Association between MATN-3 Gene Polymorphism and Primary Knee Osteoarthritis in Indian Population: A Community-Based Case-Control Study

Matrilin-3 gene polymorphism in primary knee osteoarthritis: An Evidence based systematic review

“…[20][21][22][23] To conclude, two among three studies has amply proven association of OA Knee and matrilin gene 3. 20,21 The thirds Indian studies could not found that association but the third study was smaller in sample size and study duration .The other explanation to this different conclusion of Indian study could be the difference in ethnicity too. 23 On that account of geographical location, all three studies have uncanny similarities of belonging to north east area of respective countries.…”

“…Notably, genotype and allele frequency were not significantly associated with the severity of the disease in the Indian population. 20 One of the reasons behind these observations could be the small sample size involved in the study. Another reason as per the researcher "may be already the existence of MATN3 gene mutation in the Indian population, which is vindicated by us unable to find any association of MATN-3 with primary knee OA".…”

“…One more article in Google search was found as that journal was not PubMed indexed but on brighter note it was an study done on Indian population. 20 This third article is most recent, had Indian cohort and gave our review an ethnically wider population base to review the association of matrilin 3 in osteoarthritis knee.…”

“…The Egyptian and Indian case-control study included 50 primary knee OA patients (Group I) fulfilling the American College of Rheumatology (ACR) classification criteria of knee OA 22 who attended Benha University hospital and ELMC Lucknow hospital Uttar Pradesh, India respectively, together with 50 age and sex-matched apparently healthy controls (Group II) with no symptoms or signs on clinical examination or radiographic changes indicative of knee OA or other joint disease. 20,23 Our interesting observation was that Indian study seems to draw its inspiration from Egyptian therefore patient cohort, methodology, criterion for inclusion /exclusion seem to mirror each other. Both studies excluded the patient having isolated patello-femoral OA; secondary OA due to trauma or deformity; metabolic disorders such as diabetes mellitus, thyroid disorders, or Cushing syndrome; or renal failure or were undergoing dialysis; infectious disorders such as septic arthritis, viral arthritis, or fungal arthritis; ,inflammatory arthritis such as rheumatoid arthritis, systematic lupus erythematosus, and sero-negative arthritis; malignancy; bilateral knee replacements; or relatives included in the study.…”