Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic stroke

Zhu, Ruixia; Zhao, Yating; Xiao, Tongling; Wang, Qianwen; Liu, Xu

doi:10.1016/j.ygeno.2019.12.020

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…This study indicates that genetic polymorphisms associated with the atherosclerotic process and stroke recurrence account for 27.27% of serum genetic biomarkers. Thus, Zhu et al [40] in a prospective investigation with 42 months follow-up aimed to investigate polymorphisms of five immunoinflammatory genes [C-X-C motif chemokine receptor 2 (CXCR2) rs1126579, Toll-like receptor 4 (TLR4) rs11536889, ADIPOR2 rs12342, matrix metalloproteinase-2 (MMP-2) rs7201, and MMP-9 rs1056628] in association with the recurrence of IS. They report that ADIPOR2 rs12342 was significantly associated with stroke recurrence (GG vs. AA: P = 0.025; GA vs. AA: P = 0.011; GG/GA vs. AA: P = 0.004), but not with the onset age [41].…”

Section: Genetic Polymorphisms As Biomarkers Of Ismentioning

confidence: 99%

Genetic plasma biomarkers associated with ischemic stroke

et al. 2023

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Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about the outcome of stroke patients. The current systematic review is focused on genetic plasma biomarkers as a new potential prognostic indicator for post-stroke recovery. The aim of the present systematic review is to assess the potential of genetic plasma biomarkers associated with stroke to predict post-stroke recovery. Methods: The search strategy used PubMed and Web of Science databases to identified 166 studies that investigated genetic plasma biomarkers in patients with stroke between 2017 and 2021. However, only 21 of them met the inclusion criteria. Results: The identified genetic biomarkers can be divided into: (i) serum/plasma circular RNA (circRNA) associated with stroke onset or recurrence (5; 23.80%), (ii) genetic polymorphisms associated with the atherosclerotic process and stroke recurrence (6; 28.57%), (iii) serum/plasma long non-coding RNA (lncRNA) levels involved in immunity/inflammatory processes (4; 19.04%), (iv) marker of DNA methylation associated with stroke onset and outcome (3; 14.28%), and (v) proteins and pathways of stroke identified by serum/ plasma proteomics/genomics analysis (3; 14.28%). Conclusions: Overall, more than 100 potential biomarkers were found and the data suggest that combinations of plasma genetic biomarkers might be used as a better predictor for stroke.

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Section: Genetic Polymorphisms As Biomarkers Of Ismentioning

confidence: 99%

Genetic plasma biomarkers associated with ischemic stroke

et al. 2023

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“…MicroRNAs (miRNAs) are endogenous non-coding RNAs that regulate mRNAs to affect their translation. 9 , 10 MiRNAs are initially transcribed as hairpin-containing primary transcripts (pri-miRNAs) by RNA polymerase II and then processed into precursor miRNAs (pre-miRNAs). 11 Previous studies have demonstrated the functional influence of pri-miRNAs on miRNAs; e.g., methyltransferase 1-mediated methylation regulated the structure of let-7 by changing the structure within the pri-miRNA.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of pri-let-7f, gene–environment and gene–gene interactions, and associations with ischemic stroke risk in Liaoning Province

et al. 2023

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Objective The incidence of stroke has been rising annually and investigations into traditional risk factors have led to increased attention on genetic factors. In this study, we focused on the pri-let-7f gene, and investigated the association between pri-let-7f gene polymorphisms and ischemic stroke (IS). Methods This case–control study included 1803 patients and 1456 healthy controls of Han ethnicity living in Liaoning Province. We carried out genotyping analysis of two loci, pri-let-7f-1 rs10739971 and pri-let-7f-2 rs17276588, and performed statistical analysis controlling for confounding factors by logistic regression. Results The A alleles and AA genotypes of both loci were significantly associated with an increased risk of IS. Variant genotypes of rs17276588 may also increase the risk of IS in females with alcohol intake. Gene–gene interaction analysis showed combined effects of mutations in both these single nucleotide polymorphisms (SNPs). Conclusions This study demonstrated an association between pri-let-7f SNPs and IS, providing potential latent biomarkers for the risk of IS. However, more detailed studies are needed to clarify these results.

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Association between microRNA binding site polymorphisms in immunoinflammatory genes and recurrence risk of ischemic stroke

Cited by 2 publications

References 38 publications

Genetic plasma biomarkers associated with ischemic stroke

Genetic plasma biomarkers associated with ischemic stroke

Genetic polymorphisms of pri-let-7f, gene–environment and gene–gene interactions, and associations with ischemic stroke risk in Liaoning Province

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