Association Between Muscle Strength and Modeling Estimates of Muscle Tissue Heterogeneity in Young and Old Adults

Harris‐Love, Michael O.; Gonzales, Tomas I.; Wei, Qi; Ismail, Catheeja; Zabal, Johannah; Woletz, Paula; DiPietro, Loretta; Blackman, Marc R.

doi:10.1002/jum.14864

Cited by 11 publications

(16 citation statements)

References 43 publications

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“…More direct measurements of muscle oxidative capacity, such as tissue biopsy or imaging (47), could be used to elucidate whether this is preserved in otherwise overweight and obese participants with higher VO 2 max ffm values. Indeed, ectopic fat infiltration of skeletal muscle may be more related to impaired muscle oxidative capacity and reduced force production than overall adiposity (48,49). CRF estimated values were generally higher in the summer compared to the spring and winter.…”

Section: Discussionmentioning

confidence: 99%

Descriptive Epidemiology of Cardiorespiratory Fitness in UK Adults: The Fenland Study

Gonzales

Westgate

Hollidge

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Cardiorespiratory fitness (CRF) is rarely measured in population studies. Most studies of CRF do not examine differences by population subgroups or seasonal trends. We examined how estimated CRF levels vary by anthropometric, sociodemographic, and behavioral characteristics in a population-based cohort of UK adults (the Fenland Study). Methods: We used a validated submaximal exercise test to obtain CRF estimates (CRF estimated ) in 5976 women and 5316 men, residing in the East of England. CRF estimated was defined as estimated maximal oxygen consumption per kilogram total body mass ( VO 2 max tbm ) and fat-free mass ( VO 2 max ffm ). Descriptive statistics were computed across anthropometric and sociodemographic characteristics, and across the year. Progressive multivariable analyses were performed to examine associations with physical activity energy expenditure (PAEE) and body mass index (BMI). Results: Mean ± SD VO 2 max tbm was lower in women (35.2 ± 7.5 mL•min −1 •kg −1 ) than men (41.7 ± 7.3 mL•min −1 •kg −1 ) but VO 2 max ffm was similar (women: 59.2 ± 11.6 mL•min −1 •kg −1 ; men: 62.0 ± 10.3 mL•min −1 •kg −1 ). CRF estimated was inversely associated with age but not after adjustment for PAEE. People in more physically demanding jobs were fitter compared with those in sedentary jobs, but this association was attenuated in women and reversed in men after adjustment for total PAEE. Physical activity energy expenditure and BMI were positively associated with CRF estimated at all levels of adjustment when expressed relative to fat-free mass. CRF estimated was 4% higher in summer than in winter among women, but did not differ by season among men. Conclusions: CRF estimated was inversely associated with age but less steeply than anticipated, suggesting older generations are comparatively fitter than younger generations. Physical activity energy expenditure and BMI were stronger determinants of the variance in CRF estimated than other characteristic including age. This emphasizes the importance of modifiable physical activity behaviors in public health interventions.

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Section: Discussionmentioning

confidence: 99%

Descriptive Epidemiology of Cardiorespiratory Fitness in UK Adults: The Fenland Study

Gonzales

Westgate

Hollidge

et al. 2022

Medicine &Amp; Science in Sports &Amp; Exercise

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“…The field of view was adjusted for each participant to optimally capture the region of interest of the RF on the dominant side. Standardized procedures were followed for the identification of the scanning site, as previously described (45,47).…”

Section: Diagnostic Ultrasound Estimatesmentioning

confidence: 99%

Rate of Force Development Is Related to Maximal Force and Sit-to-Stand Performance in Men With Stages 3b and 4 Chronic Kidney Disease

Gollie¹,

Harris‐Love²,

Patel³

et al. 2021

Front. Rehabilit. Sci.

