Association between Norovirus and Rotavirus Infection and Histo-Blood Group Antigen Types in Vietnamese Children

Abstract

; all were HBGA secretors or partial secretors. This is the first epidemiological study demonstrating in a population that HBGA phenotype is a key susceptibility factor for both norovirus and rotavirus infections in children.

Rotavirus infection and histo-blood group antigens in the children hospitalized with diarrhoea in China

“…In a study on Africans, the Lewis-negative population and non-secretors accounted for ~32% and ~20% in 208 individuals [4], much higher than in China. P [6] accounted for almost 50% of infections in Africans [4], whereas none were detected in this study. All these indicated the genetic difference of various populations may contribute to the prevalence of different RV genotypes.…”

“…For the Lewis antigen, Le y+ was the most common, accounting for about 94% (397/424), followed by Le b+ (79%, 337/424), Le a+ (38%, 159/424), and Le x+ (22%, 95/424) ( Table 2). Furthermore, 62% (263/424) of them were secretors, with Le a-b+ or Le x-y+ ; 35% (150/424) were partial secretors, with Le a+b+ or Le x+y+ ;and only 3% (11/424) were non-secretors, with Le a+b-or Le x+y- (Table 2).Whereas, in the study of Vietnamese all the M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 5 individuals were Lewis-positive and ~12% were non-secretors [6]. In Americans, ~ 6% were Lewis-negative [10].…”

“…Previous studies have shown that P [4] and P [8] VP8* bind to Le b and H1-type HBGAs, whereas P [6] binds only to H1 type [2,3].In addition, several epidemiological studies have shown certain interactions between HBGA status and RV infections in different regions and populations [4][5][6].However, there is no previously reported epidemiological study of RVs and HBGAs in China.…”

Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion

“…The relevant human clinical strain Wa did not recognize HBGAs, which is consistent with the observed lack of influence of genetically controlled expression of different HBGAs on pediatric rotavirus gastroenteritis 46,47 . Interestingly, two recent studies suggested that non-secretor individuals (null homozygote fucosyltransferase, FUT2) are not susceptible to infection with the most common rotaviruses 48,49 . However, this finding appears inconsistent with the well-established fact that by 2-3 years of age, essentially all children excrete rotavirus at least once and/or seroconvert to rotavirus regardless of their secretor status 50,51 .…”

Role of histo-blood group antigens in primate enteric calicivirus infections

“…It was proposed that human NoVs bind with carbohydrate moieties of the ABH and Lewis antigens when these are secreted into biological fluids and that such binding is associated with productive infection and illness [27][28][29] . In fact, inhibition of HBGA binding was suggested as an antiviral strategy for treatment of NoV infection [30] .…”