Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population

Cai, Min; Zhang, Yitong; Ma, Yanyun; Li, Wenshuai; Min, Pei; Qiu, Jigang; Xu, Weihong; Zhang, Mingqing; Li, Min; Li, Li; Liu, Yi; Yang, Dongqin; Zhang, Jun; Fang, Cheng

doi:10.1016/j.bulcan.2015.09.012

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…Of the 65 studies, sample sizes ranged from 175 to 3,585, and publication year ranged from 2009 to 2017. In total, there were 2 acute lymphoblastic leukemia studies (Gutierrez-Camino et al, 2014 ; Hasani et al, 2014 ), 10 breast cancer studies (Hu et al, 2009 ; Catucci et al, 2010 ; Alshatwi et al, 2012 ; Bansal et al, 2014 ; Omrani et al, 2014 ; He et al, 2015 ; Qi et al, 2015 ; Dai et al, 2016 ; Afsharzadeh et al, 2017 ), 3 bladder cancer studies (Mittal et al, 2011 ; Deng et al, 2015 ; Wang et al, 2016 ), 5 colorectal cancer studies (Min et al, 2012 ; Vinci et al, 2013 ; Hu et al, 2014 ; Dikaiakos et al, 2015 ; Ying et al, 2016 ), 2 cervical squamous cell carcinoma studies (Zhou et al, 2011 ; Srivastava et al, 2017 ), 3 esophageal cancer studies (Umar et al, 2013 ; Wei et al, 2013 ; Shen et al, 2016 ), 7 gastric cancer studies (Okubo et al, 2010 ; Ahn et al, 2013 ; Wu et al, 2013 ; Pu et al, 2014 ; Cai et al, 2015 ; Poltronieri-Oliveira et al, 2017 ; Rogoveanu et al, 2017 ), 17 hepatocellular carcinoma studies (Akkiz et al, 2011 ; Kim et al, 2012 ; Xiang et al, 2012 ; Zhou et al, 2012 , 2014 ; Shan et al, 2013 ; Zou and Zhao, 2013 ; Chu et al, 2014 ; Hao et al, 2014 ; Kou et al, 2014 ; Ma et al, 2014 ; Qi et al, 2014 ; Wang et al, 2014 ; Li D. et al, 2015 ; Li X. et al, 2015 ; Yan et al, 2015 ; Zhang et al, 2016 ), 4 lung cancer studies (Tian et al, 2009 ; Vinci et al, 2011 ; Li D. et al, 2016 ), 2 oral squamous cell cancer studies (Hou et al, …”

Section: Resultsmentioning

confidence: 99%

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

Yang

Zhou

2018

Front. Physiol.

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MicroRNAs (miRNAs) are a class of endogenous, short and non-coding RNAs that may play important roles in the pathogenesis of tumor. The associations between microRNA-499 rs3746444 polymorphism and cancer risk in different systems remain inconclusive. This article is aimed to obtain more exact estimation of these relationships through a meta-analysis based on 52,456 individuals. We retrieved relevant and eligible studies from Pubmed and Embase database up to January 10, 2018. ORs and 95% CIs were used to estimate the associations between miR-499 polymorphism and cancer susceptibility in different systems. All analyses were performed using the Stata 11.0 software. A total of 65 case-control studies were retrieved using explicit inclusion and exclusion criteria. The study included 23,762 cases and 28,694 controls. Overall cancer analysis showed the association between miR-499 polymorphism and susceptibility to cancer was significant. MicroRNA-499 rs3746444 was found to be significantly associated with increased risk of cancer of the respiratory system (CC vs. TT: OR = 1.575, 95% CI = 1.268–1.955, CC vs. TC+TT: OR = 1.527, 95% CI = 1.232–1.892), digestive system (CC vs. TT: OR = 1.153, 95% CI = 1.027–1.295; TC vs. TT: OR = 1.109, 95% CI = 1.046–1.176; CC+TC vs. TT: OR = 1.112, 95% CI = 1.018–1.216; CC vs. TC+TT: OR = 1.137, 95% CI = 1.016–1.272; C vs. T: OR = 1.112, 95% CI = 1.025–1.206), urinary system (TC vs. TT: OR = 1.307, 95% CI = 1.130–1.512; CC+TC vs. TT: OR = 1.259, 95% CI = 1.097–1.446; C vs. T: OR = 1.132, 95% CI = 1.014–1.264), and gynecological system (C vs. T: OR = 1.169, 95% CI = 1.002–1.364). In the subgroup analysis by ethnicity, the result showed that significant association with an increased cancer risk was found in Asian. Subgroup analysis based on type of tumor was also performed, miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma.

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Section: Resultsmentioning

confidence: 99%

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

Yang

Zhou

2018

Front. Physiol.

