Association between microRNA single nucleotide polymorphisms and the risk of hepatocellular carcinoma

Li, Wenshuai; Ma, Yanyun; Zeng, Deqing; Zhang, Jun; Wang, Rui; Hu, Jingyi; Yang, Dongqin; Hu, He-Ping; Wang, Jiucun; Liu, Jie

doi:10.4067/s0034-98872016000400013

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…In gastric cancer, SNPs in miRNA machinery genes was strictly associated with cancer susceptibility and malignant behavior (Dicer and GEMIN4), or lymphatic metastasis (GEMIN4 and Ago1) (129). In hepatocellular carcinoma, SNPs in miRNA3152 and miRNA449b were linked with the risk of tumor development (130).…”

Section: Mirna In Tumorsmentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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microRNAs (miRNAs) are small non-coding RNA molecules, evolutionary conserved. They target more than one mRNAs, thus influencing multiple molecular pathways, but also mRNAs may bind to a variety of miRNAs, either simultaneously or in a context-dependent manner. miRNAs biogenesis, including miRNA transcription, processing by Drosha and Dicer, transportation, RISC biding, and miRNA decay, are finely controlled in space and time.miRNAs are critical regulators in various biological processes, such as differentiation, proliferation, apoptosis, and development in both health and disease. Their dysregulation is involved in tumor initiation and progression. In tumors, they can act as onco-miRNAs or oncosuppressor-miRNA participating in distinct cellular pathways, and the same miRNA can perform both activities depending on the context.In tumor progression, the angiogenic switch is fundamental. miRNAs derived from tumor cells, endothelial cells, and cells of the surrounding microenvironment regulate tumor angiogenesis, acting as pro-angiomiR or anti-angiomiR.In this review, we described miRNA biogenesis and function, and we update the non-classical aspects of them. The most recent role in the nucleus, as transcriptional gene regulators and the different mechanisms by which they could be dysregulated, in tumor initiation and progression, are treated. In particular, we describe the role of miRNAs in sprouting angiogenesis, vessel co-option, and vasculogenic mimicry. The role of miRNAs in lymphoma angiogenesis is also discussed despite the scarcity of data.The information presented in this review reveals the need to do much more to discover the complete miRNA network regulating angiogenesis, not only using high-throughput computational analysis approaches but also morphological ones.

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Section: Mirna In Tumorsmentioning

confidence: 99%

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

et al. 2020

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“…SNPs associated with iron metabolism of Human homeostatic iron regulator protein1 (HFE1), this text discusses various factors related to Inflammation, including Tumor necrosis factor A (TNFA), Interleukin 10 (IL-10), Interleukin 1beta (IL1B), Transforming growth factor beta (TGFB), cell cycle, oxidative stress (Glutathione S-transferase Mu 1 (GSTM1), Myeloperoxidase (MPO), Superoxide dismutase 2 (SOD2), iron metabolism (Human homeostatic iron regulator protein (HFE1), and DNA repair (Tumor protein (TP53), Mouse double minute 2 homolog (MDM2), Xray repair cross complementing3 (XRCC3), Methylenetetrahydrofolate reductase (MTHFR) were identified (7). Some inherited factors play a role in the pathogenesis of HCC (8). Early detection is critical for improved outcomes, and HCC monitoring, diagnosis, and therapy have progressed dramatically over the last 10 years.…”

Section: -Introductionmentioning

confidence: 99%

Hepatocellular Carcinoma Incidence and Risk Factors: Insights into the Significance of Genetic Heterogeneity

M. A. Ibrahim,

Ghazy,

Youssef

2023

ERU Research Journal

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Regarding mortality rates, hepatocellular carcinoma (HCC) ranks third among all cancers and sixth among all primary malignancies in frequency. Preexisting diseases include hepatitis C, hepatitis B viruses, and nonalcoholic cirrhosis; all these factors increase the risk of developing HCC. Regarding population, Egypt is third in Africa and fifteenth around the globe, making HCC a major issue. The greatest HCV prevalence was formerly seen in Egypt. It is critical to investigate the probable relationship between HCV and HCC. In Egypt, the government has implemented a mass screening program for the detection and treatment of HCV, and this strategy is anticipated to result in a future decline in the incidence of HCC. It is vital to investigate genetic markers that may assist in identifying high-risk groups and, hence, adjust screening technique indications. microRNAs and single nucleotide polymorphisms may influence multiple cellular signaling pathways connected to tumor growth and angiogenesis, making diagnosing, prognosis, and treating HCC easier. As a result, further research is required to understand liver carcinogenesis completely. The current research focuses on HCC, its risk factors, and the examination of gene polymorphisms in affected patients.

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“…HBV infection is an important cause of HCC, but only a fraction of infected patients develop HCC during their lifetime. This suggests that some genetic factors play a role in HCC development [2].…”

Section: Introductionmentioning

confidence: 99%

“…In their study, the G allele was significantly associated with the increased risk of HCC [G allele: OR (95% CI) = 1.234 (1.002-1.520), P = 0.048) compared with the A allele. Therefore, miR-449b rs10061133 could be used in association with other significant miRNA SNPs as a prediction tool[27]. Iorio and Croce(2012) reported that miRNAs can modulate critical cellular functions, including cell proliferation, differentiation, and apoptosis as well as deregulation of genes that play important roles in tumorigenesis and cancer progression.…”

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confidence: 99%

The Association between Micro-RNA Gene Polymorphisms and Development of Hepatocellular Carcinoma in Egyptian Patients

et al. 2021

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IntroductionThe development and progression of hepatocellular carcinoma (HCC) is a multistage process involving the deregulation of genes that are crucial to cellular processes. Multiple risk factors are correlated with HCC. MicroRNA is differentially expressed in development of different types of malignancies, including hepatic malignancy. Single nucleotide polymorphisms (SNPs) are the most common sequence variation in human genome. SNPs in miRNAs may affect transcription, processing or target recognition and result in malignant diseases. Aim: To determine the association between micro-RNA gene polymorphisms and development of HCC in Egyptian Patients.Material and methodsThis study included 200 individual who were matched in age and sex. Tumor staging was done using BCLC staging system. Quantification and genotyping of Micro-RNA were performed.ResultsAmong the 200 patients, 2 groups were described: group I included 90 HCC patients with a male majority (72.2%) and 110 controls in group II. Diabetes and hypertension were detected as risk factors. Three microRNA SNPs were assayed. There was a significant association between rs10061133 miR-499b and the risk of HCC. The genotypes GG or G allele were associated significantly to an increased risk of HCC (GG: OR (95% CI) = 2.91 (1.23-4.22), p = 0.013; G allele: OR (95% CI) = 1.79 (1.12- 2.15), p = 0.026) compared with the genotype of AA or AG or A allele.ConclusionsThere is an association between the mi-RNA SNPs and the susceptibility to HCC, aiming to explore some roles and mechanisms of SNPs within miRNAs in the occurrence and development of HCC.

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Association between microRNA single nucleotide polymorphisms and the risk of hepatocellular carcinoma

Abstract: Background (Rev Med Chile 2016; 144: 508-515)

Cited by 5 publications

References 20 publications

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

microRNAs Biogenesis, Functions and Role in Tumor Angiogenesis

Hepatocellular Carcinoma Incidence and Risk Factors: Insights into the Significance of Genetic Heterogeneity

The Association between Micro-RNA Gene Polymorphisms and Development of Hepatocellular Carcinoma in Egyptian Patients

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