Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006

Zhang, Ruyi; Huang, Qin; Su, Guanhua; Wei, Mengsha; Cui, Yuan; Zhou, Huijuan; Song, Wenjing; Di, Dongsheng; Liu, Junan; Wang, Qi

doi:10.1186/s12891-023-06202-6

Cited by 9 publications

(7 citation statements)

References 43 publications

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“…Due to the diverse nutritional composition of food, individuals are simultaneously exposed to multiple vitamins in their daily life, an increasing number of researchers are advocating to explore the relationship of mixed vitamin exposures and human health ( 27 ). In general, BKMR, WQS regression, and qgcomp models are commonly employed to estimate the overall impact of mixed chemical exposure ( 28 , 29 ).…”

Section: Discussionmentioning

confidence: 99%

“…Prospective studies with large sample size are warranted to further verify the relationship of single dietary vitamin and periodontitis. Due to the diverse nutritional composition of food, individuals are simultaneously exposed to multiple vitamins in their daily life, an increasing number of researchers are advocating to explore the relationship of mixed vitamin exposures and human health (27). In (30).…”

Section: Discussionmentioning

confidence: 99%

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Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009–2014

Liang,

Lu,

Zhou

2024

Front. Nutr.

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BackgroundPeriodontitis is a prevalent inflammatory periodontal disease that has an impact on the overall quality of life. Although several studies have indicated an association between individual vitamin intake and periodontitis risk, the associations of the multivitamins with periodontitis risk remain unclear.AimThis study aimed to explore the joint effect of multivitamins (including vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and vitamin K) on periodontitis.MethodsFor this cross-sectional study, data were collected from participants aged ≥ 30 years in the National Health and Nutrition Examination Surveys 2009–2014 (n = 9,820). We employed weighted multivariate logistic regression models to evaluate the single association between individual vitamin intakes and periodontitis, and Bayesian kernel machine regression (BKMR), weighted quantile sum (WQS) regression, and quantile g-computation (qgcomp) models to assess the joint effect of nine vitamins on periodontitis.ResultsThe overall prevalence of periodontitis was approximately 35.97%. After adjustment of covariates, vitamin B6 [odds ratio (OR) = 0.82, 95% confidence interval (CI): 0.72–0.94] and vitamin E (OR = 0.79, 95%CI: 0.69–0.92) were negatively related to the likelihood of developing periodontitis, respectively. The result of three models indicated that, mixture of vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, and vitamin K had a significant negative combined effect on the risk of periodontitis. In the BKMR model, when all remaining vitamins were at their median levels, the periodontitis risk decreased with increased concentration levels of vitamin E and vitamin B2. WQS analysis indicated the highest weighted chemical was vitamin E, followed by vitamin B12 and vitamin D. In the qgcomp model, vitamin E received the highest negative weights for the periodontitis risk, followed by vitamin B2 and vitamin D, respectively.ConclusionBoth dietary vitamin B6 and vitamin E were associated with decreased odds of periodontitis. Additionally, the mixture-exposed analyses consistently showed the negative correlations between nine dietary vitamins mixtures and periodontitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009–2014

Liang,

Lu,

Zhou

2024

Front. Nutr.

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“…Given the physiological changes in older adults, such as reduced chewing and digestive ability and altered appetite, a comprehensive approach to nutrition is essential [ 13 , 32 ]. Unlike previous studies that focused on isolated key nutrients or specific groups such as water-soluble vitamins [ 33 ], our study examines broader dietary habits using the NHANES dataset. By not isolating bone from muscle, our research reflects the interconnected nature of the musculoskeletal system and provides a more holistic view of the role of diet in maintaining musculoskeletal health.…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Nutrients on Musculoskeletal Health in Gerontology: Understanding the Combined Impact of Macronutrients and Micronutrients

Liu,

Qian,

Shi

et al. 2024

Nutrients

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With the global aging population, addressing prevalent age-related conditions such as osteoporosis and sarcopenia is crucial. Traditional nutritional strategies focusing on single nutrients like calcium, vitamin D, or protein have limitations, prompting a nuanced exploration of the relationship between aging, nutrition, and musculoskeletal health. This cross-sectional study examines the complex interplay between dietary intake of macronutrients, common micronutrients, and water, as well as their association with musculoskeletal health in adults aged 50 to 80 years, using U.S. National Health and Nutrition Examination Survey data (NHANES). Employing multiple linear regression, restricted cubic splines, weighted quantile sum (WQS), and quantile-based g-computation (QGC) regression models, our initial analysis using the WQS model revealed that a one-quartile increase in mixed macronutrient intake was associated with a significant 0.009 unit increase in bone mineral density (BMD) and a 0.670 unit increase in grip strength, while a similar increase in mixed micronutrient intake showed a 0.007 unit increase in BMD and a 0.442 unit increase in grip strength. Our findings highlight the importance of a balanced dietary approach in promoting musculoskeletal health in the elderly, offering holistic strategies for overall well-being.

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“…While numerous studies have investigated the correlation between vitamin levels and the onset and progression of eczema, existing research has predominantly focused on evaluating the impact of individual vitamins, neglecting to consider the potential effects of concurrent exposure to multiple vitamins. In fact, people are commonly exposed to combinations of vitamins, which may exhibit synergistic or antagonistic interactions ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Associations of single and multiple vitamin exposure with childhood eczema: data from the national health and nutrition examination survey

Wang,

Wang

et al. 2024

Front. Pediatr.

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AimThe association between vitamins and eczema has garnered attention, yet few studies have evaluated the effects of co-exposure to multiple vitamins on this condition. This study aims to assess the association of vitamin mixtures with eczema in children.MethodsThis cross-sectional study analyzed data from 2,244 children aged 6–17 years from the National Health and Nutrition Examination Surveys. Eczema served as the primary outcome. Six serum vitamins, namely, vitamins A, B6, B12, C, D, and E, were the main variables. Weighted multivariate logistic regression was adopted to analyze the association between each serum vitamin and eczema. Odds ratios (OR) with a 95% confidence interval (CI) were calculated. Bayesian kernel machine regression (BKMR) analysis and the quantile g-computation (qgcomp) model were used to evaluate the association of co-exposure to multiple vitamins with eczema.ResultsIn total, 10.83% of children (n = 243) developed eczema. After adjusting for confounding factors, we observed that compared with the reference group (vitamin B12 with second quartile), the OR for eczema was 0.604 (95% CI: 0.373–0.978, P = 0.041) for the first quartile of vitamin B12. Both BKMR analysis and the qgcomp model consistently showed that co-exposure to the six vitamins was positively correlated with the risk of eczema, with vitamin B6 contributing most to the overall effect. In BKMR analyses, we observed an interaction between vitamins B6 and B12 concerning eczema risk.ConclusionCo-exposure to vitamins A, C, B6, B12, D, and E was found to be associated with an increased risk of eczema in children, with vitamin B6 as the greatest positive contributor driving the overall effect.

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Association between multiple vitamins and bone mineral density: a cross-sectional and population-based study in the NHANES from 2005 to 2006

Cited by 9 publications

References 43 publications

Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009–2014

Associations between single and multiple dietary vitamins and the risk of periodontitis: results from NHANES 2009–2014

Synergistic Effects of Nutrients on Musculoskeletal Health in Gerontology: Understanding the Combined Impact of Macronutrients and Micronutrients

Associations of single and multiple vitamin exposure with childhood eczema: data from the national health and nutrition examination survey

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