Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

Liu, Xiaohong; Ye, Hehua; Zhang, Qi; Cai, Xiushan; Yu, Wenjing; Yu, Siyi; Wang, Tianyu; Lu, Wuyi; Li, Xiang; Zhao, Peiquan

doi:10.1371/journal.pone.0165281

Cited by 13 publications

(13 citation statements)

References 21 publications

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“…Much similar to other studies [13, 21, 22], slightly more than half of our patients were hyperopes, while emmetropia accounted for a third of the patients. The proportion of myopic eyes in our population is rather similar to that reported by Yong et al [13] but lower than the 30% reported by Liu et al [10]. Earlier studies reported lower numbers of myopes in angle closure patients, between 1.86 and 5.5%, perhaps attributed by the fact that these studies are done in the western countries.…”

Section: Discussionsupporting

confidence: 85%

“…The AL in our myopic eyes ranged between 21.46 and 24.20 mm, suggesting a lenticular rather than axial myopia. This range of AL falls in the ranges reported by other studies in Singapore (AL range 21.33–27.48 mm in highly myopic eyes, range: −5 to −11.88 D) and China (AL range 21.58–26.20 mm in myopic eyes, range: −0.50 to −6.75 D), suggesting lenticular myopia as part of the causes of their myopias [10, 13]. Unfortunately, both studies did not grade their cataract status in their analysis.…”

Section: Discussionsupporting

confidence: 75%

“…The occurrence of myopia is on the rise due to more prevalent modern lifestyles such as more time spent on near work, less time outdoors, and higher educational level [9]. Myopia with longer AL had a lower prevalence of iris trabecular meshwork contact [10]. However, there are multiple reports on myopia in angle closure subjects [11-13].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Loh¹,

Kamaruddin²,

Bastion³

et al. 2020

Ophthalmic Res

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Introduction: The aim of the study was to evaluate the refractive status and ocular biometric parameters in subjects with angle closure in Malaysia. Methods: This cross-sectional study was conducted on 171 primary angle closure patients (268 eyes). Visual acuity, refraction, and ocular biometry (central anterior chamber depth [ACD], axial length [AL], and lens thickness) were recorded. Vitreous cavity length (VL) and relative lens position (RLP) were calculated. Results: A total of 92 Primary Angle Closure Suspect (PACS), 30 Primary Angle Closure (PAC), and 146 Primary Angle Closure Glaucoma (PACG) eyes were included. Chinese ethnicity formed the majority (n = 197, 73.5%), followed by Malay (n = 57, 21.3%) and Indian (n = 14, 5.2%). There was a significant female preponderance with a female to male ratio of 1.85. Mean age was 65.7 ± 7.7 years. Mean spherical equivalent was +0.33 ± 1.29 D. Approximately half (n = 137, 51%) of the eyes were hyperopic (spherical power ≥+0.5), with PACG having the highest percentage of hyperopia (n = 69, 50.4%). Myopia and emmetropia were present in 48 (17.9) and 83 (31%) eyes, respectively. Although AL and VL in myopia patients were significantly longer than emmetropic and hyperopic eyes (p < 0.001), the ACD was not significantly different (p = 0.427). While the RLP is smaller in myopic eyes, lens thickness was increased in hyperopic eyes. PACG was significantly higher in elderly patients compared to PACS and PAC (p = 0.005). A total of 37 (13.8%) eyes were blind (vision worse than 3/60) and 19 of them (51.3%) were female patients. Conclusion: A decrease in RLP is predictive of angle closure disease in myopic eyes, whereas increased lens thickness contributes to angle closure disease in hyperopic eyes.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 75%

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Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Loh¹,

Kamaruddin²,

Bastion³

et al. 2020

Ophthalmic Res

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“…As for other anterior segment biometric parameters, Dong J et al reported deep ACD, lower CRP, and greater CA in the high myopia group than in the normal group [ 16 ]. Yet, another large, cross-sectional, population-based study of Chinese individuals reported shallow ACD in persons with myopia, even those with long ALs [ 15 ]. Furthermore, few studies have investigated the characteristics of corneal astigmatism in high myopic eyes using adult samples.…”

