Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Guimarães, Vilma; Guimarães, Rafael Lima; Brandão, Lucas André Cavalcanti; Silva, Maria Fernanda Piffer Tomasi Baldez da; Milanese, Michele; Segat, Ludovica; Castelletti, Carlos Henrique Madeiros; Bruneska, Danyelly; Filho, José Luiz de Lima; Freitas, Antonio Carlos de; Arraes, Luiz Cláudio; Rocha, Cecília; Crovella, Sérgio

doi:10.1016/j.humimm.2008.03.002

Cited by 23 publications

(23 citation statements)

References 25 publications

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“…We had previously performed a similar study on Brazilian women [19]. In the Brazilian gynecologic group analyzed, we reported a significant association between MBL2 polymorphisms and the risk of being infected by high-risk HPV in women characterized by MBL2 combined genotypes responsible for a deficient production of MBL protein.…”

Section: Discussionmentioning

confidence: 92%

MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

et al. 2009

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Section: Discussionmentioning

confidence: 92%

MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

et al. 2009

Self Cite

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“…There are only few reports regarding the association between HPV and MBL [9][10][11][12]. Some authors showed that certain polymorphisms in the MBL2 gene were associated with higher susceptibility to infection by high-risk HPV genotypes [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Some authors showed that certain polymorphisms in the MBL2 gene were associated with higher susceptibility to infection by high-risk HPV genotypes [10][11][12]. Nevertheless, there are also studies showing no relationship between MBL2 polymorphisms and HPV infection [9].…”

Section: Introductionmentioning

confidence: 99%

MBL serum concentration in women with HPV presenting CIN III lesions

et al. 2013

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“…However, no statistically significant difference was found when stratifying the groups regarding MBL production, as previously reported [15,16]. Conversely, it has been reported that specific functional polymorphisms in the MBL2 gene could increase women's susceptibility to infection by high-risk HPV genotypes due to low MBL serum levels [14][15][16]. In addition, Zupin et al [24] suggested a possible association between MBL2 polymorphisms responsible for low MBL production and susceptibility to the development of atypical squamous cells of undetermined significance.…”

Section: Discussionmentioning

confidence: 83%

“…Conversely, higher levels of MBL could enhance tissue destruction due to unwarranted activation of complement [8,12]. In a few studies, an association between HPV and MBL has been reported [13][14][15][16]. Two of these studies [14][15][16] showed that certain polymorphisms in the MBL2 gene were associated with higher susceptibility to infection conferred by high-risk HPV genotypes, but another study [13] did not show any such association between MBL2 polymorphisms and HPV infection.…”

Section: Introductionmentioning

confidence: 99%

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

Maestri¹,

Nisihara²,

Ramos³

et al. 2017

Med Princ Pract

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Objective: To evaluate serum concentrations of mannose-binding lectin (MBL) in women presenting with different human papillomavirus (HPV)-associated cervical lesions. Subjects and Methods: A total of 364 women, who underwent screening for cervical cancer or treatment at the Erasto Gaertner Cancer Hospital (HEG), Curitiba, Brazil, were enrolled in the study. Based on the latest cervical colposcopy-guided biopsy results, the women were divided into 4 groups: cervical intraepithelial neoplasia CIN-I (n = 54), CIN-II (n = 72), CIN-III (n = 145), and invasive cancer (n = 93). A time-resolved immunofluorometric assay was used to measure the MBL concentrations in serum. The statistical analysis was done using GraphPad Prism 6.0. Comparisons were performed by Kruskal-Wallis and Mann-Whitney tests and analyzed by χ² test; continuous variables are presented as medians and categorical variables as frequencies. Results: The median MBL concentrations in decreasing order were as follows: invasive cancer: 1,452 ng/mL, CIN-I: 1,324 ng/mL, CIN-II: 1,104 ng/mL, and CIN-III 1,098 ng/mL. However, no statistical significance was found among the 4 groups with HPV-associated lesions (p = 0.11). Equally, the MBL levels did not show a significant association between the age of the patients and the severity of the cervical lesions (p = 0.68). No statistical significance was found in the median values of MBL or in the status of MBL deficient (<100 ng/mL) and high producers (>1,000 ng/mL) among the women in each group (p = 0.77). Conclusion: In this study, there was no statistically significant difference in MBL serum levels among the groups with CIN. Hence MBL serum concentration appeared not to have influenced the progression of HPV-related preinvasive cervical lesions into invasive cancer.

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Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women

Cited by 23 publications

References 25 publications

MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

MBL2 gene polymorphisms are correlated with high-risk human papillomavirus infection but not with human papillomavirus–related cervical cancer

MBL serum concentration in women with HPV presenting CIN III lesions

Mannose-Binding Lectin Does Not Act as a Biomarker for the Progression of Preinvasive Lesions of Invasive Cervical Cancer

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