Association between Matrix Metalloproteinase-2 with Bone Destruction Degree in Patients with Atticoantral Chronic Suppurative Otitis Media at Haji Adam Malik Central General Hospital, Medan, Indonesia

Wulandari, Richa Syafni Putri; Asroel, Harry Agustaf; Aboet, Askaroellah; Zaluchu, Fotarisman; Eliandy, Sutoyo

doi:10.15562/bmj.v7i3.865

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it has been observed that MMP-14, although expressed at lower levels than MMP-12 in polarized macrophages, can cleave endoglin, a membrane protein found in monocyte macrophages [16]. The role of endoglin in this context is of particular interest [17][18][19][20]. Macrophages play a crucial role in the development of atherosclerosis, which can be triggered by endothelial dysfunction, hypertension, vasculitis, aortic aneurysm, or other vascular disorders [21,22].…”

Section: Hypoxiamentioning

confidence: 99%

“…It is worth noting that GM-CSF monocyte-derived macrophage supernatants have MMP-12dependent inhibitory effects on endothelial tubulogenesis, which support the anti-angiogenic properties of soluble endoglin (sEng). MMP-12 [16,20] jd [27][28][29][30]. This study discovered that hyperbaric oxygen therapy reduced the expression of activated MMP-12 in Sprague Dawley rats with endothelial dysfunction.…”

Section: Hypoxiamentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2023

J. Med. Chem. Sci.

View full text Add to dashboard Cite

Background:The utilization and advancement of hyperbaric science continue to evolve, encompassing the investigation of cardiovascular disease. Macrophage activation stimulates the expression of matrix metalloproteinases, specifically MMP-12, which play a crucial role in atherosclerosis by influencing vascular tissue. Methods: This study aimed to examine MMP-12 expression in cardiovascular disease induced by an atherogenic high-fat diet and explore the effects of hyperbaric oxygen therapy. Previous research has focused on the primary mechanism of hyperbaric oxygen therapy through the SIRT1 (Sirtuin) pathway, which addresses endothelial dysfunction in atherosclerosis treatment. However, the impact of HBO utilization on the treatment and prevention of cardiovascular disease remains unexplored. Results: Molecular analysis of MMP-12 was conducted using a rat model administered a high-fat diet, followed by HBO treatment. Endothelial dysfunction caused by the high-fat diet was identified as a marker of cardiovascular disease, assessed by endothelin-1 (ET-1) levels. The administration of hyperbaric oxygen (HBO) yielded significant improvements in atherosclerosis and heart disease. The results, with a pvalue of 0.05, were significant for both the treatment and prevention of atherosclerotic heart disease in the two groups used as models. Conclusion: Sprague Dawley rats subjected to hyperbaric oxygen therapy at a pressure of 2.4 ATA, three sessions of 30 minutes each, for ten consecutive days, demonstrated potential for application in cardiovascular disease prevention and treatment.

show abstract