Association between MEG3 polymorphisms (rs941576 and rs7158663) and risk of acute ischemic stroke in Egyptian patients

Shaker, Olfat; Sroor, Wafaa; Ali, Ola; Soliman, Hanan; Abdeen, Marwa

doi:10.1016/j.genrep.2021.101286

Cited by 2 publications

(6 citation statements)

References 50 publications

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“…These observations recapitulate the findings of a prior study which reported the association of the MEG3 rs941576 AG + GG genotype with disease-free survival in breast cancer patients 19 . In addition, two Egyptian studies have also uncovered the association of rs941576 polymorphism with acute ischemic stroke and rheumatoid arthritis risk 38 , 39 . While the G allele and GG genotype of this SNP was regarded as risk factors for acute ischemic stroke 38 , the major A allele was associated with rheumatoid arthritis risk 39 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, two Egyptian studies have also uncovered the association of rs941576 polymorphism with acute ischemic stroke and rheumatoid arthritis risk 38 , 39 . While the G allele and GG genotype of this SNP was regarded as risk factors for acute ischemic stroke 38 , the major A allele was associated with rheumatoid arthritis risk 39 . The later study reported the mechanistic impact of rs941576 in rheumatoid arthritis; the AA genotype carriers exhibited a significantly decreased serum MEG3 expression and BAX levels and increased hypoxia-inducible factor-1α and vascular endothelial growth factor levels 39 .…”

Section: Discussionmentioning

confidence: 99%

“…The following selection criteria were implemented: a global minor allele frequency (MAF) greater than 10% reported in HapMap, reported in a prior GWAS study, has a recorded association with cancer risk, and previously studied in the Egyptian population. rs941576 was the only SNP previously linked to type 1 diabetes risk in a GWAS study 37 and breast cancer risk in a population study 19 , and has been associated with the risk of acute ischemic stroke and rheumatoid arthritis in Egyptian patients 38 , 39 . Thus, this SNP has been selected for this study.…”

Section: Methodsmentioning

confidence: 98%

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Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights

Senousy,

Shaker,

Ayeldeen

et al. 2024

Sci Rep

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The identification of novel screening tools is imperative to empower the early detection of colorectal cancer (CRC). The influence of the long non-coding RNA maternally expressed gene 3 (MEG3) rs941576 single nucleotide polymorphism on CRC susceptibility remains uninvestigated. This research appraised MEG3 rs941576 association with the risk and clinical features of CRC and obesity-related CRC and its impact on serum MEG3 expression and its targets miR-27a/insulin-like growth factor 1 (IGF1)/IGF binding protein 3 (IGFBP3) and miR-181a/sirtuin 1 (SIRT1), along with the potential of these markers in obesity-related CRC diagnosis. 130 CRC patients (60 non-obese and 70 obese) and 120 cancer-free controls (64 non-obese and 56 obese) were enrolled. MEG3 targets were selected using bioinformatics analysis. MEG3 rs941576 was associated with magnified CRC risk in overall (OR (95% CI) 4.69(1.51–14.57), P = 0.0018) and stratified age and gender groups, but not with obesity-related CRC risk or MEG3/downstream targets’ expression. Escalated miR-27a and IGFBP3 and reduced IGF1 serum levels were concomitant with MEG3 downregulation in overall CRC patients versus controls and obese versus non-obese CRC patients. Serum miR-181a and SIRT1 were upregulated in CRC patients versus controls but weren’t altered in the obese versus non-obese comparison. Serum miR-181a and miR-27a were superior in overall and obesity-related CRC diagnosis, respectively; meanwhile, IGF1 was superior in distinguishing obese from non-obese CRC patients. Only serum miR-27a was associated with obesity-related CRC risk in multivariate logistic analysis. Among overall CRC patients, MEG3 rs941576 was associated with lymph node (LN) metastasis and tumor stage, serum MEG3 was negatively correlated with tumor stage, while SIRT1 was correlated with the anatomical site. Significant correlations were recorded between MEG3 and anatomical site, SIRT1 and tumor stage, and miR-27a/IGFBP3 and LN metastasis among obese CRC patients, while IGF1 was correlated with tumor stage and LN metastasis among non-obese CRC patients. Conclusively, this study advocates MEG3 rs941576 as a novel genetic marker of CRC susceptibility and prognosis. Our findings accentuate circulating MEG3/miR-27a/IGF1/IGFBP3, especially miR-27a as valuable markers for the early detection of obesity-related CRC. This axis along with SIRT1 could benefit obesity-related CRC prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 98%

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Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights

Senousy,

Shaker,

Ayeldeen

et al. 2024

Sci Rep

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“…Nowadays, despite the great focus in the literature on finding the association between various MEG3 gene SNPs and several diseases, up till now, to the best of our knowledge, there has not been so much research work on investigating MEG3 SNPs that are associated with stroke. So far, there has been two published studies to find association of some MEG3 SNPs with ischemic stroke susceptibility of Han people 13 and Egyptians 14 .…”

Section: Association Between Meg3 Polymorphisms and Strokementioning

confidence: 99%

“…SNPs could disorder the secondary structure of the lncRNAs, affecting their molecular function and having an effect on their expression pattern 11 . SNPs in MEG3 gene, also, have their contributory roles and many studies proved the association between different genetic variants of MEG3 and several diseases, including ischemic stroke [12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

The Role of lncRNAs in Stroke: MEG3 as a Promising Candidate

Ali

Shaker

Sroor

et al. 2023

Azhar International Journal of Pharmaceutical and Medical Scien

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Globally, stroke is considered a major cause of incapacity and death. It results in high economic load to peoples in almost all countries. Numerous mechanisms have been anticipated to contribute to the pathophysiology of ischemic stroke, including epigenetic modification and dysregulation of some noncoding RNAs. In the recent years, there has been a great focus on studying long noncoding RNAs (lncRNAs) which have been recognized as possible biomarkers and therapeutic goals to treat ischemia. It was observed that maternally expressed gene 3 (MEG3)-lncRNA perform many functions and is implicated in the pathophysiology and/ or recovery of many diseases. Beside the high expression levels of MEG3 in brain, the upregulation of MEG3 after ischemic stroke was also observed. The current review sets sights on spotlighting the functions of lncRNAs, especially MEG3 in the pathogenesis of stroke as well as figuring out its genetic variants that are associated with various diseases, including stroke risk.

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Association between MEG3 polymorphisms (rs941576 and rs7158663) and risk of acute ischemic stroke in Egyptian patients

Cited by 2 publications

References 50 publications

Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights

Association of lncRNA MEG3 rs941576 polymorphism, expression profile, and its related targets with the risk of obesity-related colorectal cancer: potential clinical insights

The Role of lncRNAs in Stroke: MEG3 as a Promising Candidate

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