Association between Mental Disorders and Subsequent Medical Conditions

Momen, Natalie C.; Plana‐Ripoll, Oleguer; Agerbo, Esben; Benros, Michael E.; Børglum, Anders; Christensen, Maria Klitgaard; Dalsgaard, Søren; Degenhardt, Louisa; Jonge, Peter de; Debost, Jean Christophe P.G.; Fenger‐Grøn, Morten; Gunn, Jane; Iburg, Kim Moesgaard; Kessing, Lars Vedel; Kessler, Ronald C.; Laursen, Thomas Munk; Lim, Carmen C W; Mors, Ole; Mortensen, Preben Bo; Musliner, Katherine L.; Nordentoft, Merete; Pedersen, Carsten Bøcker; Petersen, Liselotte; Ribe, Anette Riisgaard; Roest, Annelieke M.; Saha, Sukanta; Schork, Andrew J.; Scott, Kate M.; Sievert, Carson; Sørensen, Holger J.; Stedman, Terry; Vestergaard, Mogens; Vilhjálmsson, Bjarni J.; Werge, Thomas; Weye, Nanna; Whiteford, Harvey; Prior, Anders; McGrath, John J.

doi:10.1056/nejmoa1915784

Cited by 323 publications

(320 citation statements)

References 39 publications

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“… 41 , 42 Risk factors for infection with SARS-CoV-2 and a severe course of COVID-19 include severe mental illness, alcohol or drug misuse, and homelessness, all of which are associated with other risk factors such as comorbid physical conditions. 43 , 44 , 45 People with mental disorders are at increased risk of infections in general (and thereby potentially at increased risk of COVID-19), 46 and are more likely to develop severe organ dysfunction and to die in ICUs than people without mental disorders. 47 SARS-CoV-2 might also cause dysregulation of the stress system, which could contribute to the development or exacerbation of psychiatric disorders.…”

Section: Potential Consequences Of Covid-19 For Mental Healthmentioning

confidence: 99%

How mental health care should change as a consequence of the COVID-19 pandemic

Moreno

Wykes

Galderisi

et al. 2020

The Lancet Psychiatry

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The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns, physical distancing, and other containment strategies; and the resulting economic breakdown could increase the risk of mental health problems and exacerbate health inequalities. Preliminary findings suggest adverse mental health effects in previously healthy people and especially in people with pre-existing mental health disorders. Despite the heterogeneity of worldwide health systems, efforts have been made to adapt the delivery of mental health care to the demands of COVID-19. Mental health concerns have been addressed via the public mental health response and by adapting mental health services, mostly focusing on infection control, modifying access to diagnosis and treatment, ensuring continuity of care for mental health service users, and paying attention to new cases of mental ill health and populations at high risk of mental health problems. Sustainable adaptations of delivery systems for mental health care should be developed by experts, clinicians, and service users, and should be specifically designed to mitigate disparities in health-care provision. Thorough and continuous assessment of health and service-use outcomes in mental health clinical practice will be crucial for defining which practices should be further developed and which discontinued. For this Position Paper, an international group of clinicians, mental health experts, and users of mental health services has come together to reflect on the challenges for mental health that COVID-19 poses. The interconnectedness of the world made society vulnerable to this infection, but it also provides the infrastructure to address previous system failings by disseminating good practices that can result in sustained, efficient, and equitable delivery of mental health-care delivery. Thus, the COVID-19 pandemic could be an opportunity to improve mental health services.

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Section: Potential Consequences Of Covid-19 For Mental Healthmentioning

confidence: 99%

How mental health care should change as a consequence of the COVID-19 pandemic

Moreno

Wykes

Galderisi

et al. 2020

The Lancet Psychiatry

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1,376

1,070

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“…In a worldwide survey conducted among more than 47.000 individuals across 17 countries, specific mental disorders were associated with 1.5–13.3% of physical condition onsets [ 5 ]. Recently, in a Danish cohort of 5.9 million people, there was a median hazard ratio of 1.37 of developing a medical condition if a psychiatric disorder was present [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Soto-Angona

Anmella

Valdés-Florido

et al. 2020

BMC Med

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Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.

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“…3 Besides the several implications of SMI in terms of poor quality of life and level of functioning, problems at work, social integration and stigma, the last two decades have seen much of the research focused on physical health, not on the integration of SMI and cancer care. 5,6 One of the most important and recognized problems is that people with SMI, especially schizophrenia, bipolar disorders and severe depressive disorders, have both an increase rate of morbidity because of somatic disorders and higher mortality rates, aside from cancer. [7][8][9] The provisional conclusions of these studies is that there is sufficient evidence that people with SMI are less likely to receive standard levels of care for most diseases, such as diabetes and heart disease associated with lifestyle factors.…”

mentioning

confidence: 99%

Cancer and severe mental illness: Bi‐directional problems and potential solutions

Grassi

Riba

2020

Psycho-Oncology

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Objective: Given the reported increased rates of physical morbidity and higher mortality rates among people with severe mental illness (SMI) (schizophrenia and severe mood disorders), with a life expectancy shorter of 15-20 years with respect to the general population, the aim of this paper was to call attention to the problem of cancer in SMI. Methods: We conducted a narrative review of the most significant papers published in the areas of cancer screening, incidence, mortality and palliative care in SMI. Results: Data from the literature confirm disparities in screening (eg, mammography; pap-smear test; colorectal cancer screening) and prevention (eg, clinical breast examination; smoking cessation). The incidence of cancer was found to be variable with a portion of the studies reporting a higher prevalence while others a similar or a lower prevalence of cancer compared to the general population. A lower percentage of patients with SMI received proper cancer treatment resulting in survival after cancer diagnosis significantly worse than people without SMI. Likewise, end-of-life care has been shown to be lacking with poorer levels of physical, psychological and spiritual care. Conclusions: The problems of stigma and discrimination, poorer dignity, poorer health behavior, lack of integration in health-care services for people with SMI needs to be addressed and solved in cancer care. Psycho-oncology has a very specific and mandatory role in integrating the recommendation of the World Health Organization to improve the links between oncology and mental health settings for more specific psycho-oncology programs addressed for this vulnerable segment of the population.

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Association between Mental Disorders and Subsequent Medical Conditions

Cited by 323 publications

References 39 publications

How mental health care should change as a consequence of the COVID-19 pandemic

How mental health care should change as a consequence of the COVID-19 pandemic

Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic companion of psychiatric disorders: common pathways and future approaches

Cancer and severe mental illness: Bi‐directional problems and potential solutions

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