Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2 years of age- CHECK cohort study

Kim, Sunmi; Eom, Soyong; Kim, Hai Joong; Lee, Jeong Jae; Choi, Gyuyeon; Choi, Sang Chul; Kim, Sungjoo; Kim, Su Young; Cho, Geum-Joon; Kim, Young Don; Suh, Eunsook; Kim, Sung Koo; Kim, Seung Hyo; Kim, Gun Ha; Moon, Hyo Bang; Park, Jeongim; Kim, Sungkyoon; Choi, Kyungho; Eun, So Hee

doi:10.1016/j.scitotenv.2017.12.058

Cited by 158 publications

(94 citation statements)

References 62 publications

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“…Gascon et al reported higher levels of BDE-47 in female cord blood than in that of males but did not assess effect measure modification by sex [24]. Chen et al, Cowell et al, Sagiv et al, Vuong et al (2017a), and Kim et al investigated but found no indication of effect modification [28,30,31,35,37]. Sagiv et al and Vuong et al (2017a) did find signs of effect measure modification by sex of the association between childhood PBDE exposure and neurodevelopment.…”

Section: Resultsmentioning

confidence: 99%

“…All analyses were derived from longitudinal birth cohorts—three from Europe (France, Spain, and the Netherlands [23,24,25]); three from Asia (China, Taiwan, and Korea [26,27,28]); and three from North America. The North American birth cohorts were: CHAMACOS in Salinas Valley, California [29,30], HOME in Cincinnati, Ohio [31,32,33,34,35,36], and World Trade Center in New York, New York [37,38].…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Six of the studies (in the WTC, CHAMACOS, INMA, and COMPARE cohorts) measured exposure prior to 2004 [23,24,29,30,37,38], the year when penta- and octa-BDEs were phased out or banned in their respective locations, and seven studies (in the HOME and PELAGIE cohorts) measured exposure between 2002 and 2006 and included the year of congener removal in the enrollment window [31,32,33,34,35,36]. The studies in Asia were conducted in 2009 [27], 2011–2012 [28], and 2012 [26], but no regulation currently exists for PBDE exposure in either China or Korea [39], and Taiwanese regulation did not take effect until 2016. Depending on the study, prenatal PBDE exposure was measured in either maternal and/or cord blood.…”

Section: Summary Of Studiesmentioning

confidence: 99%

“…Dyads were followed from birth through between one and twelve years of age. Results were reported in terms of a shift in the population distribution of outcome scores, using estimated betas from linear regression based on one or multiple measures of exposure and outcome in HOME, PELAGIE, CHAMACOS, WTC, CHECK, and the Laizhou Wan cohorts [25,26,28,29,30,31,32,33,34,35,36,38], and in terms of group odds or risk of outcomes, using odds ratios in HOME, CHAMACOS, and the Taiwanese cohort [27,29,31], risk ratios in INMA [24], and incidence rate ratios in WTC [37]. One study reported correlations between exposure and outcomes [23].…”

Section: Summary Of Studiesmentioning

confidence: 99%

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Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Gibson

Siegel

Eniola

et al. 2018

IJERPH

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Polybrominated Diphenyl Ether (PBDE) flame retardants are environmental chemicals that cross the placenta during pregnancy and have shown evidence of neurotoxicity. As the in utero period is a sensitive developmental window, such exposure may result in adverse childhood outcomes. Associations between in utero PBDE exposure and neurodevelopment are found in animal models and increasingly in human population studies. Here, we review the epidemiological evidence of the association between prenatal exposure to PBDEs and motor, cognitive, and behavioral development in infants and children. Published work suggests a negative association between PBDE concentrations and neurodevelopment despite varying PBDE congeners measured, bio-specimen matrix used, timing of the biological sampling, geographic location of study population, specific developmental tests used, age of children at time of testing, and statistical methodologies. This review includes 16 published studies that measured PBDE exposure in maternal blood during pregnancy or in cord blood at delivery and performed validated motor, cognitive, and/or behavioral testing at one or more time during childhood. We evaluate possible mediation through PBDE-induced perturbations in thyroid function and effect measure modification by child sex. While the majority of studies support an adverse association between PBDEs and neurodevelopment, additional research is required to understand the mechanism of action, possibly through the perturbations in thyroid function either in the pregnant woman or in the child, and the role of biologically relevant effect modifiers such as sex.

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Section: Resultsmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

Section: Summary Of Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Gibson

Siegel

Eniola

et al. 2018

IJERPH

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“…For arid and semiarid regions, groundwater resources are especially important in terms of quantity and quality. Under these climatic conditions, groundwater overconsumption has led to decreased quality or contamination that may impose hazards to society [4,5]. Especially, heavy metals are important to monitor due to their toxicity.…”

Section: Introductionmentioning

confidence: 99%

Use of Heavy Metal Content and Modified Water Quality Index to Assess Groundwater Quality in a Semiarid Area

Maskooni

Naseri-Rad

Berndtsson

et al. 2020

Water

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Groundwater is a major source of drinking and agricultural water supply in arid and semiarid regions. Poor groundwater quality can be a threat to human health especially when it is combined with hazardous pollutants like heavy metals. In this study, an innovative method involving entropy weighted groundwater quality index for both physicochemical and heavy metal content was used for a semiarid region. The entropy weighted index was used to assess the groundwater’s suitability for drinking and irrigation purposes. Thus, groundwater from 19 sampling sites was used for analyses of physicochemical properties (electrical conductivity—EC, pH, K+, Ca2+, Na+, SO42−, Cl−, HCO3−, TDS, NO3−, F−, biochemical oxygen demand—BOD, dissolved oxygen—DO, and chemical oxygen demand—COD) and heavy metal content (As, Ca, Sb, Se, Zn, Cu, Ba, Mn, and Cr). To evaluate the overall pollution status in the region, heavy metal indices such as the modified heavy metal pollution index (m-HPI), heavy metal evaluation index (HEI), Nemerow index (NeI), and ecological risks of heavy metals (ERI) were calculated and compared. The results showed that Cd concentration plays a significant role in negatively affecting the groundwater quality. Thus, three wells were classified as poor water quality and not acceptable for drinking water supply. The maximum concentration of heavy metals such as Cd, Se, and Sb was higher than permissible limits by the World Health Organization (WHO) standards. However, all wells except one were suitable for agricultural purposes. The advantage of the innovative entropy weighted groundwater quality index for both physicochemical and heavy metal content, is that it permits objectivity when selecting the weights and reduces the error that may be caused by subjectivity. Thus, the new index can be used by groundwater managers and policymakers to better decide the water’s suitability for consumption.

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Hazard Identification (Humans)

Paustenbach,

Wenning

2024

Human and Ecological Risk Assessment

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Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2 years of age- CHECK cohort study

Cited by 158 publications

References 62 publications

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Effects of Polybrominated Diphenyl Ethers on Child Cognitive, Behavioral, and Motor Development

Use of Heavy Metal Content and Modified Water Quality Index to Assess Groundwater Quality in a Semiarid Area

Hazard Identification (Humans)

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