Association between mean platelet volume and coronary artery calcification in patients without overt cardiovascular disease: an observational study

Abstract

Objective: Platelets have an important role in the pathogenesis of atherothrombosis. It has been shown that platelet size measured by mean platelet volume (MPV), correlates with their reactivity and is still regarded as an easy, useful tool for indirect monitoring of platelet activity in different situations. Coronary artery calcification (CAC) has long been known to occur as a part of the atherosclerotic process. The aim of this study was to determine whether an association exists between MPV and CAC. Methods: In this observational study, we enrolled 259 participants with at least one cardiac risk factor but with unknown cardiovascular disease. Coronary calcification was assessed by multislice computerized tomography and MPV was measured in a blood sample collected in EDTA tubes. Statistical analysis was performed using Kruskal-Wallis, Chi-square, correlation tests and multiple regression analysis. Results: Calcium scores ranged from 0 to 735. There was a significant relation between CAC and MPV (r=0.24, p=0.02), age (r=0.32, p<0.001), hypertension (r=0.19, p=0.03), diabetes (r=0.16, p=0.005), smoking (r=0.17, p=0.001). In linear regression analysis, MPV (β=0.4,.1, p<0.001), age (β=0.13, 95%CI 0.23-2.4, p=0.01) and smoking (β=0.12, 95%CI 3.2-15.1, p=0.02) independently associated with CAC. In addition, there were significant differences in MPV between significant CAC group compared to the minimal and none (10.2±2.4 versus 8.1±0.9 and 7.6±1.3; p<0.001). Conclusion: We have found significant association between MPV and CAC. Although this study is purely correlative and no causative conclusions can be drawn, it may suggest that higher MPV may reflect increased atherosclerotic burden and cardiovascular risk. Yöntemler: Bu gözlemsel çalışmada, bilinen kardiyovasküler hastalığı olmayan ve en az bir kardiyovasküler riski olan 259 hasta çalışmaya alın-dı. KAK çok kesitli tomografi ile değerlendirildi. OTH ise etilen diamin tetra asetik asit (EDTA)'li tüplere alınan kanda ölçüldü. İstatistiksel analiz Kruskal-Wallis, Ki-kare, korelasyon testleri ve çoklu regresyon analiz ile yapıldı. Bulgular: Kalsiyum skoru 0 ile 735 arasında idi. Tek yönlü analizde KAK ile OTH (r=0.24, p=0.02), yaş (r=0.32, p<0.001), hipertansiyon (r=0.19, p=0.03), diyabet (r=0.16, p=0.005) ve sigara içimi (r=0.17, p=0.001) arasında anlamlı bir ilişki vardı. Çok yönlü analizde ise OTH (β=0.4, %95GA 19.8-31.1, p<0.001), yaş (β=0.13, %95GA 0.23-2.4 p=0.01) ve sigara içimi (β=0.12, %95GA 3.2-15.1, p=0.02) KAK'ın bağımsız belirleyicileri idi. Ayrıca anlamlı KAK'ı olanlarda minimal ya da KAK'ı olmayan hastalara göre OTH anlamlı olarak yüksek idi (10.2±2.4 karşı 8.1±0.9 ve 7.6±1.3; R 2 =52.7, p<0.001).

Mean platelet volume and arterial stiffness in patients with acromegaly

“…A relation was found between MPV and microalbuminuria which is an indicator of microangiopathy in patients with 2 DM (40). In the general population, a significant relationship was found between MPV and coronary artery calcification, which is a risk factor for coronary vascular events and mortality (15,41). Özlü et al (42) showed that increased MPV was established as an independent predictor of non-ST-segment elevation acute coronary syndromes (NSTE-ACS).…”

The correlation between the psoriasis area severity index and ischemia-modified albumin, mean platelet volume levels in patients with psoriasis

“…The volume increases in acute coronary syndrome and has been suggested as a new marker for early detection of cardiovascular risk factors such as atherosclerosis [13], metabolic syndrome [14], DM [14], arterial hypertension [15], and dyslipidemia [16]. …”

Mean platelet volume is not associated with coronary slow flow: A retrospective cohort study

“…In comparison to smaller ones, larger platelets are associated with other markers of platelet activity, including increased platelet aggregation, increased thromboxane synthesis and beta-thromboglobulin release, and increased expression of adhesion molecules (17, 18). Elevations of MPV values have also been shown in patients with CAD, insulin resistance such as metabolic syndrome, obesity, impaired fasting glucose, diabetes mellitus, hypertension, stroke, hypercholesterolemia, and smoking suggesting a common mechanism by which these factors may increase the risk of cardiovascular disease (15, 19-22). …”