Association between nocturnal oxygen desaturation and ischaemic stroke outcomes

Wojtasz, Izabela; Tomski, Andrzej; Kaźmierski, Radosław

doi:10.5603/pjnns.a2022.0033

Cited by 3 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HRV analysis has found wide recognition in medical research as a non-invasive method of assessing HR regulation and an indicator assessing the risk of serious cardiovascular events. It is reasonable to postulate that the sympathetic activation and HRV alterations associated with PLMS may play a role in the occurrence of desaturation episodes during sleep, potentially worsening stroke outcomes [28].…”

Section: Introductionmentioning

confidence: 99%

Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability

Malkiewicz,

Grzywinska,

Malinowski

et al. 2024

Neurol Neurochir Pol.

View full text Add to dashboard Cite

Introduction. The phenomenon known as periodic limb movements in sleep (PLMS) has been linked to a change in autonomic nervous system (ANS) activity and its effect on circulatory regulation. Autonomic dysfunction or dysregulation in patients with PLMS has been described in some domains; however, any relationship between heart rate variability (HRV) and PLMS has not been clearly established. HRV analysis is a recognised, non-invasive research method that describes the influence of the ANS on heart rate (HR). The aim of our study was to further investigate the dysregulation of autonomic HR control in patients with PLMS. Material and methods.We undertook a retrospective analysis of the polysomnographic (PSG), demographic and medical data of five patients with a total number of 1,348 PLMS. We analysed HR, HRV HF, systolic blood pressure (SBP), and diastolic blood pressure (DBP) for 10 heartbeats before the series of PLMS and 10 consecutive heartbeats as beat-to-beat measurements. The presented method of using successive, short, 10 RR interval segments refers to the time-frequency measurement, which is very clear and useful for presenting changes in the calculated parameters over time and thereby illustrating their dynamics. This method allowed us to assess dynamic changes in HRV HF during successive PLMS series. Statistical analysis was performed using IBM SPSS Statistics (v. 28.0.0.0). The Kruskal-Wallis test was performed to find statistically significant changes from baseline. Results. No statistically significant changes in HR, SBP, or DBP were found in our group, although an increase in the value of the HRV HF was noted, suggesting an increase in intracardiac parasympathetic activity during the subsequent series of PLMS. Conclusions.Our study indicates an increase in parasympathetic activity during the appearance of successive PLMS, which, with the simultaneous lack of changes in HR, may suggest an increase in sympathetic activity, and therefore the appearance of so-called 'autonomic co-activation' resulting in the possibility of life-threatening cardiac events. Clinical implications. Our findings add to the literature information regarding HRV in PLMS, and highlight the need for further studies to elucidate the effects of these conditions on the ANS, and on cardiovascular health.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability

Malkiewicz,

Grzywinska,

Malinowski

et al. 2024

Neurol Neurochir Pol.

View full text Add to dashboard Cite

show abstract

The Effects of Intranasal Implantation of Mesenchymal Stem Cells on Nitric Monoxide Levels in the Hippocampus, Control of Cognitive Functions, and Motor Activity in a Model of Cerebral Ischemia in Rats

et al. 2023

View full text Add to dashboard Cite

Hypoxia occurs in situations of disbalancebetween metabolic needs and the supply of oxygen to organs and tissues of the body. In this regard, tissue hypoxia and ischemia are essential components of the pathogenesis of many diseases. One of the promising areas of research into the mechanisms of ischemia is attempting to weaken the negative effect of hypoxia and ischemia in the brain by using a variety of techniques that activate neuroprotective mechanisms. Here, we aimed to assess the dynamics of restoration of motor activity control in an experimental model of ischemic stroke in rats (cerebral ischemia -CI) after intranasal perineural implantation of mesenchymal stem cells into the receptive eld of the olfactory nerve.It was found that the perineural administration of MSCs to rats in the acute period of cerebral ischemia was accompanied by clear signs of recovery of cognitive and motor functions within 1 and 3 days after the operation. On the seventh day after ischemia modeling, rats with the introduction of MSCs had no distinctive features in the control of motor activity compared to the period before the operation in the same rats. In the hippocampus of rats after modeling ischemia, a signi cant decrease in the content of NO by about 50% relative to the initial level is observed after one day. In the hippocampus of rats in which ischemia was modelled with simultaneous intranasal administration of MSC, a signi cant decrease in NO content by 39% relative to the initial level was also observed after one day. The content of NO increases slightly, but the difference in the level of NO relative to ischemic rats was not signi cant. The copper content in the hippocampus in the rats of these two groups did not change. There was a tendency to increase the e ciency of the antioxidant system 1 day after ischemia in both studied groups, and this effect was more pronounced with intranasal administration of MSC.

show abstract

Heart Rate Variability and Interoception in Periodic Limb Movements in Sleep: Interference with Psychiatric Disorders?

Małkiewicz,

Malinowski,

Grzywińska

et al. 2024

JCM

View full text Add to dashboard Cite

Periodic limb movements in sleep (PLMS) are a prevalent disorder characterized by rhythmic, involuntary movements of the lower limbs, such as dorsiflexion of the ankle and extension of the big toe, occurring in periodic intervals during sleep. These movements are often linked to disrupted autonomic nervous system (ANS) activity and altered interoception. Interoception involves perceiving internal bodily states, like heartbeat, breathing, hunger, and temperature, and plays a crucial role in maintaining homeostasis and the mind–body connection. This review explores the complex relationships between PLMS, heart rate variability (HRV), ANS dysregulation, and their impact on psychiatric disorders. By synthesizing the existing literature, it provides insights into how ANS dysregulation and altered interoceptive processes, alongside PLMS, contribute to psychiatric conditions. The review highlights the potential for integrated diagnostic and therapeutic approaches and presents a cause-and-effect model illustrating the mutual influence of psychiatric disorders, ANS dysregulation, PLMS, and interoception.

show abstract

Association between nocturnal oxygen desaturation and ischaemic stroke outcomes

Cited by 3 publications

References 32 publications

Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability

Effect of series of periodic limb movements in sleep on blood pressure, heart rate and high frequency heart rate variability

The Effects of Intranasal Implantation of Mesenchymal Stem Cells on Nitric Monoxide Levels in the Hippocampus, Control of Cognitive Functions, and Motor Activity in a Model of Cerebral Ischemia in Rats

Heart Rate Variability and Interoception in Periodic Limb Movements in Sleep: Interference with Psychiatric Disorders?

Contact Info

Product

Resources

About