Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population

Lordelo, Graciana Souza; Miranda-Vilela, Ana Luisa; Akimoto, Arthur K.; Alves, Penha Cristina Zaidan; Hiragi, C. O.; Nonino, Alexandre; Daldegan, Margarete Barbosa; Klautau-Guimarães, M. N.; Grisólia, César Koppe

doi:10.4238/2012.april.19.6

Cited by 40 publications

(36 citation statements)

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“…The Brazilian population is very mixed, primarily because of five centuries of interethnic crosses among Europeans (European colonizers, mainly represented by the Portuguese), Africans (slaves) and Amerindians (the indigenous population) (Parra et al ., 2003; Hiragi et al ., 2011; Lordelo et al ., 2012; Barbosa et al ., 2014); this miscegenation can strongly influence the distribution of certain polymorphisms (Lordelo et al ., 2012; Barbosa et al ., 2014). Moreover, Brazil's large geographic size and the fact that different population groups have moved to different parts of the country has resulted in considerable phylogeographical heterogeneity (Parra et al ., 2003).…”

Section: Discussionmentioning

confidence: 99%

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

2016

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Exercise is a double-edged sword: when practiced in moderation, it increases the expression of antioxidant enzymes, but when practiced strenuously it causes oxidative stress and cell damage. In this context, polymorphisms in the interleukin (IL)-6 gene should be investigated better because they can influence performance, at least in exercise that generates oxidative stress and leads to muscular injuries with consequent inflammation. In this work, we investigated the influence of IL-6 –174 G/C polymorphism on tissue damage and inflammation markers, lipid peroxidation, hemogram and lipid profile of runners before and after ingestion of 400 mg of pequi oil in capsules supplied daily for 14 consecutive days. The IL-6 genotypes were associated with significant differences in lipid peroxidation, with the CC mutant having lower values. There were also significant differences among these genotypes in the response to supplementation with pequi oil, exercise-induced damage and C-reactive protein (CRP) levels. The best protection against damage was observed with the heterozygous genotype. Although the CC genotype showed an increase in CRP levels after supplementation, the lack of a positive correlation between triglycerides and high-sensitivity CRP in this mutant genotype after supplementation indicated a protective effect of pequi. These findings deserve further investigation, particularly with regard to the quantification of circulating IL-6 concentrations.

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Section: Discussionmentioning

confidence: 99%

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

2016

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“…Therefore, it is important to know their frequency in our population and make comparisons with other populations, because our three-hybrid genetic mixture can influence the distribution of certain polymorphisms (Miranda-Vilela et al, 2010;Lordelo et al, 2012;Barbosa et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…As the Brazilian population is very mixed, primarily from five centuries of interethnic crosses among Europeans, Africans and Amerindians, and this miscegenation can influence the distribution of certain polymorphisms (Lordelo et al, 2012;Barbosa et al, 2014), the objective of this study was to investigate the role of MTHFR (C677T, A1298C) and CBS (T833C/844ins68, CBS G919A) polymorphisms in serum levels of folic acid, vitamin B12 and Hcy in Brazilian patients with a diagnosis of thrombosis, and to verify a possible association between these polymorphisms and the clinical variability.…”

Section: Introductionmentioning

confidence: 99%

Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes

et al. 2017

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ABSTRACT. High plasma homocysteine (Hcy) levels may be responsible for vaso-occlusive episodes and may have acquired and/or genetic causes. This cross-sectional study aimed to investigate the role of methylenetetrahydrofolate reductase (MTHFR; C677T; A1298C) and cystathionine-b-synthase (CBS; T833C/844ins68, G919A) polymorphisms in serum levels of folic acid, vitamin B12 and Hcy, and to verify a possible association between these polymorphisms and the clinical variability. Blood samples of Brazilian patients with a diagnosis of thrombosis were submitted to genotyping by PCR-based methods and serum dosages of folic acid, vitamin B12 and Hcy. Except for the CBS G919A polymorphism, all other genetic markers were in HardyWeinberg equilibrium. An increased risk for venous thrombosis was found for the MTHFR 1298CC carriers (OR = 1.688; 95%CI = 0.839-3.398, P = 0.018) and those homozygously mutant for the CBS haplotype 844ins68/T833C (OR = 2.488; 95%CI = 0.501-12.363, P = 0.031), while heterozygous for this CBS haplotype showed an increased risk for higher Hcy levels (OR = 5.900; 95%CI = 1.003-34.691, P = 0.030). Significant interactions were observed among the MTHFR C677T, MTHFR A1298C and CBS haplotype 844ins68/T833C polymorphisms in the results for Hcy levels (P = 0.000), where heterozygous had higher values. Interactions among these polymorphisms can affect serum Hcy levels, where multiple heterozygosis could be a risk factor for vasoocclusive episodes.

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“…The population of Gujarat were monogamy and marriages were done within the same community as non-random mating (Gadgil and Malhoera, 1983) and therefore the overrepresentation of null alleles among the population. In addition, under certain environmental conditions, natural selection of certain phenotypes allow for increased fitness among the populations (Barreiro, 2008;Lordelo, 2012).…”

Section: Discussionmentioning

confidence: 99%

Impact of Tobacco on Glutathione S Transferase Gene Loci of Indian Ethnics

Senthilkumar¹,

Ramasamy²

2012

Asian Pacific Journal of Cancer Prevention

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Background: Tobacco contains agents which generate various potent DNA adducts that can cause gene mutations. Production of DNA adducts may be neutralized by glutathione S transferase (GST) along with other phase I and phase II enzyme systems. The existence of null type of GST among the population increases the susceptibility to various disorders and diseases. The present study focuses on the impact of high tobacco usage and possible null type mutation in GST loci. Methods: Genotypes of GST were detected by multiplex polymerase chain reaction in unrelated 504 volunteers of high tobacco using natives of Gujarat. Allelic frequencies were calculated using Statistical Package for Social Studies-16 software. Hardy Weinberg Equilibrium (HWE) was calculated using Chi square test. Two sided Fisher's significance test was used to compare allelic frequencies of different populations. Results: The frequency of homozygous null genotype of GSTM1 and GSTT1 were 20% (95% CI 16.7-23.9) and 35.5% (95% CI 31.4-39.9) respectively. The GSTM1 and GSTT1 null allele frequency distribution in the Gujarat population was significantly deviating from HWE. GSTT1 null frequency of Gujaratians was significantly higher and different to all reported low tobacco using Indian ethnics, while GSTM1 was not differing significantly. Conclusion: Tobacco usage significantly influences the rate of mutation and frequency of GSTT1 and M1 null types among the habituates. The rate of mutation in GSTT1 loci was an undeviating response to the dose of tobacco usage among the population. This mutational impact of tobacco on GSTT1 postulates the possible gene -environment interaction and selection of null genotype among the subjects to prone them under susceptible status for various cancers and even worst to cure the population with GSTT1 dependent drugs.

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Association between methylene tetrahydrofolate reductase and glutathione S-transferase M1 gene polymorphisms and chronic myeloid leukemia in a Brazilian population

Cited by 40 publications

References 91 publications

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

Association between interleukin 6 -174 G/C promoter gene polymorphism and runners' responses to the dietary ingestion of antioxidant supplementation based on pequi (Caryocar brasiliense Camb.) oil: a before-after study

Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes

Impact of Tobacco on Glutathione S Transferase Gene Loci of Indian Ethnics

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