Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

Zhu, Jinhong; Fu, Wen; Jia, Wei Hua; Xia, Hongmei; Liu, Guo-chang; He, Jing

doi:10.1016/j.omtn.2018.08.002

Cited by 44 publications

(45 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, we have also observed that once oral cancer is established the C allele enhanced the risk of having high stage malignant disease with nodal involvement. Several other cases have reported the link of XPD A/C polymorphism with the development of different cancer in different population indicates its universal role in carcinogenesis (Du et al, 2016;Smolarz et al, 2019;Avci et al, 2018;Zhu et al, 2018).…”

Section: Discussionmentioning

confidence: 94%

Risk Modulation of Oral Pre Cancer and Cancer with Polymorphisms in XPD and XPG Genes in North Indian Population

Nigam

Yadav

Bhatt

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background:Environmental carcinogens cause DNA damages which if not repaired properly, may increase the risk of cancer. The Xerodermapigmentosum group D (XPD) and group G (XPG) genes are essential genes for DNA repair and alteration in DNA repair causes cancer. The present study aimed to evaluate the relationship between XPD and XPG polymorphisms and risk of oral pre cancer and cancer. Methods:Present study genotyped 302 samples of oral diseases and 300 controls for XPD (A/C) and XPG (G/C) polymorphisms with PCR-RFLP method. Results:Our result showed that compared to AA genotype frequency of AC and CC genotype for XPD(A/C) polymorphism were significantly lower among cases than in control and are associated with decreased risk of oral diseases (OR= 0.621 and 0.603 respectively). In contrast with reference to GG genotype the frequency of CC genotype of XPG (G/C) was significantly higher in case than in control population (p value=0.004) and found to increase the risk of oral diseases (OR= 2.077). Particularly C allele for XPD A/C polymorphism was found to be associated with decreased risk of Lichen planus and increased risk of ( OR = 0.470 and 1.541 respectively) oral cancer. While C allele of XPG G/C polymorphism significantly increased the risk of Oral Submucous Fibrosis and Leukoplakia (OR= 1.879 and 1.837 respectively) but not of Lichen planus and oral cancer. In combined genotype analysis from the aforesaid polymorphisms presence of C allele for XPD (A/C) polymorphisms were found to decrease the risk of oral diseases. However, the same C allele was observed to increase the chance of having high stage disease (OR= 5.71) with nodal involvement (OR= 6.78) once the cancer been initiated. Conclusion:This work shows association of XPD (A/C), XPG (G/C) polymorphisms with the development of pre oral cancer as well as oral cancer and its clinical courses.

show abstract

Section: Discussionmentioning

confidence: 94%

Risk Modulation of Oral Pre Cancer and Cancer with Polymorphisms in XPD and XPG Genes in North Indian Population

Nigam

Yadav

Bhatt

et al. 2019

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…GTEx Portal database (https://www.gtexportal. org/home/) was used to evaluate the correlation between genotypes of the selected polymorphisms and LIN28B mRNA expression levels [24].…”

Section: Genotype and Gene Expression Correlation Analysismentioning

confidence: 99%

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

et al. 2020

Self Cite

View full text Add to dashboard Cite

Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma. To detect the association between LIN28B gene polymorphisms and hepatoblastoma risk in Chinese children, we conducted a five-center case-control study of 275 hepatoblastoma patients and 1018 cancer-free controls. Four potentially functional polymorphisms were genotyped using the Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. We found that the rs314276 C>A polymorphism (AA vs. CC: adjusted OR=2.05, 95% CI=1.36-3.10, P=0.0006; AA vs. CA/CC: adjusted OR=2.11, 95% CI=1.43-3.12, P=0.0002) and rs9404590 T>G (GG vs. TT: adjusted OR=1.89, 95% CI=1.20-3.00, P=0.007; GG vs. TT/TG: adjusted OR=1.87, 95% CI=1.20-2.92, P=0.006) were associated with increased hepatoblastoma risk. Combination analysis of risk genotypes showed that patients with four risk genotypes had a higher chance of developing hepatoblastoma than carriers of 1 to 3 risk genotypes. Stratification analysis showed the significant association between the rs314276 AA genotype and hepatoblastoma risk in both age and sex groups, as well as clinical stages III+IV cases. The rs9404590 GG genotype was associated with hepatoblastoma risk in participants' ≥17 months, in females, and for those with clinical stages III+IV disease. Furthermore, four risk genotypes confer higher hepatoblastoma susceptibility in both age and sex groups, as well as groups with clinical stages III+IV disease. Genotype-based gene expression analysis confirmed that the rs9404590 T>G polymorphism was significantly associated with altered LIN28B gene expression. We further validated our findings using false-positive probability analysis. This finding suggested that LIN28B gene polymorphisms may be associated with an increased predisposition to hepatoblastoma.

show abstract

“…A total of 145 histopathologically confirmed cases of WT from Guangdong province (Southern China) were included in our study, [15][16][17][18][19][20][21] along with 531 unrelated, age-, gender-, and race-matched cancer-free controls. [22][23][24] Both imaging and pathological examination were used to diagnose the disease.…”

Section: Study Subjectsmentioning

confidence: 99%

Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility

Gao

Jia

Zhu

et al. 2019

Clinical Laboratory Analysis

Self Cite

View full text Add to dashboard Cite

BackgroundWilms tumor (WT) is the most common pediatric renal malignancy. Previous genome‐wide association studies have identified that the LINC00673 rs11655237 C>T polymorphism is associated with the risk of several types of cancer. However, few studies have investigated the association between LINC00673 rs11655237 C>T and WT susceptibility.MethodWe genotyped LINC00673 rs11655237 C>T in 145 patients with WT and 531 cancer‐free controls recruited from southern Chinese children. The strength of association was estimated by odds ratios (ORs) and 95% confidence intervals (CIs).ResultsOur study indicated that there was no significant association between LINC00673 rs11655237 C>T polymorphism and WT risk under all the tested genetic models (CT vs CC: adjusted OR = 0.94, 95% CI = 0.63‐1.40; TT vs CC: adjusted OR = 0.60, 95% CI = 0.22‐1.59; TT/CT vs CC: adjusted OR = 0.89, 95% CI = 0.61‐1.31; and TT vs CC/CT: adjusted OR = 0.61, 95% CI = 0.23‐1.61). Further stratified analysis detected no significant association, either.ConclusionIn conclusion, we failed to find any association between the LINC00673 rs11655237 C>T polymorphism and WT risk. This finding needs to be verified in larger studies and other populations.

show abstract

Association between NER Pathway Gene Polymorphisms and Wilms Tumor Risk

Cited by 44 publications

References 41 publications

Risk Modulation of Oral Pre Cancer and Cancer with Polymorphisms in XPD and XPG Genes in North Indian Population

Risk Modulation of Oral Pre Cancer and Cancer with Polymorphisms in XPD and XPG Genes in North Indian Population

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility

Contact Info

Product

Resources

About