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“…These findings indicated that miRNAs may contribute to the development of human GC. Recently, several case–control studies identified that miRNA-499 rs3746444 A>G polymorphism might alter the risk of GC 11,14. Additionally, Tahara et al reported that the miRNA-499 rs3746444 G allele carrier was associated with a poorer prognosis in advanced GC performing chemotherapy 16.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, a number of case–control studies were carried out to explore the relationship of miRNA-499 rs3746444 A>G variants with risk of GC 10–15. Some previous studies reported that miRNA-499 rs3746444 A>G variants influenced the risk of GC and this polymorphism might be used as a potential biomarker for GC prediction 11,14. The miRNA-499 rs3746444 A>G polymorphism was also associated with overall survival and progression-free survival among cases of neoadjuvant chemotherapy 16.…”

Section: Introductionmentioning

confidence: 99%

<p>Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status</p>

Tang

Wang²,

Pan

et al. 2019

OTT

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Background MicroRNAs (miRNAs) miRNA-499 rs3746444 A>G polymorphism may be complicated in the susceptibility to cancer. However, the correlation of this polymorphism with adenocarcinoma of esophagogastric junction (AEG) was unknown. Patients and methods A total of 1063 AEG patients and 1677 controls were included in this study to assess the association of miR-499 rs3746444 A>G with AEG risk. SNPscan TM genotyping assay was harnessed to obtain the genotypes of miRNA-499 rs3746444 A>G polymorphism. Results We identified that SNP miR-499 rs3746444 A>G increased the susceptibility of AEG (AG vs AA: adjusted OR=1.25, 95% CI=1.05–1.49, P =0.012 and AG/GG vs AA: adjusted OR=1.30, 95% CI=1.10–1.54, P =0.002). In a stratified analysis, we found that miR-499 rs3746444 A>G polymorphism had an increased susceptibility of AEG in several subgroups (male subgroup: AG vs AA: adjusted P =0.004 and AG/GG vs AA: adjusted P =0.002; female subgroup: GG vs AG/AA: adjusted P =0.046; <64 years subgroup: AG vs AA: adjusted P =0.006 and AG/GG vs AA: adjusted P =0.003; never smoking subgroup: AG vs AA: adjusted P =0.003 and AG/GG vs AA: adjusted P =0.001; and never drinking subgroup: AG vs AA: adjusted P =0.008 and AG/GG vs AA: adjusted P =0.002). The results of power calculation indicated that miR-499 rs3746444 A>G polymorphism increased the risk of AEG in overall comparison, male, <64 years, never smoking, and never drinking subgroups. Among the AEG cases, 625 patients accompanied by positive lymph node. However, the distribution of miRNA-499 rs3746444 A>G variants was no significant difference between different lymph node status. Conclusion Our findings indicate that miR-499 rs3746444 A>G polymorphism is significantly associated with AEG susceptibility. In the future, further exploration of this genetic factor in relation to AEG susceptibility with an adequate methodological quality is needed.

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“…For example, it was reported that the overexpression of miR-181a, an oncomiR, in a gastric cancer cell line led to increased proliferation and inhibition of apoptosis via repression of tumor suppressor kruppel like factor 6 ( 25 ). Furthermore, a number of recent studies have focused on SNPs in miRNAs and have identified a number of SNPs that contribute to gastric cancer risk, including rs3746444 (in miR-499), rs2296616 (in miR-107) and rs2910164 (in miR-146a) ( 26 – 28 ). However, the specific functions of SNPs in miRNA remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70

Zhang

Min

et al. 2017

Oncol Lett

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Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR-1269a rs73239138 has a role in decreasing the risk of gastric cancer. The level of miR-1269a variant expression was significantly downregulated compared with the wild-type miR-1269a in the gastric cells (Fig. 1). Furthermore, overexpression of miR-1269a inhibited apoptosis of gastric cancer cells. Expression of the miR-1269a variant inhibited the function of miR-1269a by increasing the apoptotic rate and the expression of Bik, Bim and Bak was upregulated consistently. In addition, zinc-finger protein 70 (ZNF70) was identified to be a target gene of miR-1269a, which was downregulated by miR-1269a and upregulated by miR-1269a variant. ZNF70 was indicated to exert a role as a tumor suppressor in gastric cancer. To the best our knowledge, the present study for the first time highlights a critical role of miR-1269a variant rs73239138 in decreasing the susceptibility to gastric cancer by downregulating its expression and targeting ZNF70, which promotes apoptosis of gastric cancer cells. This SNP is indicated to serve as a potential biomarker and therapeutic target for gastric cancer.

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Association between microRNA-499 polymorphism and gastric cancer risk in Chinese population

Cited by 17 publications

References 26 publications

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

<p>Association of miRNA-499 rs3746444 A>G variants with adenocarcinoma of esophagogastric junction (AEG) risk and lymph node status</p>

Downregulated miRNA‑1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70

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