Association between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study

Abstract

Background. The aim of the present study was to investigate the association between monocyte to high-density lipoprotein cholesterol ratio (MHR) and nonalcoholic fatty liver disease (NAFLD) in Chinese population. Methods. We enrolled 14189 individuals who attended their annual health examinations in the study. We performed the anthropometric and laboratory measurements and diagnosed NAFLD by hepatic ultrasonography without evidence of other etiologies of chronic liver disease. Student’s t -test, Mann–Whitney U test, and chi-squared (χ2) test was used to compare the differences of clinical characteristics between participants with or without NAFLD. Pearson’s and Spearman’s analyses were performed to assess the correlation of MHR and NAFLD risk factors. Univariate and multivariate logistic regression analyses were conducted to explore whether MHR associated with NAFLD. Results. Thirty-five percent of the participants enrolled were diagnosed with NAFLD. Compared with healthy controls, NAFLD patients were male predominant, older, and had higher body mass index, waist circumference, and systolic and diastolic blood pressure, as well as higher levels of alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, triglyceride, total cholesterol, low-density lipoprotein cholesterol, fasting plasma glucose, glycated hemoglobin A1c, and serum uric acid, but lower levels of serum high-density lipoprotein cholesterol. Besides, MHR was significantly higher in NAFLD patients than healthy controls [5.35 (4.18–6.84) versus 4.53 (3.48–5.93), P < 0.001 ]. MHR quartiles were positively related to the prevalence of NAFLD ( P < 0.001 for trend). In multivariate logistic regression analysis, MHR was positively associated with the risk of NAFLD after adjusting age, gender, body mass index, waist circumference, diastolic blood pressure, alanine aminotransferase, triglyceride, total cholesterol, fasting plasma glucose, and serum uric acid (OR: 1.026, 95% CI: 1.002–1.052; P = 0.037 ). Conclusions. MHR is significantly and positively associated with the risk of NAFLD.

Diagnostic performance of novel inflammatory biomarkers based on ratios of laboratory indicators for nonalcoholic fatty liver disease

“…In our research, the NAFLD group had a median age of 45 years, with 72.5% of males and 27.5% of females, which was consistent with that reported by Huang et al ( 24 ). The study showed that the BMI of the NAFLD group was significantly higher than that of the healthy control group, consistent with Jia’s study ( 21 ), which suggested that overweight or obesity is a risk factor for NAFLD.…”

Association Between Monocyte to High-Density Lipoprotein Cholesterol Ratio and Risk of Non-alcoholic Fatty Liver Disease: A Cross-Sectional Study

“…A recently reported retrospective study involving 409 patients showed that there was a significant positive association between MHR and age, ALT and HOMA-IR values, and the risk of non-alcoholic hepatic steatosis ( 29 ). Huang et al investigated the association between MHR and NAFLD in a Chinese population of 14,189 participants and revealed that MHR was positively associated with the risk of NAFLD diagnosed by hepatic ultrasonography after multivariate logistic regression analysis ( 30 ). Our study draws a similar conclusion.…”

Monocyte to High-Density lipoprotein and Apolipoprotein A1 Ratios: Novel Indicators for Metabolic Syndrome in Chinese Newly Diagnosed Type 2 Diabetes

“…MHR was also considered as indicators of oxidative stress and systemic inflammatory disease. Several studies reported that MHR showed a powerful predictive value for chronic inflammatory disease like PCOS (10), peripheral artery disease (25), central retinal artery occlusion (26), Parkinson's Disease (11), nonalcoholic fatty liver disease (27), and STelevation myocardial infarction (28). Furthermore, Jiang et al found that MHR was significantly related to all-cause and cardiovascular mortality in the general population independent of established risk factors (9).…”