Association between Minimal Change Esophagitis and Gastric Dysmotility: A Single-Center Electrogastrography and Endoscopy Study in Children

Abstract

Purpose: Minimal change esophagitis (MCE) is a reflux disease without mucosal breaks, known to be partially associated with abnormal gastric motor function. Electrogastrography (EGG) is commonly applied to assess gastric motor function in a noninvasive fashion. We aimed to determine the relationship between MCE and gastric myoelectrical activity (GME) recorded on EGG in children. Methods: We retrospectively assessed the records of 157 children without underlying disease who underwent both EGG and upper gastrointestinal endoscopy at Gachon University Gil Medical Center between January 2010 and June 2015. The children were stratified according to the appearance of the esophagus (normal vs. MCE). Between-group differences in EGG parameters and their correlation with each MCE finding were statistically analyzed. Results: Only the power ratio, one of the EGG parameters analyzed, differed significantly between the two groups (MCE, 1.68±3.37 vs. normal, 0.76±1.06; p＜0.05), whereas the other parameters, such as dominant frequency, dominant power, and the ratio of abnormal rhythm, showed no differences. Among children with MCE, significant correlations were noted between erythema and power ratio (p＜0.05), friability and postprandial dominant frequency (p＜0.05), and edema and/or accentuation of mucosal folds and pre-prandial frequency (p＜0.05). Helicobacter pylori infection correlated with postprandial arrhythmia (MCE, 33.59±15.52 vs. normal, 28.10±17.23; p＜0.05). EGG parameters did not differ between children with normal esophagus and those with biopsy-proven chronic esophagitis. Conclusion: In children with MCE, gastric dysmotility may affect the development of MCE, manifesting as EGG abnormalities. H. pylori infection may also affect GME. However, larger prospective investigations are needed to confirm these findings.

Electrogastrography Abnormalities in Pediatric Gastroduodenal Disorders

“…A total of 16 clinical disorders were investigated in the retrieved articles, constituting functional dyspepsia (FD) (25,26,31,(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), gastro-esophageal reflux disease (GERD) (28)(29)(30)32,33,39), idiopathic nausea (44,45), type 1 diabetes mellitus (T1DM) (15,24,46,47), eating disorders (including anorexia nervosa) (38), structural GI disorders (infantile hypertrophic pyloric stenosis, esophagitis, and gastritis/duodenitis) (29,48,49), muscular dystrophies (14), multisystem disorders (cystic fibrosis and Noonan syndrome) (16,50,51), infant colic (52), cow's milk protein allergy (CMPA) (32), chronic intestinal pseudo-obstruction (CIPO) (27), and malignancy (53). The diagnostic criteria for disorders and exclusion criteria of each included article are outlined in Supplemental Digital Content 6, http://links.lww.com/MPG/C315.…”