Section: Introductionmentioning

confidence: 99%

Associations between anterior segment biometry and high axial myopia in 3438 cataractous eyes in the Chinese population

et al. 2022

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Background To investigate the associations between anterior segment biometry and high axial myopia in cataractous eyes in the Chinese population. Methods Data on 3438 eyes from 3438 subjects were analyzed in this cross-sectional study. Anterior segment biometry, axial length measurements, and intraocular pressure evaluation were implemented using an Oculus Pentacam HR, a Zeiss IOLMaster 500, and a Nidek TonoRef II, respectively. A multivariate-adjusted logistic model and a multivariate-adjusted linear model were used for statistical analysis. Results The mean age of the subjects was 62.2 ± 10.6 years, and 56.4% were female. There were 2665 subjects with high axial myopia (axial length, ≥26.50 mm) and 773 without (axial length, < 26.50 mm). The characteristics independently associated with high axial myopia included lower total corneal refractive power, a more negative Q value, greater total corneal astigmatism, greater white-to-white corneal diameter, greater anterior chamber depth, and higher intraocular pressure (all P < 0.05). In addition, greater axial length correlated with a thicker temporal cornea and a thinner nasal cornea (both P < 0.001). Conclusions For cataractous eyes, high axial myopia was associated with corneal flattening, increased total corneal astigmatism, anterior segment enlargement, and intraocular pressure elevation. The findings may inform the choice of intraocular lenses and the calculation of their power, help improve the surgical practice of refractive cataract procedures, and provide useful information on the centration and stability of intraocular lenses.

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“…Myopic eyes usually have long ALs and are predisposed to deep ACDs and open angles, thereby protecting against PACD because of the divergent ocular biometry of these conditions. 10 , 12 – 16 However, although Chinese populations have a higher prevalence of myopia compared with Western populations, many epidemiologic studies also show a high prevalence of AC. 17 , 18 Moreover, Jin et al 19 reported that the increasing prevalence of myopia has minimal impact on the prevalence of occludable angles, with myopia prevalence increasing from 10% to 60% and narrow-angle prevalence decreasing from 11.1% to 9.6%.…”

mentioning

confidence: 99%

Anterior Segment Characteristics and Risk Factors for Primary Angle Closure Disease With Long Axial Lengths: The Handan Eye Study

Zhang

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To investigate the anterior segment characteristics of primary angle closure disease (PACD) with long axial length (AL) compared with that of those with short and medium AL and explore the risk factors associated with AC with different AL levels. Methods This observational cross-sectional study enrolled subjects aged 35 years or older who completed the follow-up examinations of the Handan Eye Study and dichotomized them into normal and PACD groups. Ocular data of the right eye were analyzed. AL was categorized into short (<22.0 mm), medium (22.0–24.0 mm), or long (>24.0 mm) subgroups. Demographic and anterior segment parameters of PACD subjects were compared between the three AL subgroups. Logistic regression analysis was performed to identify the risk factors for PACD in the three subgroups. Results Data from 715 PACD and 1446 normal subjects were analyzed. Only 6.6% of the PACD eyes had long AL, with lower spherical equivalent, larger anterior chamber depth ( P < 0.001), and smaller lens thickness ( P < 0.001) than those with short and medium AL. No significant differences were found for angle opening distance and iris parameters on comparing the values of eyes with long AL with that of those with short and medium AL. Significant risk factors for the development of PACD with long AL were peripheral iris thickness, anterior chamber width, and lens vault. Conclusions PACD with long AL was uncommon. A thicker peripheral iris, larger lens vault, and smaller ACW contributed to angle closure in these patients.

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Association between Myopia, Biometry and Occludable Angle: The Jiangning Eye Study

Cited by 13 publications

References 21 publications

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Evaluation of Refractive Status and Ocular Biometric Parameters in Primary Angle Closure Disease

Associations between anterior segment biometry and high axial myopia in 3438 cataractous eyes in the Chinese population

Anterior Segment Characteristics and Risk Factors for Primary Angle Closure Disease With Long Axial Lengths: The Handan Eye Study

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