Association between MCT1 T1470A polymorphism and athlete status in Japanese power-oriented athletes

Homma, Hiroki; Mochizuki, Yukina; SHINOGI, Maho; Kobatake, Naoyuki; Okamoto, Takanobu; Nishiyama, Tomoki; Nakazato, Koichi; Kikuchi, Naoki

doi:10.23736/s0393-3660.22.04883-5

Gazz Med Ital - Arch Sci Med

2023

DOI: 10.23736/s0393-3660.22.04883-5

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Association between MCT1 T1470A polymorphism and athlete status in Japanese power-oriented athletes

Hiroki Homma

Yukina Mochizuki

Maho SHINOGI

et al.

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2024

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Association Among MCT1 rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners

Seki,

Kobayashi,

Beppu

et al. 2024

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Background/Objectives: Monocarboxylate transporters (MCTs) comprise 14 known isoforms, with MCT1 being particularly important for lactate transport. Variations in lactate metabolism capacity and aerobic performance are associated with the T1470A polymorphism in MCT1. We aimed to investigate the frequency of the T1470A polymorphism and compare relevant physiological parameters among long-distance runners, wherein these parameters are fundamental to athletic performance. Methods: We included 158 Japanese long-distance runners (LD) and 649 individuals from the general Japanese population (CON). The frequency of the T1470A polymorphism was compared between these groups and across athletic levels using the chi-square test. Additionally, physiological data were collected from 57 long-distance runners, and respiratory gas measurements were obtained using the mixing-chamber method during a graded incremental exercise test. Results: We observed a significant difference between the LD and CON groups in the dominant model and between the sub-28 min group and 28 min or above group in the recessive model. As the competitive level increased, the frequency of the AA genotype also increased. When comparing physiological parameters between the AA genotype and T allele, subjects with the AA genotype showed significantly higher values for oxygen uptake at lactate threshold (p = 0.001), oxygen uptake at onset of blood lactate accumulation (p = 0.01), maximal oxygen uptake (p = 0.005), and maximal blood lactate concentration (p = 0.038). Conclusions: These results suggest that the AA genotype of the T1470A polymorphism of MCT1 is an effective genotype associated with athletic status and aerobic capacity in Japanese long-distance runners.

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Association Among MCT1 rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners

Seki,

Kobayashi,

Beppu

et al. 2024

Genes

View full text Add to dashboard Cite

show abstract

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Association between MCT1 T1470A polymorphism and athlete status in Japanese power-oriented athletes

Cited by 1 publication

References 19 publications

Association Among MCT1 rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners

Association Among MCT1 rs1049434 Polymorphism, Athlete Status, and Physiological Parameters in Japanese Long-Distance Runners

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