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Introduction: The primary aims of the present study were to assess the relationships of early (0–50 ms) and late (100–200 ms) knee extensor rate of force development (RFD) with maximal voluntary force (MVF) and sit-to-stand (STS) performance in participants with chronic kidney disease (CKD) not requiring dialysis.Methods: Thirteen men with CKD (eGFR = 35.17 ±.5 ml/min per 1.73 m2, age = 70.56 ±.4 years) and 12 non-CKD men (REF) (eGFR = 80.31 ± 4.8 ml/min per 1.73 m2, age = 70.22 ±.9 years) performed maximal voluntary isometric contractions to determine MVF and RFD of the knee extensors. RFD was measured at time intervals 0–50 ms (RFD0−50) and 100–200 ms (RFD100−200). STS was measured as the time to complete five repetitions. Measures of rectus femoris grayscale (RF GSL) and muscle thickness (RF MT) were obtained via ultrasonography in the CKD group only. Standardized mean differences (SMD) were used to examine differences between groups. Bivariate relationships were assessed by Pearson's product moment correlation.Results: Knee extensor MVF adjusted for body weight (CKD=17.14 ±.1 N·kg0.67, REF=21.55 ±.3 N·kg0.67, SMD = 0.79) and STS time (CKD = 15.93 ±.4 s, REF = 12.23 ±.7 s, SMD = 1.03) were lower in the CKD group than the REF group. Absolute RFD100−200 was significantly directly related to adjusted MVF in CKD (r = 0.56, p = 0.049) and REF (r = 0.70, p = 0.012), respectively. STS time was significantly inversely related to absolute (r = −0.75, p = 0.008) and relative RFD0−50 (r = −0.65, p = 0.030) in CKD but not REF (r = 0.08, p = 0.797; r = 0.004, p = 0.991). Significant inverse relationships between RF GSL adjusted for adipose tissue thickness and absolute RFD100−200 (r =−0.59, p = 0.042) in CKD were observed.Conclusion: The results of the current study highlight the declines in strength and physical function that occur in older men with CKD stages 3b and 4 not requiring dialysis. Moreover, early RFD was associated with STS time in CKD while late RFD was associated MVF in both CKD and REF.Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT03160326 and NCT02277236.

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“…More direct measurements of muscle oxidative capacity, such as tissue biopsy or imaging 43 , could be used to elucidate whether this is preserved in otherwise overweight and obese participants with higher VO 2 max ffm values. Indeed, ectopic fat infiltration of skeletal muscle may be more related to impaired muscle oxidative capacity and reduced force production than overall adiposity 44,45 .…”

Section: Discussionmentioning

confidence: 99%

Descriptive epidemiology of cardiorespiratory fitness in UK adults: The Fenland Study

Gonzales

Westgate

Hollidge

et al. 2022

Preprint

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BackgroundCardiorespiratory fitness is rarely measured in population studies. Most studies of fitness do not examine differences by population subgroups or seasonal trends.MethodsWe used a validated submaximal exercise test to measure fitness in 5976 women and 5316 men, residing in England. We expressed fitness as maximal oxygen consumption per kilogram total body mass (VO2maxtbm) and fat free mass (VO2maxffm). Descriptive statistics were computed across anthropometric and sociodemographic characteristics, as well as across the year. Progressive multivariable analyses were performed to examine mediation by physical activity energy expenditure (PAEE) and BMI.ResultsMean±SD VO2maxtbm was lower in women (35.4±7.6 ml·min-1·kg-1) than men (42.1±7.4 ml·min-1·kg-1) but VO2maxffm was similar (women: 59.7±11.8 ml·min-1·kg-1; men: 62.5±10.4 ml·min-1·kg-1). Fitness was inversely associated with age but not after adjustment for PAEE. People in more physically demanding jobs were fitter compared to those in sedentary jobs but this association was attenuated in women and reversed in men following adjustment for total PAEE. PAEE and BMI and were positively associated with fitness at all levels of adjustment when fitness was expressed relative to fat-free mass. Fitness during summer was 4% higher than the winter among women, but did not differ by season among men.ConclusionsFitness was inversely associated with age but less steeply than anticipated, suggesting older generations are comparatively fitter than younger generations. PAEE and BMI were stronger determinants of the variance in fitness than any other characteristic including age. This emphasizes the importance of modifiable physical activity behaviours in public health interventions.KEY MESSAGESFitness was inversely associated with age but less steeply than anticipated, suggesting older generations are comparatively fitter than younger generationsRelationships between cardiorespiratory fitness and sociodemographic characteristics were primarily mediated by physical activity.A one standard deviation difference in physical activity had the same impact on cardiorespiratory fitness as being 25 years younger

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Association Between Muscle Strength and Modeling Estimates of Muscle Tissue Heterogeneity in Young and Old Adults

Cited by 11 publications

References 43 publications

Descriptive Epidemiology of Cardiorespiratory Fitness in UK Adults: The Fenland Study

Descriptive Epidemiology of Cardiorespiratory Fitness in UK Adults: The Fenland Study

Rate of Force Development Is Related to Maximal Force and Sit-to-Stand Performance in Men With Stages 3b and 4 Chronic Kidney Disease

Descriptive epidemiology of cardiorespiratory fitness in UK adults: The Fenland Study

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