–1.19). The adjusted ORs in the final model for the highest vs. the lowest quartile were 1.51 (95% CI: 1.04–2.19) for PM10 during the first trimester of pregnancy and 2.01 (95% CI: 1.43–2.81) for PM10 during the 3 months before pregnancy. Positive associations were found between PM10 exposures during the single month exposure windows and spina bifida. Sensitivity analyses based on two propensity score methods largely reported similar positive associations. Our findings support the evidence that maternal PM10 exposure increases the risk of spina bifida in offspring. Further, validation with a prospective design and a more accurate exposure assessment is warranted.

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“…In a population based control study, Zhang, Gong et al (2020)found at that congenital malformations of cardiac septa were associated with exposure of pregnant women to PM 10 especially in the 2 nd trimester of their pregnancy while SO 2 exposures at any point during the pregnancy could lead to similar results.…”

Section: Main Environmental Health Challenges Facing Chinamentioning

confidence: 96%

Progressing Towards Environmental Health Targets in China: A Systematic Review of Achievements in Air and Water Pollution under the “Ecological Civilization and the Beautiful China” Dream

Antwi¹

2020

Preprint

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Despite the positive effect of industrialization on health and quality of life indicators across the globe, it is also responsible for the release of chemical toxins into the environment and has nurtured numerous environmental disasters with severe health effects. China alone produces more than a third of carbon emissions in the world and currently has the second highest number of pollution-related deaths, after India. There is no issue that underscores the challenges of environmental crisis in China than the gradual acceptance of the existence of the cancer villages. These are entire towns that have been completely written off as so polluted that simply living there is synonymous with high rate of cancer risk. For years, residents and advocacy groups in villages such as Wuli, Yanglingang, Yangqiao and additional 459 identified cancer villages have waged a desperate war to turn the attention of government to the high risk of stomach, liver, kidney and colon cancer in these areas located near heavy industrial complexes. China responded by promoting an ecological civilization and a beautiful China dream as its sustainability blueprint in 2012. Today, this blueprint has been engraved into the national ideology for socio-economic and political orientation. This review therefore revisits the progress made towards environmental health targets under China’s sustainable development strategy. The study systematic explores the extant works on air and water pollution since the “Ecological Civilization and the Beautiful China” Dream.

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Association between maternal exposure to PM10 and polydactyly and syndactyly: A population-based case-control study in Liaoning province, China

Cited by 12 publications

References 31 publications

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Progressing towards Environmental Health Targets in China: An Integrative Review of Achievements in Air and Water Pollution under the “Ecological Civilisation and the Beautiful China” Dream

Maternal PM10 Exposure Increases Risk for Spina Bifida: A Population-Based Case-Control Study

Progressing Towards Environmental Health Targets in China: A Systematic Review of Achievements in Air and Water Pollution under the “Ecological Civilization and the Beautiful China” Dream

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