Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort

Ying, Hongan; Gao, Lijie; Liao, Nansheng; Xu, Xiping; Yu, Wei; Hong, Weiwen

doi:10.1186/s12885-022-10265-4

Cited by 19 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, patients with HCC with low Knic levels had worse overall survival (Extended Data Fig. 9f), which is consistent with the finding of a previous study showing that higher dietary NA intake was related to lower mortality in patients with cancer and that NA supplements improved cancer survival rates 29 . These results indicate that Knic expression regulates the oncoprotein PPFIA1 and, therefore, is a predictor of prognosis in patients with HCC.…”

Section: Ppfia1 Facilitates Hcc Metastasissupporting

confidence: 91%

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Zhang,

Jiang,

et al. 2024

Preprint

View full text Add to dashboard Cite

Vitamin B3 is the major precursor of NAD+ and NADP+, however it was unknown whether this vitamin supplementation could modify histone epigenetically. Here, we report nicotinic acid (NA), a component of vitamin B3, suppresses liver cancer metastasis specifically, via stimulating histone lysine nicotinylation (Knic). Importantly, nicotinyl-CoA, that metabolically generated by NA via ACSS2, stimulates histone Knic in vivo and in vitro. Histone Knic regulates chromatin accessibility and inhibits binding of transcription factor HOXB9 to the promoter of oncogene PPFIA1, resulting in inhibition of hepatocyte carcinoma progression. Notably, we found that NA specific induces histone Knic and suppresses hepatocyte carcinoma progression, whereas nicotinamide, an amide form of nicotinic acid, does not stimulate nicotinylation, instead promotes tumour growth and metastasis. These findings suggest that vitamin B3 supplementation may contribute to cancer progression depending on its composition. Collectively, we demonstrated that histone lysine nicotinylation is a histone mark controlling gene expression and NA supresses liver cancer progression by inducing histone lysine nicotinylation.

show abstract

Section: Ppfia1 Facilitates Hcc Metastasissupporting

confidence: 91%

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Zhang,

Jiang,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…This correlation persisted across various subgroups, including sex, age, and BMI. Kaplan–Meier survival analyses revealed higher survival rates in groups with high niacin intake compared to those with low intake, although this did not extend to all-cause mortality 24 . In the context of lung health, niacin has demonstrated benefits in reducing inflammation.…”

Section: Discussionmentioning

confidence: 83%

“…Furthermore, niacin supplementation has been shown to positively impact cancer mortality. A cohort study with 3504 participants demonstrated a negative association between niacin intake and cancer mortality, with significant P values in all models 24 . This correlation persisted across various subgroups, including sex, age, and BMI.…”

Section: Discussionmentioning

confidence: 94%

Association of dietary niacin intake with the prevalence and incidence of chronic obstructive pulmonary disease

Li,

Ren,

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Evidence regarding the association between dietary niacin intake and chronic obstructive pulmonary disease (COPD) is limited. Our study investigates the relationship between dietary niacin intake and the prevalance and incidence of COPD in the adult population of the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2003 to 2018. Data on niacin intake were extracted through dietary intake interviews. COPD diagnoses were based on lung function, medical history, and medication usage. We analyzed the association between niacin consumption and COPD using multiple logistic regression and restricted cubic spline models. The study included 7055 adult participants, divided into COPD (n = 243; 3.44%) and non-COPD (n = 6812; 96.56%) groups. Those with COPD had lower average niacin intake (21.39 ± 0.62 mg/day) compared to the non-COPD group (25.29 ± 0.23 mg/day, p < 0.001). In the adjusted multivariable model, the odds ratios (OR) and 95% confidence intervals (CI) for COPD in the highest versus lowest quartile of dietary niacin intake were 0.55 (0.33 to 0.89, P for trend = 0.009). Subgroup analysis, after adjustment for various variables, revealed no significant interaction effects. Dietary niacin intake was inversely associated with COPD prevalence in US adults. Participants with the highest dietary niacin intake demonstrated the lowest odds of COPD. The potential of dietary niacin supplementation as a strategy to mitigate COPD warrants further investigation.

show abstract

“…Interestingly, Ying and coworkers [ 55 ], using NHANES data from 1999 to 2014, investigated the association between dietary niacin intake and mortality in cancer patients. They found that niacin intake was negatively associated with mortality outcomes in patients with cancer, and the association persisted in subgroup analyses based on sex, age, and body mass index.…”

Section: Discussionmentioning

confidence: 99%

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

Tosti,

Pepe,

Gnagnarella

et al. 2023

Nutrients

View full text Add to dashboard Cite

Background: Nicotinamide is the active form of vitamin B3 (niacin) obtained through endogenous synthesis, mainly through tryptophan metabolism and dietary supplements, fish, meats, grains, and dairy products. It participates in cellular energy metabolism and modulates multiple cellular survival and death pathways. Nicotinamide has been widely studied as a safe chemopreventive agent that reduces actinic keratosis (AKs) and non-melanoma skin cancers (NMSC). Methods: We used the Medline, EMBASE, PubMed, and Cochrane databases to search the concepts “nicotinamide”, “chemoprevention”, and “skin cancer” up to August 2023. Three independent authors screened titles and abstracts for intervention and study design before searching full texts for eligibility criteria. The primary outcome was the impact of oral nicotinamide on the incidence of NMSC in high-risk patients. We also conducted a systematic search to identify relevant epidemiological studies published evaluating dietary niacin intake and the risk of NMSC. Results: Two hundred and twenty-five studies were reviewed, and four met the inclusion criteria. There was no association between NAM consumption and risk for squamous cell carcinoma (SCC) (rate ratio (RR) 0.81, 95% CI 0.48–1.37; I2 = 0%), basal cell carcinoma (BCC) (RR 0.88, 95% CI 0.50–1.55; I2 = 63%), and NMSC (RR 0.82, 95% CI 0.61–1.12; I2 = 63%). Adverse events were rare and acceptable, allowing optimal compliance of patients to the treatment. We found only one article evaluating the association between niacin dietary intake and NMSC risk, supporting a potential beneficial role of niacin intake concerning SCC but not BCC or melanoma. Conclusions: The present meta-analysis shows, by pooling immunocompetent and immunosuppressed patients, that there is insufficient evidence that oral nicotinamide therapy significantly reduces the number of keratinocyte cancers.

show abstract

Association between niacin and mortality among patients with cancer in the NHANES retrospective cohort

Cited by 19 publications

References 29 publications

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Nicotinic acid suppresses liver cancer metastasis via histone lysine nicotinylation

Association of dietary niacin intake with the prevalence and incidence of chronic obstructive pulmonary disease

The Role of Nicotinamide as Chemo-Preventive Agent in NMSCs: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About